{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":79,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":79,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12"},"query_hash":"4f5cee314480","filters":{"venue":"Protein Engineering Design and Selection"}},"results":[{"id":"W3093745921","doi":"10.1093/protein/gzaa024","title":"Protein Engineering, Design and Selection","year":2020,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"","keywords":"Reputation; Constructive; Selection (genetic algorithm); Publishing; Foundation (evidence); Library science; Computer science; Engineering; Data science; Operations research; Management; Sociology; Political science; Process (computing); Artificial intelligence; Social science","retraction":null,"screen_n_in":null,"score":{"opus":0.01466189599409519,"gpt":0.2172602292567869,"spread":0.2025983332626917,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000353662,0.0002083219,0.0001513836,0.00008515024,0.00008510012,0.0000784953,0.00008414687,0.0002096679,0.000007710998],"category_scores_gemma":[0.0003564151,0.0002044168,0.0000324127,0.0002080497,0.00003393909,0.00001369161,0.00005276991,0.0002148005,0.000005507314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002010828,"about_ca_system_score_gemma":0.00005864854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007789725,"about_ca_topic_score_gemma":6.325158e-7,"domain_scores_codex":[0.9988934,0.00005066237,0.0002154295,0.0003143268,0.0001912437,0.0003349131],"domain_scores_gemma":[0.999553,0.00001513135,0.00004161455,0.00005724815,0.00008065252,0.0002524053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009726889,0.00001815371,0.00002101662,0.0001883655,0.00003704095,8.418378e-7,0.00006512063,0.007857948,0.9871003,0.00003778214,0.0002234272,0.00435276],"study_design_scores_gemma":[0.0003977305,0.001048668,0.0001546354,0.00003005486,0.000009478005,0.00001659708,0.000006829616,0.447459,0.5443831,0.00001520144,0.006259649,0.0002190583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09663114,0.0003956227,0.9016044,0.0002408413,0.00002699032,0.00100672,0.000001225661,0.00008314659,0.000009898502],"genre_scores_gemma":[0.874379,0.0001902252,0.1246076,0.00006923283,0.0003126791,0.0001934511,0.0000113735,0.00004054849,0.0001959618],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.7777478,"threshold_uncertainty_score":0.8335874,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2119531077","doi":"10.1093/protein/13.11.801","title":"Analysis of binding of the family 2a carbohydrate-binding module from Cellulomonas fimi xylanase 10A to cellulose: specificity and identification of functionally important amino acid residues","year":2000,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":145,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Amgen (Canada); University of British Columbia","funders":"","keywords":"Tryptophan; Cellulose; Chemistry; Carbohydrate-binding module; Tyrosine; Binding site; Residue (chemistry); Cellulase; Stereochemistry; Biochemistry; Alanine; Cellulosome; Amino acid","retraction":null,"screen_n_in":null,"score":{"opus":0.009714009641262405,"gpt":0.1787366486363708,"spread":0.1690226389951084,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962505,0.000146259,0.0002384261,0.0003514014,0.00005375958,0.00001934155,0.00007364708,0.00009718603,0.00003707257],"category_scores_gemma":[0.00002140443,0.0001321042,0.00006517959,0.0009317596,0.00002840365,0.00009974745,0.00001411944,0.0001134548,0.00000114483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004880641,"about_ca_system_score_gemma":0.00001152514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566119,"about_ca_topic_score_gemma":0.000006638181,"domain_scores_codex":[0.9989681,0.00003813919,0.0004393217,0.0002342729,0.000191306,0.0001289075],"domain_scores_gemma":[0.9996185,0.00002443031,0.0001060714,0.0001378776,0.00006224009,0.00005093179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004419156,0.00001889867,0.001345425,0.0001181113,0.0001572292,1.993986e-7,0.0001667534,0.07595513,0.9213666,0.00001121708,0.00001622593,0.0008000712],"study_design_scores_gemma":[0.0001053338,0.00004010189,0.02071753,0.00003389941,0.0001293887,5.233633e-7,0.0000272335,0.2043662,0.7744052,0.0000108781,0.00005867864,0.0001049917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960791,0.000461228,0.03816912,0.00001782884,0.00009603012,0.0003662558,0.00002703146,0.00005920095,0.00001228926],"genre_scores_gemma":[0.997941,0.000132676,0.001717819,0.000001854648,0.0000346857,0.0000162931,0.00001915818,0.00001640581,0.0001201141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1469613,"threshold_uncertainty_score":0.5387054,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125029324","doi":"10.1093/protein/gzg095","title":"Fine mapping and structural analysis of immunodominant IgE allergenic epitopes in chicken egg ovalbumin","year":2003,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Epitope; Ovalbumin; Immunoglobulin E; Chemistry; Allergen; Amino acid; Egg white; Epitope mapping; Antibody; Biochemistry; Allergy; Biology; Immunology; Antigen","retraction":null,"screen_n_in":null,"score":{"opus":0.0140920993889931,"gpt":0.2396724443054515,"spread":0.2255803449164584,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003559485,0.0001074993,0.0002683923,0.0005654395,0.00003718771,0.00000984196,0.00002438253,0.00006751789,0.00002921965],"category_scores_gemma":[0.0001437816,0.00009562309,0.00004461058,0.0008740608,0.00002192075,0.00004475799,0.000009984025,0.0001683852,3.104612e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002726099,"about_ca_system_score_gemma":0.0000254645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008128472,"about_ca_topic_score_gemma":0.00003230238,"domain_scores_codex":[0.9992754,0.00005470238,0.000197942,0.0001748553,0.0001147333,0.0001824035],"domain_scores_gemma":[0.999782,0.00003567051,0.00003164127,0.000061373,0.00003790494,0.00005144717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001844086,0.00003410766,0.003458548,0.0002192336,0.0006553143,0.000007844495,0.0003735745,0.01061042,0.9740472,0.0005489189,0.000002786353,0.00985758],"study_design_scores_gemma":[0.001816039,0.0006885474,0.3341329,0.0002296745,0.00007535685,0.00004961388,0.00006722214,0.4639966,0.1981129,0.0001265555,0.0004077047,0.0002968756],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972433,0.002619529,0.02451547,0.00004261919,0.00001586102,0.0003355436,4.861114e-7,0.00001945804,0.00001801755],"genre_scores_gemma":[0.9934886,0.0001674543,0.006199508,0.000002233887,0.00001241923,0.00002776576,0.000003545028,0.00001051484,0.00008799564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7759343,"threshold_uncertainty_score":0.3899397,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1989202961","doi":"10.1093/protein/gzt057","title":"Semi-rational approach for converting a GH1  -glycosidase into a  -transglycosidase","year":2013,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Canadian Glycomics Network; European Synchrotron Radiation Facility","keywords":"Thermus thermophilus; Glycoside hydrolase; Hydrolysis; Mutagenesis; Hydrolase; Chemistry; Enzyme; Mutant; Biochemistry; Site-directed mutagenesis; Directed evolution; Stereochemistry; Active site; Saturated mutagenesis; Gene; Escherichia coli","retraction":null,"screen_n_in":null,"score":{"opus":0.007205339398512438,"gpt":0.1953933184713576,"spread":0.1881879790728452,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363523,0.0001146931,0.00007461252,0.00004929926,0.00009630203,0.0000440367,0.0000339922,0.00009213408,0.000009100484],"category_scores_gemma":[0.0000750137,0.0001188058,0.00002897385,0.00008153333,0.00001195161,0.00001858748,0.000008763249,0.00005907756,0.000001891537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001366803,"about_ca_system_score_gemma":0.00002103514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009757988,"about_ca_topic_score_gemma":3.520955e-7,"domain_scores_codex":[0.9993943,0.00002439101,0.0001354257,0.0002490741,0.00005809088,0.0001387455],"domain_scores_gemma":[0.9997432,0.000006179735,0.00003694323,0.00005509745,0.0001034167,0.0000552071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004082784,0.00002786416,0.00003168429,0.00007827025,0.00001770077,3.408688e-8,0.00004084237,0.004260623,0.9938421,0.0001167962,0.0001166523,0.00142656],"study_design_scores_gemma":[0.0003495348,0.0001532223,0.0001457411,0.000009323215,0.000007241595,0.00001116564,0.000009214576,0.2136407,0.7842064,0.00005377506,0.001268975,0.0001447127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2089323,0.0001173048,0.7899895,0.00009047654,0.00002948837,0.0007902574,8.552532e-7,0.00004295014,0.000006875503],"genre_scores_gemma":[0.9343908,0.0000135107,0.06406403,0.00005386726,0.0002124684,0.0009085939,0.0001050548,0.00002261286,0.0002289921],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7259255,"threshold_uncertainty_score":0.484476,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2130398470","doi":"10.1093/protein/gzn071","title":"Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points","year":2008,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; University of Guelph; National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Single-domain antibody; Chemistry; Isoelectric point; Cysteine; Complementarity determining region; Disulfide bond; Biochemistry; Antibody; Biophysics; Peptide sequence; Molecular biology; Computational biology; Biology; Enzyme; Genetics; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01245712616468984,"gpt":0.2311650032306972,"spread":0.2187078770660073,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366107,0.0001940202,0.0002518374,0.0004207756,0.0001401871,0.00002354908,0.000038316,0.0001080473,0.0000096718],"category_scores_gemma":[0.0002655823,0.0001801068,0.00002592981,0.0008629794,0.00004105979,0.0001043249,0.00001879804,0.0002998758,0.000005691134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845781,"about_ca_system_score_gemma":0.00008798757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750678,"about_ca_topic_score_gemma":0.00001383657,"domain_scores_codex":[0.9986949,0.00006688786,0.0002405501,0.0003372422,0.0002770218,0.0003834009],"domain_scores_gemma":[0.9995016,0.00006804141,0.00003417484,0.0000663071,0.000120742,0.0002090906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001322076,0.00007556217,0.001791404,0.0001040026,0.00002977142,0.00001989763,0.0001243161,0.0001149083,0.9934652,0.00005225505,0.0002726947,0.002627918],"study_design_scores_gemma":[0.001923352,0.001300026,0.04705357,0.0002038289,0.00002917664,0.0004149798,0.00002164953,0.1289684,0.8187779,0.0001343952,0.0007608748,0.0004117591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9136559,0.001888312,0.08257364,0.0005557816,0.0000207203,0.001187386,0.000003555891,0.00009524211,0.00001943964],"genre_scores_gemma":[0.9914615,0.0001792712,0.007012243,0.00003429242,0.00005870915,0.0001558268,0.00002156557,0.00002643325,0.001050174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1746873,"threshold_uncertainty_score":0.7344542,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2147946492","doi":"10.1093/protein/gzi003","title":"Engineering of a thioglycoligase: randomized mutagenesis of the acid-base residue leads to the identification of improved catalysts","year":2005,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":69,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund","keywords":"Chemistry; Azide; Mutagenesis; Biochemistry; Mutant; Site-directed mutagenesis; Catalysis; Saturated mutagenesis; Thio-; Combinatorial chemistry; Glycoside; Residue (chemistry); Stereochemistry; Organic chemistry; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.005704961379378202,"gpt":0.1845008770157734,"spread":0.1787959156363952,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000760542,0.000146046,0.0003050088,0.00006755046,0.00004560546,0.00001337717,0.0001635587,0.00009580533,0.00001223444],"category_scores_gemma":[0.0007718295,0.0001054101,0.0001230919,0.0003276455,0.00003443541,0.00005416125,0.00002725191,0.0001142683,4.664919e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004376513,"about_ca_system_score_gemma":0.00003438353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004968776,"about_ca_topic_score_gemma":0.000004641032,"domain_scores_codex":[0.9989855,0.00003871149,0.0005044993,0.0001757674,0.0001593873,0.0001361318],"domain_scores_gemma":[0.9992332,0.0001720029,0.0002142511,0.0002441462,0.0000988287,0.00003757701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007997649,0.00002465957,0.000007467602,0.0003913167,0.00005628294,9.758974e-8,0.0002594482,0.05387447,0.9439843,0.00002591603,0.000006002796,0.0005702439],"study_design_scores_gemma":[0.001739503,0.000007618338,0.00002278006,0.0001066029,0.0000721125,0.000004439499,0.00001257751,0.1171497,0.8807707,0.000003714532,0.00002167631,0.00008857681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396026,0.0003140305,0.05930735,0.0001434455,0.00002615026,0.0005409464,0.000008097654,0.00004209866,0.00001535195],"genre_scores_gemma":[0.9972605,0.00001522039,0.002228695,0.000002623995,0.0000632656,0.0002378983,0.000002169031,0.00001999319,0.0001696283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06327525,"threshold_uncertainty_score":0.4298498,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2197946614","doi":"10.1093/protein/gzv043","title":"A switchable yeast display/secretion system","year":2015,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Chinese Academy of Agricultural Sciences; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","keywords":"Phage display; Yeast; Secretion; Reagent; Computational biology; Cloning (programming); Directed evolution; Chemistry; Peptide library; Biochemistry; Combinatorial chemistry; Computer science; Biology; Peptide sequence; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.02858249430632098,"gpt":0.2485158658668351,"spread":0.2199333715605142,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807663,0.00009643911,0.0001309701,0.00009681471,0.00004821159,0.00002521177,0.00002264639,0.00006024434,0.000005848176],"category_scores_gemma":[0.00004979739,0.00008020161,0.00002387865,0.0001685621,0.0000113012,0.00006307006,0.00001280029,0.0001423589,0.00002669018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008759045,"about_ca_system_score_gemma":0.00005085581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008513467,"about_ca_topic_score_gemma":7.588662e-7,"domain_scores_codex":[0.9993364,0.00002539297,0.0001056772,0.0001460672,0.0002020939,0.0001843531],"domain_scores_gemma":[0.999653,0.00001171429,0.00001753342,0.00004476685,0.00008333322,0.0001895989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001156224,0.00008580781,0.001269056,0.001077044,0.00009585395,0.0000442993,0.0002765168,0.004214903,0.9793124,0.007128437,0.0005811859,0.004758276],"study_design_scores_gemma":[0.000980907,0.0009752323,0.00171969,0.0003341138,0.00003015703,0.0005177485,0.00005633809,0.9480717,0.04025506,0.00005415374,0.006817041,0.0001878671],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5057855,0.000593204,0.4916036,0.0002919879,0.00009139078,0.0008981949,0.000001346782,0.0002559496,0.0004787849],"genre_scores_gemma":[0.9879157,0.00001225493,0.01023811,0.000009847964,0.0001987613,0.00009028656,0.000006025445,0.00001651889,0.001512521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9438568,"threshold_uncertainty_score":0.3270527,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2113485885","doi":"10.1093/protein/gzq022","title":"Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm","year":2010,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; McMaster University; National Science Foundation; National Institutes of Health; National Cancer Institute; Michael J. Fox Foundation for Parkinson's Research","keywords":"Cytoplasm; Intracellular; Extracellular; Biophysics; Cytosol; Peptide; Biochemistry; Chemistry; Cell biology; Biology; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.01134900612328599,"gpt":0.2490779290731724,"spread":0.2377289229498864,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543927,0.00009839651,0.0001704148,0.000111573,0.00002206949,0.000008469124,0.00003675444,0.00009446089,0.0000245901],"category_scores_gemma":[0.00003865985,0.00008509907,0.00002689815,0.0001394805,0.00002404465,0.00005501553,0.00001931387,0.0003254933,0.000003661503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001292675,"about_ca_system_score_gemma":0.00003025286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003963883,"about_ca_topic_score_gemma":0.000004204992,"domain_scores_codex":[0.9993469,0.00001548846,0.0001543493,0.0001516998,0.0001385364,0.0001930653],"domain_scores_gemma":[0.9997674,0.0000329039,0.00002721727,0.00005529246,0.00003611144,0.00008108335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002137846,0.00009117052,0.003171843,0.0002543136,0.000002711488,0.000007160698,0.0000654781,0.00007155293,0.9934497,0.00002535312,0.00002211967,0.002624774],"study_design_scores_gemma":[0.0004777522,0.0001774672,0.003637255,0.0000963334,0.000004464345,0.00003292784,0.00000305792,0.04575358,0.9494042,0.00003720019,0.0002943133,0.00008141992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935037,0.00004688134,0.005921543,0.00003472109,0.0000433291,0.0003639895,5.274125e-7,0.00002429578,0.00006099735],"genre_scores_gemma":[0.9815738,0.00001374238,0.0178467,0.000004301924,0.00007948363,0.00004474129,0.000001960874,0.00001346921,0.0004218435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04568202,"threshold_uncertainty_score":0.3470239,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2151598579","doi":"10.1093/protein/gzq003","title":"Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display","year":2010,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Eye Institute; National Institute of General Medical Sciences; Kungliga Tekniska Högskolan; Wellcome Trust","keywords":"Antibody; Biology; Syk; Phage display; SH2 domain; LYN; Epitope; Computational biology; Proto-oncogene tyrosine-protein kinase Src; Virology; Molecular biology; Tyrosine kinase; Cell biology; Genetics; Phosphorylation; Signal transduction","retraction":null,"screen_n_in":null,"score":{"opus":0.02082791032007614,"gpt":0.2648394664938969,"spread":0.2440115561738208,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244475,0.0001466325,0.0002142638,0.0001415696,0.0001249044,0.00002880365,0.00005029251,0.00007630831,0.0000334413],"category_scores_gemma":[0.00003984591,0.0001249039,0.00003962747,0.0001934457,0.00003331036,0.00005515925,0.0000237772,0.0002898158,0.00000544942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001693044,"about_ca_system_score_gemma":0.00002078696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007230194,"about_ca_topic_score_gemma":0.000007348712,"domain_scores_codex":[0.9991043,0.00002261982,0.0001989201,0.0002158959,0.0002101055,0.0002482033],"domain_scores_gemma":[0.9996414,0.00003206728,0.00003228512,0.00007868846,0.00007011803,0.0001454306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001050518,0.00005479425,0.0004624426,0.0001407734,0.00003064475,0.000005711654,0.0001229536,0.0003319768,0.9958161,0.0006061878,0.0005169417,0.001806443],"study_design_scores_gemma":[0.0005569506,0.0007621642,0.002712319,0.0001086305,0.00001711002,0.0000641046,0.000009292798,0.03313523,0.9522061,0.00002616057,0.0101904,0.0002115634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316801,0.0002636261,0.06706923,0.0002126511,0.00004833389,0.000591603,0.000006417618,0.00005927596,0.00006877485],"genre_scores_gemma":[0.9640409,0.0000372043,0.03418428,0.00002074251,0.0002411892,0.00005634972,0.00001559168,0.00002355191,0.001380232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04361,"threshold_uncertainty_score":0.5093432,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154607931","doi":"10.1093/protein/gzh035","title":"Improvement of cyclodextrin glucanotransferase as an antistaling enzyme by error-prone PCR","year":2004,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Cyclodextrin; Enzyme; Chemistry; Hydrolysis; Mutant; Biochemistry; Starch; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.006658311504675361,"gpt":0.2104217543953918,"spread":0.2037634428907164,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001375486,0.0001158069,0.00008751282,0.0000458743,0.00004772654,0.00001832768,0.00003984818,0.00008749915,0.000005582333],"category_scores_gemma":[0.00002193718,0.0001268744,0.00002069297,0.00009369122,0.00001436094,0.00001496507,0.000008449374,0.00006525162,6.8858e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002025921,"about_ca_system_score_gemma":0.00003435671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000421635,"about_ca_topic_score_gemma":0.000002248519,"domain_scores_codex":[0.9993754,0.00001693435,0.0001557888,0.0002403588,0.00008062652,0.0001308761],"domain_scores_gemma":[0.9997738,0.000001367203,0.0000392454,0.00007800478,0.00005155989,0.00005604301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006841849,0.00006276627,0.00001421719,0.00004504724,0.00001703062,3.834628e-7,0.00003683039,0.0082019,0.9900976,0.0001148669,0.000007090451,0.001333877],"study_design_scores_gemma":[0.0005046793,0.0006718274,0.00006828142,0.0000191951,0.000008455974,0.00001466627,0.000009080848,0.002116727,0.9958569,0.00004177346,0.0005462781,0.0001421003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5691628,0.0001310509,0.430378,0.0000344258,0.00002899174,0.0002363961,0.00000210749,0.00002291284,0.000003355493],"genre_scores_gemma":[0.9942858,0.00006626033,0.005286112,0.000022379,0.0000848871,0.00005395211,0.00006583532,0.00002138055,0.0001134521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4251229,"threshold_uncertainty_score":0.5173786,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2157131730","doi":"10.1093/protein/gzh090","title":"Combinatorial exploration of the catalytic site of a drug-resistant dihydrofolate reductase: creating alternative functional configurations","year":2004,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Active site; Dihydrofolate reductase; Mutagenesis; Point mutation; Context (archaeology); Binding site; Mutation; Enzyme; Biology; Stereochemistry; Chemistry; Biochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.009148863680971689,"gpt":0.2308892016294086,"spread":0.2217403379484369,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204696,0.0000874755,0.00008343417,0.0000406633,0.00005814466,0.000008961716,0.00003481016,0.0000436857,0.000001184374],"category_scores_gemma":[0.00007752618,0.00007826194,0.00003439065,0.0001223729,0.00002314078,0.00001104803,0.0000157557,0.00006108529,1.883357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001826066,"about_ca_system_score_gemma":0.00004312198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005158759,"about_ca_topic_score_gemma":0.000004635303,"domain_scores_codex":[0.9995059,0.00002051733,0.0001655459,0.0001283733,0.00009473757,0.00008486265],"domain_scores_gemma":[0.9997472,0.000009712076,0.00006850857,0.00007299845,0.00007851017,0.00002303592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003829007,0.00001568068,0.000009208326,0.00002848349,0.00002125085,6.975478e-8,0.0001503418,0.2686721,0.729955,0.001062074,0.000002778629,0.00004466991],"study_design_scores_gemma":[0.0004770804,0.0001288896,0.0003813235,0.00005444179,0.00001805449,0.000004151726,0.00002100863,0.01498222,0.9834345,0.0003738407,0.00004450544,0.00007999593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5076287,0.0001597347,0.4918009,0.00002508021,0.00009590631,0.0002635224,0.000003754455,0.00000837857,0.00001407885],"genre_scores_gemma":[0.9977013,0.00001439563,0.002092939,0.000001783443,0.00008931498,0.0000454594,0.00001625941,0.00001127757,0.00002719978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4900727,"threshold_uncertainty_score":0.3191429,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2123737549","doi":"10.1093/protein/14.12.983","title":"Kinetic characterization of ribonuclease S mutants containing photoisomerizable phenylazophenylalanine residues","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":50,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Photoisomerization; Chemistry; Ribonuclease; Enzyme; Stereochemistry; RNase P; Kinetics; Azobenzene; Kinetic energy; Crystallography; Reaction rate constant; Substrate (aquarium); Isomerization; Biochemistry; Molecule; Biology; Organic chemistry; Catalysis; RNA; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.009260626519482654,"gpt":0.1926649569647412,"spread":0.1834043304452586,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010687,0.0001326044,0.0001755064,0.00006299587,0.00006336137,0.00003473303,0.00007123567,0.00006887411,0.0001292685],"category_scores_gemma":[0.00006853054,0.0001350148,0.00001832459,0.0001943321,0.00003180793,0.0001724654,0.00001676734,0.00007775537,0.000005034991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000323207,"about_ca_system_score_gemma":0.00002496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003674983,"about_ca_topic_score_gemma":3.774411e-7,"domain_scores_codex":[0.9992135,0.00002535209,0.0002160018,0.0002144171,0.000122047,0.0002086496],"domain_scores_gemma":[0.9996944,0.00001848797,0.00009098128,0.00007666311,0.00005315748,0.00006630701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460892,0.00002596075,0.0001654036,0.00006737456,0.000004792205,0.000003281079,0.0001045373,0.0006162318,0.998543,0.00003004054,0.000002047714,0.0002912282],"study_design_scores_gemma":[0.000326296,0.0001314502,0.001465212,0.0001099075,0.000009115402,0.00003053653,0.0000104708,0.05254633,0.9451366,0.00002464489,0.0000713941,0.0001380238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8558652,0.00004939041,0.1435727,0.000009458307,0.00003819861,0.0003249021,0.00000291123,0.0001091632,0.00002810198],"genre_scores_gemma":[0.9934728,0.00003572661,0.00622033,0.000008430794,0.00006458173,0.00006815795,0.000007658511,0.0000201201,0.0001021883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1376076,"threshold_uncertainty_score":0.5505744,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3170970221","doi":"10.1093/protein/gzab013","title":"Evolution of β-lactamases and enzyme promiscuity","year":2021,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Phylogenetics; Enzyme; Computational biology; Evolutionary biology; Promiscuity; Molecular evolution; Genetics; Gene; Biochemistry; Ecology","retraction":null,"screen_n_in":null,"score":{"opus":0.01576549911733675,"gpt":0.2473301918225651,"spread":0.2315646927052283,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775432,0.0001980603,0.0004355479,0.00006317138,0.00003052003,0.00002224856,0.00004542638,0.0002564775,0.000002701492],"category_scores_gemma":[0.0001289147,0.0001855138,0.00006727469,0.0001113843,0.00002809713,0.000004054602,0.00003498132,0.0001070847,2.632949e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003163033,"about_ca_system_score_gemma":0.0001131926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004986899,"about_ca_topic_score_gemma":7.765414e-7,"domain_scores_codex":[0.999204,0.00008598786,0.0002262092,0.0002944931,0.00006165535,0.0001276967],"domain_scores_gemma":[0.9996848,0.00001497842,0.0001151521,0.00009766639,0.00004852881,0.00003888637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007871534,0.0001417737,0.00007472428,0.04569127,0.0006268052,0.000006165363,0.00002958982,0.0002936488,0.5573975,0.0008791235,0.0002642396,0.3945164],"study_design_scores_gemma":[0.0006428515,0.001024715,0.0001936791,0.01827334,0.0007818991,0.0003807893,0.00001367524,0.002641719,0.08743188,0.00004551053,0.8870636,0.001506307],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00131514,0.8725765,0.1254758,0.000001173607,0.00003537994,0.0005740847,0.000003565348,0.0000138658,0.00000455222],"genre_scores_gemma":[0.007581296,0.9835454,0.008473498,6.195928e-7,0.0001207367,0.00005988832,0.00003329664,0.00003445186,0.0001507706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8867994,"threshold_uncertainty_score":0.7565034,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2148862578","doi":"10.1093/protein/gzi008","title":"Peptide inhibitors of the essential cell division protein FtsA","year":2005,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":46,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"","keywords":"FtsZ; Biopanning; Escherichia coli; Peptide; Biology; Biochemistry; Cell division; Bacteria; Antimicrobial peptides; Antimicrobial; Bacterial cell structure; Peptide library; Cell; Peptide sequence; Microbiology; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.003220226073516198,"gpt":0.1693704624990458,"spread":0.1661502364255296,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025475,0.00008580741,0.00006402605,0.00002407043,0.00008787739,0.00002134719,0.00006013182,0.00004466853,0.0001410064],"category_scores_gemma":[0.00001330731,0.00006746273,0.00003484866,0.0001462153,0.00002521697,0.0001591628,0.00004781554,0.0001209083,0.00001821653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005487079,"about_ca_system_score_gemma":0.000004652172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001040916,"about_ca_topic_score_gemma":0.00001176393,"domain_scores_codex":[0.9995062,0.00002705107,0.0001276449,0.000133229,0.00008382566,0.0001220564],"domain_scores_gemma":[0.9998447,0.000007855463,0.00005008375,0.00006042757,0.000006527257,0.00003041772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006842302,0.00003295515,0.00004235319,0.00001175297,0.000002413694,7.98398e-8,0.00007183749,0.01637427,0.9808668,0.000007967949,0.00008944979,0.002493252],"study_design_scores_gemma":[0.000117443,0.00005107492,0.003771012,0.00003722099,0.000005308887,0.000003923323,0.000003182138,0.01964149,0.9734595,0.000009495514,0.002818534,0.00008182199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9066647,0.00002116641,0.09246957,0.0001107612,0.00005568941,0.000526159,5.814671e-7,0.0000356187,0.000115722],"genre_scores_gemma":[0.9894888,0.000002699507,0.009417625,0.000007231518,0.0000523153,0.0000390947,4.018977e-7,0.0000109002,0.0009808709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08305194,"threshold_uncertainty_score":0.275105,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2110037767","doi":"10.1093/protein/gzi039","title":"Large-scale modelling as a route to multiple surface comparisons of the CCP module family","year":2005,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Medical Research Council; Wellcome Trust","keywords":"Complement (music); Repertoire; Computational biology; Template; Complement system; Surface protein; Computer science; Scale (ratio); Biology; Genetics; Antibody; Phenotype; Geography; Physics; Cartography; Programming language; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01784707529397751,"gpt":0.2170227470767421,"spread":0.1991756717827646,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901727,0.0001106168,0.0001486135,0.00004727279,0.0001163666,0.00001050613,0.00009378212,0.00006237218,0.00002282776],"category_scores_gemma":[0.00002659406,0.00009508894,0.00004029983,0.0001328671,0.0000111406,0.00004969728,0.00003892005,0.0001103193,0.00003440513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004013315,"about_ca_system_score_gemma":0.00001833748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001174147,"about_ca_topic_score_gemma":0.00001653628,"domain_scores_codex":[0.9993243,0.00008037665,0.0001826175,0.0001693359,0.00003773267,0.0002056104],"domain_scores_gemma":[0.9997346,0.00004865545,0.00004539802,0.0001079735,0.00004164503,0.00002173753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003274268,0.00004107927,0.0009423695,0.00001588489,0.00002444825,3.040351e-8,0.0001927704,0.5314819,0.4667494,0.00007722351,0.0003814648,0.00006061452],"study_design_scores_gemma":[0.0006101594,0.00008832765,0.002329336,0.00007989019,0.00002179716,0.000004737654,0.00007115405,0.6764922,0.3127836,0.00001400416,0.007359376,0.0001453653],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4937212,0.0005151444,0.5050851,0.0000397339,0.00005229667,0.0005179406,0.00000611285,0.00005353427,0.000009032695],"genre_scores_gemma":[0.9846714,0.000005468381,0.01491719,0.00001607313,0.00001823906,0.00006323055,0.00000409327,0.00001355492,0.0002907596],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4909502,"threshold_uncertainty_score":0.3877614,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2146452044","doi":"10.1093/protein/gzu011","title":"Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility","year":2014,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Carleton University; University of Ottawa; University of Guelph; National Research Council Canada","funders":"National Research Council Canada","keywords":"Campylobacter jejuni; Proteases; Mutant; Flagellum; Protein engineering; Motility; Protease; Chemistry; Serine protease; Biology; Microbiology; Molecular biology; Biochemistry; Enzyme; Cell biology; Genetics; Bacteria; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01829776054410898,"gpt":0.2351093120191168,"spread":0.2168115514750078,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006858955,0.000161359,0.0002759288,0.0001302165,0.00007937151,0.00002972445,0.00003515278,0.00009206615,0.00002234574],"category_scores_gemma":[0.0005993511,0.0001419683,0.00004764381,0.0001347662,0.00004947185,0.00008577435,0.00002238829,0.0002475957,0.000006882535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007917362,"about_ca_system_score_gemma":0.00001904432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000410171,"about_ca_topic_score_gemma":0.000004434828,"domain_scores_codex":[0.998791,0.0001773767,0.0002227986,0.0002736395,0.0001398604,0.0003953243],"domain_scores_gemma":[0.9995841,0.00002319643,0.00003751133,0.00009799208,0.00007257481,0.0001846604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004569235,0.0001056655,0.002315377,0.0002753865,0.00003328291,0.00000768397,0.00003416313,0.0003088145,0.9927339,0.000178388,0.000114315,0.003436117],"study_design_scores_gemma":[0.008067558,0.02057776,0.1598395,0.001973375,0.0001243144,0.00093282,0.00006456821,0.3813921,0.4009506,0.003052753,0.02186317,0.001161444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.588891,0.00008979254,0.4096786,0.0003762137,0.0000231803,0.0007632261,0.000001134017,0.0001266352,0.00005025022],"genre_scores_gemma":[0.9434054,0.00001384721,0.05612464,0.00005143499,0.0001316855,0.0001177923,0.000007010572,0.00002153738,0.0001266368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5917832,"threshold_uncertainty_score":0.5789299,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2139772422","doi":"10.1093/protein/13.1.59","title":"Tryptophan fluorescence of calmodulin binding domain peptides interacting with calmodulin containing unnatural methionine analogues","year":2000,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Calmodulin; Chemistry; Caldesmon; Norleucine; Tryptophan; Methionine; Peptide; Biochemistry; Binding site; Quenching (fluorescence); Myosin light-chain kinase; Fluorescence; Amino acid; Myosin; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.007334021452755806,"gpt":0.2125856318640867,"spread":0.2052516104113309,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003391552,0.0001737593,0.0001732111,0.0001011467,0.00009788744,0.00002950575,0.00006007573,0.0001090381,0.00001864714],"category_scores_gemma":[0.0000805271,0.0001575908,0.00003844042,0.0002018143,0.00003520378,0.00001856924,0.00001385146,0.0001588824,0.000001017121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002202309,"about_ca_system_score_gemma":0.00003056133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003316596,"about_ca_topic_score_gemma":0.000004860966,"domain_scores_codex":[0.9990887,0.00007992599,0.0002205498,0.0002805507,0.0001210241,0.0002092622],"domain_scores_gemma":[0.9996765,0.00002461407,0.00008059038,0.00008081089,0.00007057462,0.00006690888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003431391,0.00001699905,0.00009185871,0.0000488601,0.0000395903,0.000002867687,0.00009632006,0.02779353,0.9623551,0.00007735932,0.000002794985,0.009131576],"study_design_scores_gemma":[0.0005743106,0.0005774064,0.0003199344,0.0002612833,0.00001364347,0.00005855283,0.00003691776,0.0722965,0.9253156,0.0000255564,0.0002931397,0.0002271415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7723461,0.0003412765,0.2269179,0.00002334538,0.00001695412,0.0003055123,0.000001448048,0.0000335531,0.00001389774],"genre_scores_gemma":[0.9107679,0.00002638547,0.08893357,0.000006802332,0.00008748011,0.00004284153,0.00002315594,0.00002246446,0.00008945235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1384217,"threshold_uncertainty_score":0.6426367,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2081164013","doi":"10.1093/protein/gzu025","title":"Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs","year":2014,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Prodrug; Nitroreductase; Directed evolution; Cell sorting; Chemistry; Gene; Escherichia coli; High-throughput screening; Enzyme; Computational biology; Reporter gene; Protein engineering; DNA; Biochemistry; Biology; Molecular biology; Cell; Gene expression","retraction":null,"screen_n_in":null,"score":{"opus":0.01935837715677106,"gpt":0.2309361019464031,"spread":0.211577724789632,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517615,0.0001042297,0.0001037893,0.00005974951,0.00005417123,0.00001527972,0.00003827168,0.00007301266,0.000001306219],"category_scores_gemma":[0.00007568384,0.00009874436,0.00003255245,0.00008151042,0.00001326313,0.00001094809,0.000016441,0.00004723634,2.18408e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003644473,"about_ca_system_score_gemma":0.0000288977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001287365,"about_ca_topic_score_gemma":0.000008571783,"domain_scores_codex":[0.9994294,0.00001970724,0.00008698369,0.000198609,0.00008255763,0.0001827091],"domain_scores_gemma":[0.9997855,0.00001414022,0.00004121623,0.00006213644,0.00005272802,0.00004425859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003413182,0.00002427965,0.00009421599,0.00009688229,0.00007525917,9.441302e-8,0.00002649635,0.002115007,0.9879798,0.0001860792,0.00002331833,0.009037206],"study_design_scores_gemma":[0.000770191,0.0005385187,0.0009237554,0.00003310786,0.00001190591,0.000004155298,0.000004233332,0.03138132,0.9654874,0.0001332627,0.0006080064,0.0001041982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3066102,0.0003418594,0.6923536,0.0000137485,0.00001645548,0.0006255487,0.000003125175,0.00003185536,0.000003612561],"genre_scores_gemma":[0.9664073,0.00003116408,0.03304753,0.000002038085,0.00008330453,0.0003313902,0.00002242207,0.00001864606,0.00005618703],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6597971,"threshold_uncertainty_score":0.4026678,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2610202041","doi":"10.1093/protein/gzx025","title":"Quercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant","year":2017,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Chemistry; Quercitrin; SOD1; Biochemistry; Mutant; Protein aggregation; Superoxide dismutase; Quercetin; Dimer; Isothermal titration calorimetry; Oxidative stress; Antioxidant; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.03427525418225021,"gpt":0.2862834128271263,"spread":0.2520081586448761,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004507418,0.0001377235,0.0001777046,0.0000513009,0.0003495325,0.0001414682,0.00005989362,0.0001020684,0.00001144075],"category_scores_gemma":[0.0004731566,0.0000971062,0.00003357824,0.00004594615,0.00006691899,0.0001098012,0.00004404246,0.0002212145,0.000002091709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006218823,"about_ca_system_score_gemma":0.00003450791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893541,"about_ca_topic_score_gemma":0.000002457113,"domain_scores_codex":[0.9991646,0.0000209811,0.0001415793,0.0002373002,0.000157926,0.0002776557],"domain_scores_gemma":[0.9995468,0.00009965695,0.00004471869,0.0001409825,0.00006284345,0.0001049801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002271849,0.00001538127,0.00009878138,0.0001009817,0.00003693087,0.00000321281,0.00008709585,0.0001351966,0.9895369,0.0002998054,0.00001385768,0.009444665],"study_design_scores_gemma":[0.001651442,0.000481528,0.01751958,0.0003194457,0.00007131069,0.0002324009,0.00001539863,0.3733631,0.6047962,0.0002839107,0.001019639,0.0002459924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8281941,0.0004237331,0.1674771,0.002123823,0.00003909879,0.001642832,6.142542e-7,0.00008273619,0.00001599185],"genre_scores_gemma":[0.9898838,0.0001755287,0.00916148,0.00003090717,0.0002110482,0.0002911275,0.000001115871,0.00002955493,0.0002154423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3847407,"threshold_uncertainty_score":0.3959876,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2165984662","doi":"10.1093/protein/gzl037","title":"Improving solubility and refolding efficiency of human VHs by a novel mutational approach","year":2006,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Biotechnology Research Institute; National Research Council Canada; Institute for Biological Sciences","funders":"National Research Council Canada","keywords":"Immunogenicity; Solubility; Recombinant DNA; Chemistry; Mutation; Denaturation (fissile materials); Sequence (biology); Antibody; Computational biology; Combinatorial chemistry; Biophysics; Biochemistry; Biology; Genetics; Organic chemistry; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01410096382370732,"gpt":0.2399245589658144,"spread":0.2258235951421071,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003005208,0.0000936237,0.0001405742,0.00009210918,0.00009370816,0.00001558747,0.00002177976,0.00005374612,0.000004755147],"category_scores_gemma":[0.00004107502,0.00008274824,0.00002227657,0.0001427861,0.00004064356,0.00005124989,0.00001579237,0.00013322,1.691471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003004267,"about_ca_system_score_gemma":0.00002300342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005138519,"about_ca_topic_score_gemma":8.846441e-7,"domain_scores_codex":[0.9993007,0.00001555254,0.0001652259,0.000187402,0.0001713403,0.0001597976],"domain_scores_gemma":[0.9997861,0.00003361746,0.00003558881,0.00003587747,0.00005822773,0.00005057427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005912039,0.0001074143,0.0006049032,0.0003652312,0.00001149268,5.51609e-7,0.00003404171,0.0006422868,0.9963568,0.0008001092,0.00001592999,0.001002073],"study_design_scores_gemma":[0.0007889047,0.0004783113,0.008289344,0.00006590599,0.00002065271,0.00008538758,0.00001066852,0.5698747,0.4200675,0.0001125046,0.00006171202,0.0001444449],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6145491,0.0003406186,0.3846583,0.00002696488,0.000005511995,0.0003263498,0.00000174947,0.00002868375,0.00006272768],"genre_scores_gemma":[0.9682124,0.000004173247,0.03138017,0.000003288791,0.00005247618,0.00003832441,0.00001281973,0.00001033517,0.0002860439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5762894,"threshold_uncertainty_score":0.3374375,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2137718639","doi":"10.1093/protein/15.7.561","title":"Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical","year":2002,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":40,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Azobenzene; Steric effects; Linker; Helix (gastropod); Chemistry; Peptide; Crystallography; Stereochemistry; Biochemistry; Molecule; Computer science; Organic chemistry; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.04705214105737452,"gpt":0.2591396942431305,"spread":0.212087553185756,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752528,0.0001569654,0.0001971491,0.00004828799,0.0001207825,0.0001065454,0.00008297058,0.00006753433,0.00009770349],"category_scores_gemma":[0.00009731862,0.0001421911,0.00002366238,0.00009883047,0.00006492787,0.0003425598,0.00001011722,0.000152446,0.000003590043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006090334,"about_ca_system_score_gemma":0.00001203744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005282976,"about_ca_topic_score_gemma":0.000003709865,"domain_scores_codex":[0.9990679,0.00003804779,0.0002251097,0.000277003,0.000153426,0.0002385064],"domain_scores_gemma":[0.9995462,0.00006927659,0.00007543579,0.0001007902,0.0001075236,0.0001007523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437656,0.00007657923,0.0001464772,0.0001056351,0.000009515079,0.000002402663,0.0001058106,0.001728312,0.9975501,0.00001817445,0.00001871334,0.00009457152],"study_design_scores_gemma":[0.0004734918,0.0002214841,0.0006003302,0.000156185,0.00001489226,0.00003872683,0.00004070718,0.1182006,0.8800653,0.000009636888,0.00002240794,0.0001562663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6383911,0.0001163113,0.3610443,0.00003435057,0.0000324203,0.0002772325,0.00000658335,0.00008895125,0.000008704237],"genre_scores_gemma":[0.9914868,0.00001104644,0.008132877,0.00002368206,0.00004012317,0.0001446893,0.000001716007,0.00002145891,0.0001376374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3530957,"threshold_uncertainty_score":0.5798383,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2105721912","doi":"10.1093/protein/gzi037","title":"Computational modeling of type I collagen fibers to determine the extracellular matrix structure of connective tissues","year":2005,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Collagen: Extraction and Characterization","field":"Materials Science","cited_by":39,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Toronto Western Hospital","funders":"","keywords":"Extracellular matrix; Fibril; Triple helix; Matrix (chemical analysis); Amino acid; Chemistry; Biological system; Sequence (biology); Biophysics; Materials science; Composite material; Biochemistry; Stereochemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.01300661938848447,"gpt":0.2289337617056131,"spread":0.2159271423171286,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433475,0.00007828921,0.0001047952,0.00007421086,0.00005531915,0.00002247888,0.00004691006,0.00004327775,0.00007847838],"category_scores_gemma":[0.00005116459,0.00006722542,0.00001355889,0.0002139491,0.00001021134,0.00009938878,0.00001000125,0.00003287489,0.000002275945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002960736,"about_ca_system_score_gemma":0.00002555797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001277236,"about_ca_topic_score_gemma":0.000002880486,"domain_scores_codex":[0.9994551,0.00003654489,0.0001831951,0.000118835,0.0001221542,0.00008415651],"domain_scores_gemma":[0.9996775,0.00003980373,0.00006740262,0.00004466987,0.0001419579,0.000028655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003407331,0.00000522015,0.000002140943,0.00001463261,0.000003290319,7.238427e-8,0.0002346813,0.4790045,0.5202227,0.0001036057,0.000002783604,0.0003722755],"study_design_scores_gemma":[0.00007649661,0.00006327521,0.00004164473,0.00001553305,0.000006434615,0.000005792713,0.0000168531,0.5962766,0.4033146,0.00003910574,0.00009680661,0.00004685974],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5700457,0.0001026402,0.4294643,0.00004358252,0.00003506451,0.0002827113,0.000002659825,0.00002179447,0.000001641433],"genre_scores_gemma":[0.9549183,0.000003804301,0.04491076,0.000004910879,0.00005380133,0.000009988554,0.000003259387,0.000009544287,0.00008558002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3848727,"threshold_uncertainty_score":0.2741373,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2127635544","doi":"10.1093/protein/gzg134","title":"The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5","year":2003,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"University of British Columbia; National Natural Science Foundation of China","keywords":"Heme; Mutant; Cytochrome b5; Cytochrome; Chemistry; Mutagenesis; Hemeprotein; Ferrous; Ferric; Ligand (biochemistry); Cytochrome b; Biochemistry; Stereochemistry; Gene; Receptor; Enzyme; Inorganic chemistry; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.005355110747020527,"gpt":0.1802910982448618,"spread":0.1749359874978412,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086491,0.00008668681,0.00008635878,0.00002796017,0.00006933771,0.0000104997,0.00001879341,0.00006694678,0.000002079329],"category_scores_gemma":[0.00009541516,0.00007204929,0.00001256498,0.0000488464,0.00004825419,0.00000797636,0.00001200705,0.00004381651,6.001923e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001338962,"about_ca_system_score_gemma":0.000009870462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000493356,"about_ca_topic_score_gemma":0.000001264966,"domain_scores_codex":[0.9995351,0.00003747849,0.0001296698,0.0001376688,0.0000633594,0.00009666465],"domain_scores_gemma":[0.9998305,0.00001959158,0.0000523031,0.00005284727,0.00001905609,0.00002565491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003680056,0.000007116519,0.0009828932,0.00005098911,0.0000205898,7.808784e-8,0.00004540849,0.0001091288,0.9971884,0.0001554949,0.000005285755,0.00139783],"study_design_scores_gemma":[0.0003459721,0.0003361803,0.006639097,0.00001950366,0.00001581922,0.00001907469,0.00004164466,0.001851492,0.9890889,0.000139868,0.001397409,0.0001050384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8945963,0.0006215732,0.1044753,0.000008446122,0.0000256224,0.0002517155,0.000001958871,0.000004898228,0.00001418157],"genre_scores_gemma":[0.9978408,0.00009609709,0.001892204,0.000001550678,0.00001696698,0.00001803542,0.000004017586,0.000008996115,0.0001213419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032444,"threshold_uncertainty_score":0.2938085,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3194401934","doi":"10.1093/protein/gzab021","title":"Engineering stable carbonic anhydrases for CO2 capture: a critical review","year":2021,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Waterloo","funders":"","keywords":"Computational biology; Phage display; Protein engineering; Drug discovery; Structural similarity; Similarity (geometry); Computer science; Protein design; Chemistry; Protein structure; Biology; Combinatorial chemistry; Biochemistry; Artificial intelligence; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.02784295521283906,"gpt":0.2730007726076218,"spread":0.2451578173947828,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003184989,0.0003298536,0.000615892,0.00008460204,0.00006258868,0.00004920029,0.00005659796,0.000322276,0.00001962686],"category_scores_gemma":[0.0007169213,0.0003288139,0.0002101846,0.0002047964,0.00001172523,0.000008342414,0.00002575316,0.0002208222,0.000001773742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005546132,"about_ca_system_score_gemma":0.0001521038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003830154,"about_ca_topic_score_gemma":6.678305e-7,"domain_scores_codex":[0.9987945,0.00006974197,0.0003137699,0.0004523749,0.00009283462,0.0002767696],"domain_scores_gemma":[0.9995368,0.00005915131,0.00006478157,0.0001348798,0.0001120571,0.00009238112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009635569,0.0003983687,6.665306e-7,0.5090093,0.001421106,0.00002577838,0.0000314768,0.006857515,0.1716215,0.003691745,0.05158942,0.2552568],"study_design_scores_gemma":[0.0001251461,0.0001723312,4.794271e-8,0.01643615,0.0003049928,0.0001087361,7.794483e-7,0.002543501,0.004447849,0.000002111811,0.9754677,0.0003906511],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001482205,0.7053043,0.2935026,0.00001689947,0.0001130693,0.000999516,0.000009499002,0.0000454124,0.000007246474],"genre_scores_gemma":[0.00003553005,0.9888386,0.008660922,0.00004423295,0.0003295768,0.001312738,0.0002817048,0.00007671711,0.0004200182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9238783,"threshold_uncertainty_score":0.9999164,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2157792089","doi":"10.1093/protein/gzs014","title":"A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Carleton University; University of Guelph; National Research Council Canada; Institute for Biological Sciences; Steacie Institute for Molecular Sciences; University of Ottawa","funders":"","keywords":"Antigen; Phage display; Yield (engineering); Computational biology; Peptide library; Recombinant DNA; Complementarity (molecular biology); Chemistry; Antibody; Combinatorial chemistry; Biology; Genetics; Biochemistry; Materials science; Peptide sequence; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.03387472348733665,"gpt":0.2516800868673859,"spread":0.2178053633800492,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003199242,0.000194676,0.0002531465,0.000216158,0.0001330694,0.00005753974,0.00005518896,0.00008981971,0.00007638388],"category_scores_gemma":[0.0001469254,0.0001678801,0.00004694642,0.0003946764,0.0000215903,0.0002704966,0.00005920166,0.0003106248,0.00002841568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004429251,"about_ca_system_score_gemma":0.00004028323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009894299,"about_ca_topic_score_gemma":0.000001529585,"domain_scores_codex":[0.9987937,0.00004211429,0.0001853604,0.0002393837,0.0002446508,0.0004947559],"domain_scores_gemma":[0.9994201,0.00008944893,0.00003265658,0.00007599464,0.00003905658,0.0003427347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003601999,0.0001059915,0.004750762,0.000214307,0.00005207269,0.00001401348,0.0002545,0.0002996248,0.9898465,0.0001798136,0.0002736752,0.003648497],"study_design_scores_gemma":[0.0009026823,0.002074494,0.03545395,0.001121046,0.00005455668,0.0003848934,0.00006625069,0.03095203,0.9232138,0.00008997311,0.00500366,0.0006826318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8433782,0.0002529649,0.1541416,0.0007400493,0.00006975964,0.001071332,0.000001705534,0.0001560192,0.0001883596],"genre_scores_gemma":[0.9354141,0.00001724095,0.06272143,0.0001517676,0.000403633,0.00007499939,0.000007567886,0.00004107648,0.001168165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09203587,"threshold_uncertainty_score":0.6845951,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2267572915","doi":"10.1093/protein/gzv039","title":"Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing","year":2015,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; Wilfrid Laurier University; University of Guelph; National Research Council Canada","funders":"","keywords":"Panning (audio); Single-domain antibody; Phage display; Antibody; Computational biology; Biology; Molecular biology; Albumin; DNA; Peptide library; DNA sequencing; Bovine serum albumin; Biochemistry; Gene; Genetics; Peptide sequence","retraction":null,"screen_n_in":null,"score":{"opus":0.1277437226061514,"gpt":0.3154302713175416,"spread":0.1876865487113902,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005820003,0.0001479296,0.0002146717,0.0002075844,0.00009467965,0.00007293495,0.00003704995,0.00009323951,0.000002799878],"category_scores_gemma":[0.0001950048,0.0001401209,0.00004144398,0.000267192,0.00005596595,0.0003181914,0.00001922871,0.0001569057,0.000002379101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246018,"about_ca_system_score_gemma":0.0001217339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007119996,"about_ca_topic_score_gemma":0.000002525491,"domain_scores_codex":[0.9988979,0.00006469626,0.0003069966,0.0002282301,0.000286203,0.0002160456],"domain_scores_gemma":[0.9993593,0.00003072363,0.0001004544,0.00007418475,0.000316994,0.0001183748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001430886,0.00004060537,0.0008357204,0.000136008,0.00004552759,0.000004652495,0.0003795499,0.01272055,0.9842167,0.0001206205,0.000007935887,0.001349011],"study_design_scores_gemma":[0.0003007265,0.0001676868,0.0008747143,0.00008116314,0.00001448472,0.00004347558,0.00004477098,0.3502053,0.6480768,0.00005660388,0.00003981302,0.00009451168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8434351,0.0002950392,0.155547,0.00005905604,0.00006225669,0.0005188631,0.000002926865,0.00004979795,0.000029949],"genre_scores_gemma":[0.9830247,0.0000199476,0.01645864,0.00001102504,0.0002055541,0.00002177053,0.00001592777,0.00002317198,0.0002193022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3374847,"threshold_uncertainty_score":0.5713965,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2105464215","doi":"10.1093/protein/gzs055","title":"Disulfide linkage engineering for improving biophysical properties of human VH domains","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa; University of Guelph; National Research Council Canada","funders":"","keywords":"Linkage (software); Disulfide bond; Disulfide Linkage; Chemistry; Computational biology; Combinatorial chemistry; Biochemistry; Biology; Cysteine; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.01903967436920555,"gpt":0.2235577712318803,"spread":0.2045180968626747,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465102,0.0001373893,0.0002508059,0.0001019502,0.00007516844,0.00001090734,0.00002034148,0.00006329111,6.60016e-7],"category_scores_gemma":[0.0001424788,0.0001194794,0.00007207959,0.0001236746,0.00001830091,0.0001028675,0.00001705178,0.0001094729,3.939525e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004101745,"about_ca_system_score_gemma":0.00001135388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001159533,"about_ca_topic_score_gemma":1.33949e-7,"domain_scores_codex":[0.9993609,0.000009980259,0.0001630633,0.0001277269,0.00009263791,0.0002457221],"domain_scores_gemma":[0.999737,0.00002487029,0.00003470063,0.00005990833,0.00007145567,0.00007201402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006338547,0.00004755063,0.0001370834,0.0008664196,0.0000572611,3.646738e-7,0.0003148088,0.0004055874,0.9966861,0.0005006549,0.000005689159,0.0009151067],"study_design_scores_gemma":[0.0006650306,0.0003969321,0.002301472,0.0002248084,0.0001191434,0.0000257427,0.00003173211,0.03169217,0.9641507,0.000006776044,0.0002200115,0.0001655355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.649437,0.0008527672,0.3487354,0.00002028624,0.00006160094,0.0007788333,8.300091e-7,0.0001078746,0.000005448655],"genre_scores_gemma":[0.9848303,0.00001007481,0.01438604,0.000005106217,0.0003902135,0.0002848053,0.00000171361,0.00002880323,0.00006296687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3353933,"threshold_uncertainty_score":0.4872229,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2153606417","doi":"10.1093/protein/13.9.611","title":"Functional EGFP–dystrophin fusion proteins for gene therapy vector development","year":2000,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Dystrophin; Green fluorescent protein; Molecular biology; Transfection; Duchenne muscular dystrophy; Fusion protein; Biology; Transduction (biophysics); Electroporation; Transgene; Utrophin; Viral vector; Fusion gene; Complementary DNA; Genetic enhancement; Cell biology; Gene; Biochemistry; Recombinant DNA; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.01210720749064921,"gpt":0.2059468446347275,"spread":0.1938396371440783,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138547,0.0001511085,0.00008606204,0.00004241101,0.0001846858,0.00003444374,0.00003971443,0.0001069538,0.00007675883],"category_scores_gemma":[0.00001974895,0.0001407486,0.00004558613,0.00007056603,0.00001016329,0.000007214622,0.00001000394,0.00005789716,0.000004805357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002099004,"about_ca_system_score_gemma":0.00005205833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007534675,"about_ca_topic_score_gemma":9.670485e-7,"domain_scores_codex":[0.9992883,0.00002486675,0.0001371443,0.000276058,0.00008653932,0.0001870578],"domain_scores_gemma":[0.9997743,0.000005929659,0.00002801008,0.00006793503,0.00005179832,0.00007198305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004050903,0.00005759755,0.00002426807,0.00002096941,0.0000329681,2.297273e-7,0.00001728246,0.01042883,0.9726197,0.00001448106,0.0004182846,0.01596029],"study_design_scores_gemma":[0.0007958753,0.0006546737,0.001259234,0.00002200964,0.000004748503,0.00001339371,0.000001118883,0.006949321,0.9526224,0.00003487861,0.03742612,0.0002161905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5685678,0.0005861734,0.4298982,0.00002317702,0.00005890692,0.0008083653,0.000002092788,0.0000468834,0.000008392652],"genre_scores_gemma":[0.9531598,0.0001695158,0.04381387,0.00004552848,0.0004100984,0.001196405,0.00005283641,0.00003529394,0.001116645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3860843,"threshold_uncertainty_score":0.5739561,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2102297470","doi":"10.1093/protein/14.9.669","title":"N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pepsin; Chemistry; Zymogen; Enzyme; Mutant; Protease; Peptide; Dissociation (chemistry); Biochemistry; Organic chemistry","retraction":null,"screen_n_in":null,"score":{"opus":0.0116265642940884,"gpt":0.2060745927862941,"spread":0.1944480284922057,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110901,0.00008239177,0.0001119361,0.00005998679,0.00007915219,0.000005214874,0.00004068263,0.00009787446,0.0000275461],"category_scores_gemma":[0.00002927533,0.00006758388,0.00002925216,0.0001055488,0.0000444758,0.000153195,0.00001483766,0.000103212,0.000001729021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000278097,"about_ca_system_score_gemma":0.00002111973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008291534,"about_ca_topic_score_gemma":0.000005428502,"domain_scores_codex":[0.9995653,0.00005775331,0.000143126,0.0001015216,0.00002010083,0.000112214],"domain_scores_gemma":[0.9997754,0.000019837,0.0001045057,0.00005203553,0.00003902,0.000009225208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813959,0.00004447478,0.0002731498,0.00003130288,0.00001804092,3.893353e-7,0.0001476325,0.0007615764,0.9971104,0.0005724624,0.00001274906,0.0008463893],"study_design_scores_gemma":[0.000264044,0.0002492617,0.007217007,0.00005602602,0.00001443469,0.000129929,0.0000261345,0.0006343492,0.9910401,0.00009241518,0.0002035336,0.00007276007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863119,0.00006108887,0.01320442,0.00002887067,0.00007416815,0.0002523284,0.000001251548,0.00002691679,0.00003907442],"genre_scores_gemma":[0.9992115,0.0000161638,0.000391235,0.000008157574,0.00002009797,0.00001180296,0.000006097625,0.000008750428,0.0003261862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01289963,"threshold_uncertainty_score":0.2755991,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2167917021","doi":"10.1093/protein/gzr004","title":"Modulating the pH-activity profile of cellulase A from Cellulomonas fimi by replacement of surface residues","year":2011,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cellulase; Chemistry; Glycoside hydrolase; Enzyme; Cellulose; Biochemistry; Cysteine; Hydrolysis; Cellulosic ethanol; Amino acid","retraction":null,"screen_n_in":null,"score":{"opus":0.01287316564390028,"gpt":0.1866994741051367,"spread":0.1738263084612365,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673712,0.00008070832,0.00007922958,0.00001561168,0.00003545776,0.000005127947,0.00003941304,0.00005839535,0.00001395412],"category_scores_gemma":[0.0000365156,0.00006981593,0.00001963343,0.00006883923,0.00001865146,0.000007035052,0.00001724496,0.00005204152,2.525951e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000625192,"about_ca_system_score_gemma":0.00001267638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009243681,"about_ca_topic_score_gemma":0.000001273236,"domain_scores_codex":[0.9995092,0.000054195,0.0001298411,0.0001644718,0.00006512303,0.00007719469],"domain_scores_gemma":[0.9997295,0.000006622866,0.00009863287,0.00009611508,0.00004989134,0.00001929368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001482703,0.00004090351,0.0002578105,0.0000333658,0.00002227032,4.046846e-8,0.0001416141,0.001061567,0.9978524,0.000009307804,0.00005694353,0.0003755194],"study_design_scores_gemma":[0.0001433281,0.0002048872,0.0007489335,0.00001543189,0.000008840491,8.053178e-7,0.00001246108,0.01942448,0.9791932,0.00001098326,0.0001660562,0.0000705603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7584739,0.0001861496,0.2410123,0.00001419269,0.00002386502,0.0002591877,0.000004961457,0.00001129306,0.00001409144],"genre_scores_gemma":[0.9915862,0.00003234407,0.008107459,0.000003166978,0.00003231796,0.0000252791,0.00002282966,0.00001177752,0.0001786459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2331122,"threshold_uncertainty_score":0.2847011,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W1884499457","doi":"10.1093/protein/gzv055","title":"Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display","year":2015,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; University of Toronto; University of Missouri","keywords":"KEAP1; Phage display; Ubiquitin; Transcription factor; Chemistry; Cysteine; Transcription (linguistics); Computational biology; Cell biology; Biology; Gene; Biochemistry; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.008865696954672682,"gpt":0.2012939879018207,"spread":0.192428290947148,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515883,0.0001624335,0.0001331503,0.00004619654,0.00003719697,0.00002289874,0.00006710312,0.0001077885,0.000001776232],"category_scores_gemma":[0.0001309311,0.0001402389,0.00003101023,0.00008384166,0.00003953293,0.000008377586,0.00003515253,0.0001247133,2.562169e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002771662,"about_ca_system_score_gemma":0.0000408919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007108034,"about_ca_topic_score_gemma":0.000001454052,"domain_scores_codex":[0.9992976,0.00006242748,0.000160617,0.000237258,0.00009001007,0.0001520922],"domain_scores_gemma":[0.9996474,0.00002732979,0.00006354263,0.00009175359,0.00009137877,0.00007853624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001221295,0.0000172365,0.00005607372,0.00004204779,0.0000268458,2.283819e-7,0.00007131453,0.06922308,0.9300867,0.00003618173,0.000008964519,0.0003091738],"study_design_scores_gemma":[0.0004304479,0.0002117383,0.0002894104,0.00003912548,0.0000149189,0.000009504989,0.00000803314,0.1789722,0.8196647,0.00003127771,0.0002005411,0.0001281598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4087089,0.0001596477,0.5906674,0.00001758385,0.00006042318,0.0003685287,0.000002953173,0.00001156902,0.000003015237],"genre_scores_gemma":[0.9552268,0.000008517864,0.044556,0.00001513499,0.0001056039,0.0000454631,0.000008737615,0.00002119434,0.00001248892],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.546518,"threshold_uncertainty_score":0.5718778,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2098512467","doi":"10.1093/protein/gzi055","title":"N-Glycosidase–carbohydrate-binding module fusion proteins as immobilized enzymes for protein deglycosylation","year":2005,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; Heritage Medical Research Clinic","funders":"","keywords":"Glycan; Chemistry; Carbohydrate-binding module; Glycoside hydrolase; Biochemistry; Glycoprotein; Thermostability; Affinity chromatography; Fusion protein; Enzyme; Escherichia coli; Chromatography; Recombinant DNA","retraction":null,"screen_n_in":null,"score":{"opus":0.008151628665399683,"gpt":0.2146824179128443,"spread":0.2065307892474446,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000306149,0.0002058671,0.0001339996,0.0001229992,0.0001747651,0.00007794168,0.00006012959,0.0001797956,0.00001390067],"category_scores_gemma":[0.0001617216,0.0002178889,0.00005147178,0.0001687636,0.00001459745,0.00003489367,0.00002293595,0.0001007965,0.000006791484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004735482,"about_ca_system_score_gemma":0.00004332134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006845488,"about_ca_topic_score_gemma":0.000002575949,"domain_scores_codex":[0.9989325,0.00005399378,0.000233112,0.0004170071,0.0001159525,0.0002473994],"domain_scores_gemma":[0.9995947,0.000006021709,0.00009292205,0.0001137213,0.0001174001,0.00007524234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458241,0.00005397263,0.00001029029,0.0000644998,0.00002144275,1.30141e-7,0.00002908851,0.006099133,0.9886943,0.0004312028,0.00002972878,0.004320427],"study_design_scores_gemma":[0.0006889153,0.0004523739,0.00004667355,0.00004348173,0.00001247027,0.00001045653,0.000005176495,0.06254262,0.9281778,0.00005856335,0.007715656,0.0002458173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5744925,0.0001833248,0.4232034,0.0001477637,0.00004556338,0.001830229,0.00000217604,0.00008556279,0.000009393718],"genre_scores_gemma":[0.9583985,0.00002919613,0.03854201,0.00002341287,0.0004541996,0.001382499,0.0001067315,0.00004991172,0.001013567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3846614,"threshold_uncertainty_score":0.8885249,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2132425142","doi":"10.1093/protein/gzm066","title":"Expression and enzymatic characterization of the soluble recombinant plasmepsin I from Plasmodium falciparum","year":2007,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Malaria Research and Control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Recombinant DNA; Plasmodium falciparum; Escherichia coli; Biochemistry; Chemistry; Enzyme; Size-exclusion chromatography; Hemoglobin; Affinity chromatography; Malaria vaccine; Fusion protein; Biology","retraction":null,"screen_n_in":null,"score":{"opus":0.01175312455663224,"gpt":0.2153840572354003,"spread":0.2036309326787681,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000321605,0.00008114075,0.0001308741,0.00007330465,0.0000588883,0.00001585566,0.0000280633,0.00006961003,0.00001093674],"category_scores_gemma":[0.0001044189,0.00005805696,0.00001854293,0.0001178635,0.00001436406,0.00006343315,0.00001667694,0.0001359287,6.059423e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000235941,"about_ca_system_score_gemma":0.00002511593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002835077,"about_ca_topic_score_gemma":0.000001630116,"domain_scores_codex":[0.9993963,0.00003234629,0.0001521518,0.0001229682,0.0001383034,0.0001579951],"domain_scores_gemma":[0.9997314,0.00004976802,0.00004802007,0.00006452853,0.00003863552,0.00006763753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002970748,0.00002986156,0.0002647795,0.00008087123,0.00001474196,7.827233e-7,0.00008649872,0.00004072585,0.996956,0.0001269657,0.000006781985,0.00209492],"study_design_scores_gemma":[0.0009955765,0.0002148068,0.02913354,0.0002335355,0.00001861828,0.00001079331,0.000007730703,0.1070282,0.8620678,0.0001114866,0.0001121958,0.00006572965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6793787,0.00007111124,0.3195636,0.0002057994,0.00006486958,0.000676448,6.111495e-7,0.00002888628,0.000009946997],"genre_scores_gemma":[0.9954175,0.00002142196,0.004224892,0.000009757524,0.00004100266,0.00004331063,0.000004310212,0.00001133964,0.0002264726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3160387,"threshold_uncertainty_score":0.2367494,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2138586548","doi":"10.1093/protein/gzs045","title":"Directed evolution of a  -glycosidase from Agrobacterium sp. to enhance its glycosynthase activity toward C3-modified donor sugars","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Glycoside hydrolase; Directed evolution; Glycosyl; Glycan; Chemistry; Mutant; Biochemistry; Enzyme; Mutagenesis; Glycoside; Stereochemistry; Saturated mutagenesis; Monosaccharide; Glycosyltransferase; Gene; Glycoprotein","retraction":null,"screen_n_in":null,"score":{"opus":0.01355421591649439,"gpt":0.2178763167891046,"spread":0.2043221008726102,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001818236,0.0002454905,0.0002736842,0.00007846364,0.00006002077,0.00003187005,0.00008563937,0.0001902247,0.0001276813],"category_scores_gemma":[0.000302147,0.0002696821,0.00006467001,0.0002679346,0.00001382378,0.0002355283,0.0000309336,0.0001892052,0.000006937122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229587,"about_ca_system_score_gemma":0.00003258466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001824725,"about_ca_topic_score_gemma":0.000002268968,"domain_scores_codex":[0.9989157,0.00003501839,0.0002243675,0.0003113067,0.0001597284,0.0003538789],"domain_scores_gemma":[0.9993594,0.0001130797,0.00009565581,0.0001477493,0.00007741866,0.0002067181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003851037,0.0001223416,0.0000585649,0.000232318,0.00005120581,0.000001056912,0.0001694912,0.0008208203,0.9958414,0.00001126991,0.000009876257,0.002296597],"study_design_scores_gemma":[0.0001878987,0.00002690498,0.0004833696,0.0001310291,0.00004082224,0.000006034369,0.00001053435,0.02774364,0.9710075,0.00001054723,0.0000698738,0.000281889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8769202,0.0002325689,0.1221944,0.00002300446,0.00005886872,0.0002385538,0.00002382704,0.0002359636,0.00007253254],"genre_scores_gemma":[0.9955171,0.00001395776,0.003912375,0.000002281637,0.000200126,0.0001977521,0.00001010008,0.00003255223,0.0001136986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1185969,"threshold_uncertainty_score":0.9999756,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2101763866","doi":"10.1093/protein/gzt052","title":"Circular permutated red fluorescent proteins and calcium ion indicators based on mCherry","year":2013,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"mCherry; Fluorescence; Fluorescent protein; Green fluorescent protein; Biophysics; Calmodulin; Calcium; Directed evolution; Phototoxicity; Fusion protein; Chemistry; Biology; Biochemistry; Computational biology; Recombinant DNA; Mutant; Optics; Gene; In vitro; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.006432532036446647,"gpt":0.2154521213689298,"spread":0.2090195893324831,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286581,0.0001776636,0.0001067589,0.0001327406,0.00007652671,0.00003751806,0.00005269201,0.0001688253,0.00000567594],"category_scores_gemma":[0.00007535259,0.0001760096,0.00002341671,0.0001480745,0.00003414787,0.00001056948,0.00002023838,0.0001498308,0.000001490348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003649878,"about_ca_system_score_gemma":0.00002572073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000159564,"about_ca_topic_score_gemma":2.344176e-7,"domain_scores_codex":[0.9991878,0.00004654254,0.0001285431,0.0003305239,0.00009086624,0.0002157172],"domain_scores_gemma":[0.9997155,0.000005828485,0.00004157989,0.0001075047,0.00004327666,0.00008633107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004125146,0.00002966732,0.0001799546,0.00004653485,0.000009483441,7.583085e-7,0.00001248268,0.001659072,0.9960753,0.00001133732,0.0000474448,0.001886743],"study_design_scores_gemma":[0.000258599,0.0004685606,0.001470671,0.00005969408,0.000005400368,0.000006442729,0.000002874937,0.06085777,0.9362434,0.00002790374,0.0004030464,0.0001957021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2611979,0.0001651777,0.7371709,0.00007286557,0.00001738407,0.001260956,8.158129e-7,0.0001078049,0.000006194776],"genre_scores_gemma":[0.9168602,0.00002529665,0.08245394,0.00003806363,0.00004797424,0.0004967092,0.00001368765,0.0000353269,0.00002883826],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6556622,"threshold_uncertainty_score":0.7177464,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2097062325","doi":"10.1093/protein/14.5.367","title":"Investigation of the `switch-epitope' concept with random peptide libraries displayed as thioredoxin loop fusions","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Epitope; Peptide; Chemistry; Affinity chromatography; Epitope mapping; Thioredoxin; Avidity; Monoclonal antibody; Biochemistry; Polyclonal antibodies; Linear epitope; Histidine; Molecular biology; Biotinylation; Antibody; Mutagenesis; Peptide sequence; Biology; Amino acid; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.01556555080674281,"gpt":0.2227313100949582,"spread":0.2071657592882154,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544441,0.0001202632,0.0001736159,0.00007196166,0.0001298193,0.00002478258,0.00005139954,0.00005996851,0.00003306448],"category_scores_gemma":[0.0001556973,0.0000722402,0.00003767084,0.0003826894,0.00009898423,0.0001052761,0.00002305112,0.0002108229,0.000002250125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756553,"about_ca_system_score_gemma":0.00009971124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001447442,"about_ca_topic_score_gemma":0.000004792763,"domain_scores_codex":[0.9992369,0.00006057149,0.00015221,0.0001459823,0.0002365313,0.0001678437],"domain_scores_gemma":[0.9995845,0.00009179911,0.00004514019,0.00007732237,0.0001087484,0.00009247037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002059919,0.0000342269,0.009482414,0.0001622475,0.0001003589,0.000008991519,0.0006170138,0.002805213,0.980261,0.001930828,0.0002116062,0.002326234],"study_design_scores_gemma":[0.003529817,0.001425161,0.04646791,0.0007299446,0.00009966096,0.0002900705,0.00008012334,0.08301898,0.8600963,0.0006589256,0.003312747,0.0002903237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489449,0.0004961825,0.04841585,0.0009410871,0.00003573335,0.0009908724,0.000001190972,0.00005830904,0.0001159187],"genre_scores_gemma":[0.9919078,0.0001106273,0.005224593,0.00005579002,0.0001135166,0.00007740127,0.000005725572,0.00001735825,0.002487183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1201646,"threshold_uncertainty_score":0.294587,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2133297402","doi":"10.1093/protein/gzs075","title":"Polysaccharide co-polymerases: the enigmatic conductors of the O-antigen assembly orchestra","year":2012,"lang":"en","type":"review","venue":"Protein Engineering Design and Selection","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":25,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Saskatchewan; Western University; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Periplasmic space; Polysaccharide; Bacteria; Chemistry; Function (biology); Bacterial outer membrane; Biology; Biochemistry; Microbiology; Cell biology; Genetics; Gene; Escherichia coli","retraction":null,"screen_n_in":null,"score":{"opus":0.03886487282035246,"gpt":0.2663119181849372,"spread":0.2274470453645848,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002796377,0.0002318791,0.0003496905,0.00004031596,0.0001454299,0.00004413159,0.0002013952,0.0001295631,0.0001864151],"category_scores_gemma":[0.0000323627,0.0001324587,0.0001482573,0.0002743565,0.00006090451,0.000135196,0.00005149978,0.0003392625,0.00002892175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009930855,"about_ca_system_score_gemma":0.00002827336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002185869,"about_ca_topic_score_gemma":0.000005702812,"domain_scores_codex":[0.9990514,0.0001463962,0.0002962368,0.0001776381,0.0001110887,0.0002172521],"domain_scores_gemma":[0.9994999,0.00009567113,0.0001960468,0.0001552167,0.000005631491,0.00004751482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005267475,0.00007547348,0.00001322153,0.002287652,0.0001978711,5.498141e-7,0.0003883039,0.0003308471,0.6819623,0.00005592516,0.0001596976,0.3145229],"study_design_scores_gemma":[0.0001506301,0.0001134535,0.0005233386,0.00332058,0.0008819269,0.0002861027,0.00002491534,0.00127455,0.0648439,0.0000112794,0.9278213,0.0007479717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006686272,0.9689059,0.02051969,0.00003972998,0.000430564,0.003231168,0.00001294038,0.00008916469,0.00008455792],"genre_scores_gemma":[0.07565482,0.9196188,0.002563413,0.0000265187,0.0002663921,0.0005889289,0.000008869499,0.0001240185,0.001148218],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9276617,"threshold_uncertainty_score":0.5401509,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2122320166","doi":"10.1093/protein/gzp084","title":"Directed evolution of copper nitrite reductase to a chromogenic reductant","year":2010,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Basic Energy Sciences; National Center for Research Resources; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; U.S. Department of Energy","keywords":"Chromogenic; Chemistry; Alcaligenes faecalis; Substrate (aquarium); Nitrite; Electron acceptor; Nitrite reductase; Combinatorial chemistry; Nitrate reductase; Directed evolution; Biochemistry; Enzyme; Chromatography; Bacteria; Organic chemistry; Biology; Nitrate","retraction":null,"screen_n_in":null,"score":{"opus":0.004411637316303049,"gpt":0.1967959148740751,"spread":0.1923842775577721,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659788,0.00008837293,0.00008533952,0.00008763831,0.00003527071,0.00001048503,0.00003928394,0.00009131836,0.000005361081],"category_scores_gemma":[0.0001710468,0.00008996417,0.000026773,0.0002348016,0.00001328577,0.000005789124,0.00001478697,0.00007206773,0.000001181179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000140984,"about_ca_system_score_gemma":0.00003313377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001462071,"about_ca_topic_score_gemma":0.00000379881,"domain_scores_codex":[0.9994847,0.00002087795,0.0001304564,0.0001927834,0.00006113337,0.0001100094],"domain_scores_gemma":[0.9997147,0.000003515301,0.0000347479,0.00009302212,0.0001006076,0.00005345192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004670791,0.00002469458,0.00004114491,0.00001873717,0.00001697341,9.830442e-8,0.00001797867,0.001605392,0.9976411,0.00006918939,0.0001409022,0.0003771012],"study_design_scores_gemma":[0.0001582312,0.0001965581,0.0005508517,0.00001436524,0.00001254677,0.00001549749,0.000003712934,0.008522611,0.9894186,0.0000110865,0.0009887713,0.0001071521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.861824,0.0002803172,0.1374336,0.0000197463,0.0000576297,0.000344296,0.00000214501,0.00003011919,0.000008116219],"genre_scores_gemma":[0.9850625,0.00001631693,0.01459792,0.000004248342,0.0001004508,0.00007016648,0.0000241107,0.00001526865,0.0001090012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1232385,"threshold_uncertainty_score":0.3668632,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2512802152","doi":"10.1093/protein/gzw043","title":"Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing","year":2016,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph; Wilfrid Laurier University; University of Ottawa; National Research Council Canada","funders":"","keywords":"Epitope; Panning (audio); Phage display; Antibody; Molecular biology; Epitope mapping; Biology; Computational biology; Single-domain antibody; Ectodomain; Receptor; Genetics","retraction":null,"screen_n_in":null,"score":{"opus":0.109595895598213,"gpt":0.2769870438968428,"spread":0.1673911482986297,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003235192,0.0001330313,0.0002571225,0.0002036165,0.00006211995,0.00001503335,0.00003251303,0.0000792287,0.0000129642],"category_scores_gemma":[0.00009915061,0.000100678,0.00005155696,0.0001893828,0.00004630211,0.0001968066,0.00001616952,0.00007924419,5.170948e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029742,"about_ca_system_score_gemma":0.00005104279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007451173,"about_ca_topic_score_gemma":0.000002871027,"domain_scores_codex":[0.9990313,0.00006365724,0.0003210368,0.0001896879,0.0002029057,0.000191396],"domain_scores_gemma":[0.9995514,0.00006837262,0.0001064897,0.00006853745,0.0001453247,0.00005987909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002017752,0.00003145102,0.0009800447,0.0002422279,0.0000359828,0.000002101316,0.0001393392,0.001454498,0.9933574,0.0002013701,0.000002978268,0.003350879],"study_design_scores_gemma":[0.000335445,0.0004022616,0.000990129,0.0003887133,0.00001935951,0.00003990276,0.000009978228,0.154859,0.8427705,0.00006525809,0.00002427922,0.00009519169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.653977,0.0001616346,0.3454035,0.00005353333,0.00003062665,0.0003348286,0.000001955426,0.00002464882,0.00001225373],"genre_scores_gemma":[0.920976,0.0000680212,0.07867649,0.000002927008,0.0001636564,0.00000887291,0.000003389634,0.00001693041,0.00008371119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2669989,"threshold_uncertainty_score":0.4105529,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2139820393","doi":"10.1093/protein/gzp038","title":"Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding","year":2009,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Government of Canada; Alfred P. Sloan Foundation","keywords":"Epitope; Gene isoform; Monoclonal antibody; Chemistry; Scrapie; Prion protein; Cell biology; Protease; Antibody; Molecular mimicry; Conformational change; Peptide; Biochemistry; Biology; Enzyme; Immunology; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.01140575310655998,"gpt":0.2521792929752478,"spread":0.2407735398686879,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726387,0.000138574,0.000129061,0.00008044331,0.00006667105,0.00002467521,0.0000722423,0.0001084375,0.000009731487],"category_scores_gemma":[0.0001038414,0.0001378972,0.00005825073,0.0001251938,0.00001122788,0.00001227913,0.00002105296,0.0001164794,0.000001022245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001574984,"about_ca_system_score_gemma":0.00002498406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005713632,"about_ca_topic_score_gemma":1.953484e-7,"domain_scores_codex":[0.9992827,0.00004722874,0.0001844161,0.0002340549,0.00007188591,0.0001797156],"domain_scores_gemma":[0.9997224,0.0000113005,0.00006673465,0.00009166918,0.00005464408,0.00005324369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066098,0.00005180686,0.00004081779,0.00002500288,0.00002859951,7.789167e-7,0.00001348045,0.0008117046,0.9693272,0.00006873935,0.000009754152,0.0295155],"study_design_scores_gemma":[0.0003403165,0.0005837088,0.00153286,0.00008260508,0.00001410845,0.00002715277,0.000007859036,0.008189792,0.9878809,0.000103132,0.001058398,0.0001791959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7544171,0.003712765,0.2412945,0.00005989747,0.00004318237,0.0004086783,8.667996e-7,0.0000445293,0.00001850368],"genre_scores_gemma":[0.9860054,0.0005388041,0.01325532,0.00002321082,0.00009350779,0.00003425547,0.00001014411,0.00001238063,0.00002703658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2315883,"threshold_uncertainty_score":0.5623285,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2154769581","doi":"10.1093/protein/15.5.413","title":"Enhanced proliferative effects of a baculovirus-produced fusion protein of insulin-like growth factor and α1-proteinase inhibitor and improved anti-elastase activity of the inhibitor with glutamate at position 351","year":2002,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Fusion protein; Proteinase inhibitor; Pancreatic elastase; Proteolysis; Elastase; Biochemistry; Growth factor; Chemistry; Oligopeptide; Molecular biology; Biology; Enzyme; Peptide; Recombinant DNA; Gene; Receptor","retraction":null,"screen_n_in":null,"score":{"opus":0.004300443749999262,"gpt":0.1823949154207139,"spread":0.1780944716707146,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000089823,0.0002059564,0.0002216372,0.00006593919,0.0001047536,0.00001442375,0.00003939599,0.0001287629,0.000002096236],"category_scores_gemma":[0.0001180469,0.0001521719,0.00004050754,0.0001593579,0.00008073166,0.00002515007,0.00007313317,0.0001022669,8.136051e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001949224,"about_ca_system_score_gemma":0.00002320095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003264395,"about_ca_topic_score_gemma":0.000004208562,"domain_scores_codex":[0.9990811,0.0001221154,0.0001963391,0.0003229726,0.000125536,0.0001518825],"domain_scores_gemma":[0.9994535,0.00001656123,0.0002038084,0.0001191551,0.0001387349,0.00006823814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007008688,0.000140291,0.0001494405,0.0007524695,0.00004828182,4.445563e-7,0.0001473164,0.0001207784,0.9971092,0.000008804059,0.0000054754,0.0008166583],"study_design_scores_gemma":[0.001238309,0.00222527,0.001841784,0.0003250183,0.00002731893,0.000009230341,0.00000387402,0.003165347,0.9909778,0.00001226441,0.000004673244,0.0001690976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799531,0.0005323873,0.01740071,0.00001943641,0.0000375479,0.002024672,0.00001465112,0.00001601998,0.00000143878],"genre_scores_gemma":[0.9982374,0.0000863485,0.001342099,0.00000508751,0.00004867938,0.0002261885,0.000003215795,0.00002249279,0.00002850232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828425,"threshold_uncertainty_score":0.6205389,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2108057554","doi":"10.1093/protein/gzh050","title":"Modification of substrate-binding site of glutamyl endopeptidase from Bacillus intermedius","year":2004,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Institute of Genetics; Russian Foundation for Basic Research","keywords":"Substrate specificity; Endopeptidase; Substrate (aquarium); Chemistry; Biochemistry; Microbiology; Stereochemistry; Biology; Enzyme","retraction":null,"screen_n_in":null,"score":{"opus":0.01710460748196551,"gpt":0.2266243282766053,"spread":0.2095197207946398,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281759,0.0001006377,0.0002008338,0.0002020849,0.00002362977,0.000008310903,0.00002007322,0.00006594417,0.00002929206],"category_scores_gemma":[0.0000598672,0.00009788897,0.00005452845,0.0002647416,0.00002480125,0.00008081306,0.00000570263,0.00010556,0.000004946837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005661847,"about_ca_system_score_gemma":0.00003341408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142628,"about_ca_topic_score_gemma":0.000002677614,"domain_scores_codex":[0.9993479,0.00001715495,0.0002493032,0.0001510788,0.0001302265,0.0001043545],"domain_scores_gemma":[0.9996762,0.00001956929,0.0000883279,0.00006924067,0.00008054867,0.00006606698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008570093,0.00006185307,0.0001281377,0.0000988602,0.00004494551,0.000002773799,0.0001808701,0.009371047,0.9888945,0.00008263812,0.000002402839,0.001046237],"study_design_scores_gemma":[0.001046309,0.0002059986,0.001793031,0.0006388684,0.00005229317,0.00001415493,0.00002323875,0.04132515,0.9547336,0.00006641015,0.00001289408,0.00008805007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6876653,0.00005984162,0.3119622,0.00003564073,0.000006615734,0.0002080983,0.000005953598,0.00003943783,0.00001694551],"genre_scores_gemma":[0.9859025,0.00001778201,0.01392387,0.000005120645,0.00003775359,0.00002637584,0.00003580323,0.00001195767,0.00003882718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2982372,"threshold_uncertainty_score":0.3991796,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2306920531","doi":"10.1093/protein/gzw005","title":"Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics","year":2016,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; McGill University","keywords":"Dynamics (music); Materials science; Chemical physics; Psychology; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.004179508521612457,"gpt":0.1769722400044632,"spread":0.1727927314828508,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009958041,0.0001157194,0.00008255169,0.00002448827,0.00005705272,0.00002377347,0.00003071301,0.0001062238,0.000006400081],"category_scores_gemma":[0.00002361255,0.00009569368,0.00002197456,0.00004660249,0.0000228096,0.000008328963,0.00000930904,0.00005035381,9.332029e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001691105,"about_ca_system_score_gemma":0.00001926204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000745761,"about_ca_topic_score_gemma":0.000009773758,"domain_scores_codex":[0.9994087,0.00001869489,0.0001230508,0.0002393784,0.0000700657,0.0001400851],"domain_scores_gemma":[0.9998049,0.000006801898,0.00002789436,0.00006061287,0.00003852607,0.00006133335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009825837,0.00001428437,0.0004375104,0.00001990059,0.0000191153,6.172047e-7,0.00003248917,0.00009126362,0.9943063,0.0003064623,0.000005091034,0.00466871],"study_design_scores_gemma":[0.001451582,0.0005603457,0.003704445,0.00005997367,0.00003304755,0.00003063739,0.00001037382,0.04956291,0.9422125,0.0002556892,0.001721144,0.0003973383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.449845,0.0001589715,0.5496039,0.00013348,0.00002436582,0.0002081512,0.000002735619,0.00001684308,0.000006550748],"genre_scores_gemma":[0.9970906,0.0003004226,0.002161129,0.00001391817,0.00007012449,0.00004130278,0.0000762284,0.00001612327,0.0002301042],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5474428,"threshold_uncertainty_score":0.3902275,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2110358975","doi":"10.1093/protein/gzg133","title":"Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity","year":2003,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Nitrogen and Sulfur Effects on Brassica","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Brookhaven National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Chemistry; Saccharomyces cerevisiae; Oligomer; Biochemistry; Stereochemistry; Enzyme; Dimer; Moiety; Pyrophosphate; Adenosine triphosphate; Yeast","retraction":null,"screen_n_in":null,"score":{"opus":0.008935975907537204,"gpt":0.2197959962001529,"spread":0.2108600202926157,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161444,0.0001159283,0.000197371,0.0001371325,0.00005992334,0.00001419515,0.00002269648,0.00009166246,0.000002861827],"category_scores_gemma":[0.00007039106,0.0001100869,0.00008875621,0.0001611774,0.00002198762,0.00001906181,0.000006352791,0.00003469847,2.35212e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133119,"about_ca_system_score_gemma":0.00002390278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005076463,"about_ca_topic_score_gemma":0.000003084552,"domain_scores_codex":[0.9994367,0.00003161115,0.0001635531,0.0001702834,0.00006926688,0.0001285704],"domain_scores_gemma":[0.9996823,0.00003545209,0.00009812631,0.00005121399,0.00009663142,0.00003629795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005571921,0.00001525412,0.00007458962,0.0002177411,0.0002543789,5.939749e-8,0.00003539181,0.0009669127,0.9963061,0.000240557,0.000004812338,0.001327051],"study_design_scores_gemma":[0.0007390518,0.000405568,0.001713588,0.000009913419,0.0001777385,0.00000978164,0.000007906725,0.07613365,0.9205544,0.00007001554,0.00006831109,0.0001100574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5647724,0.0000609606,0.4347276,0.000005717445,0.00001491573,0.0003971829,0.00001559646,0.000004991316,5.952917e-7],"genre_scores_gemma":[0.9850174,0.000009869176,0.01469899,0.000003373274,0.00003218012,0.0001537353,0.00005496588,0.00001090516,0.00001854241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.420245,"threshold_uncertainty_score":0.4489212,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2168114460","doi":"10.1093/protein/13.3.143","title":"NMR study of the differential contributions of residues of transforming growth factor alpha to association with its receptor","year":2000,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Biotechnology Research Institute; University of Alberta","funders":"","keywords":"Heteronuclear molecule; Receptor; Epitope; TGF alpha; Transforming growth factor; Chemistry; Ligand (biochemistry); Epidermal growth factor receptor; Biophysics; Biochemistry; Stereochemistry; Nuclear magnetic resonance spectroscopy; Biology; Cell biology; Genetics; Antibody","retraction":null,"screen_n_in":null,"score":{"opus":0.01490311613576445,"gpt":0.2623662566639515,"spread":0.247463140528187,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208288,0.00007667466,0.0001960792,0.00008937567,0.00003791536,0.000005074888,0.00004055149,0.00005456751,0.00005313329],"category_scores_gemma":[0.0001691913,0.00005506206,0.0000245946,0.0003662978,0.000008517004,0.00004146442,0.000004395778,0.0001371805,3.934742e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617377,"about_ca_system_score_gemma":0.00008701483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001494395,"about_ca_topic_score_gemma":0.00001430331,"domain_scores_codex":[0.9991763,0.00005821061,0.0001998243,0.0001071445,0.0003260357,0.000132456],"domain_scores_gemma":[0.9995589,0.00004950513,0.0000516618,0.00005764474,0.0002380955,0.0000441399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005018963,0.0002016365,0.005391383,0.000223475,0.0001119474,1.551704e-7,0.001387431,0.0009513764,0.9890388,0.00001979394,0.00001442874,0.002157722],"study_design_scores_gemma":[0.001065152,0.001853462,0.02745695,0.0002354158,0.0000452485,0.000001369972,0.00002722865,0.0014922,0.9677084,0.000003043603,0.00005612493,0.00005539657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719611,0.00004456828,0.02597168,0.0001100469,0.00001498917,0.001855788,0.000009570306,0.00002083673,0.00001145113],"genre_scores_gemma":[0.9991311,0.00001793862,0.000490783,0.000001583764,0.00003085011,0.0001114521,0.000001058039,0.00001204824,0.0002032294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02716999,"threshold_uncertainty_score":0.2245366,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2075068616","doi":"10.1093/protein/gzg091","title":"Precise and efficient cleavage of recombinant fusion proteins using mammalian aspartic proteases","year":2003,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Sembiosys Genetics (Canada)","funders":"","keywords":"Recombinant DNA; Fusion protein; Tobacco etch virus; Biochemistry; Thioredoxin; Escherichia coli; Cleavage (geology); Enteropeptidase; Chemistry; FLAG-tag; Myc-tag; Cystatin; Protein tag; Protease; Proteases; Tandem affinity purification; Peptide; Target peptide; Biology; Affinity chromatography; Enzyme; Cystatin C; Gene","retraction":null,"screen_n_in":null,"score":{"opus":0.02809522144840556,"gpt":0.2580447007734568,"spread":0.2299494793250512,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003747711,0.0001336616,0.0002018364,0.0001444032,0.00009055696,0.00001743188,0.00002136248,0.00006675868,0.00001336433],"category_scores_gemma":[0.0001681728,0.0001108825,0.0000307103,0.0002181333,0.00003760766,0.00003968531,0.00001650269,0.0001547857,0.000001190842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003539624,"about_ca_system_score_gemma":0.00005330381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006824904,"about_ca_topic_score_gemma":7.871456e-7,"domain_scores_codex":[0.9990953,0.00007616297,0.000195707,0.0002078005,0.0001931557,0.00023192],"domain_scores_gemma":[0.9996653,0.00003127069,0.00004518356,0.00006374551,0.00006445227,0.0001300932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003806676,0.0001613495,0.0009346246,0.0007181169,0.00002629391,0.000009334155,0.0001057001,0.001747444,0.9926796,0.0005188639,0.0000102651,0.002707762],"study_design_scores_gemma":[0.0007087843,0.00096149,0.002950834,0.0004044921,0.00003282475,0.0001847808,0.00001220437,0.1670718,0.8270501,0.00006483386,0.0004122684,0.0001455637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226984,0.0005868028,0.0747135,0.00005423521,0.00003387636,0.001836622,5.714751e-7,0.00003712754,0.00003888493],"genre_scores_gemma":[0.9662929,0.00004183309,0.03316965,0.000003516217,0.00002422226,0.0001002192,9.809976e-7,0.00001861318,0.0003480635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1656294,"threshold_uncertainty_score":0.4521659,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2123896403","doi":"10.1093/protein/gzh073","title":"Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors","year":2004,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Biotechnology Research Institute","funders":"National Research Council Canada; Government of Canada; Genomic Health","keywords":"Tetrapeptide; Bivalent (engine); Peptide; Rational design; Chemistry; Thrombin; Combinatorial chemistry; Stereochemistry; Computational biology; Biochemistry; Biology; Genetics; Immunology; Organic chemistry; Platelet","retraction":null,"screen_n_in":null,"score":{"opus":0.009237527391483659,"gpt":0.1990010954184947,"spread":0.1897635680270111,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263217,0.0001408552,0.0001756079,0.00007864357,0.00005090432,0.0000214165,0.00004158583,0.0001041536,0.000002831627],"category_scores_gemma":[0.00007812095,0.000135387,0.00004599051,0.0002213809,0.00002749158,0.00001240897,0.00001661729,0.00006948264,2.176781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002881144,"about_ca_system_score_gemma":0.00004920392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001792753,"about_ca_topic_score_gemma":0.00001177242,"domain_scores_codex":[0.9992,0.00002807767,0.0002685681,0.0002565225,0.0001244256,0.000122399],"domain_scores_gemma":[0.9996833,0.00002640941,0.0001024809,0.00004487678,0.00007727935,0.00006565468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005041679,0.00003962443,0.0005549211,0.00003205549,0.00006014434,2.024685e-7,0.00003609868,0.08959883,0.9091026,0.00004607088,0.000003462428,0.0004755929],"study_design_scores_gemma":[0.0002487196,0.0003953015,0.00107345,0.00010425,0.00002945717,0.00000555839,0.0000184785,0.0102464,0.9874322,0.0002971549,0.000005994626,0.0001430116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6846181,0.0001595624,0.3149642,0.00002745538,0.000007970594,0.0002071595,0.000002174418,0.00001116226,0.000002208573],"genre_scores_gemma":[0.9477515,0.00004862075,0.05205116,0.000005796315,0.0000693476,0.00004045023,0.00001256925,0.0000132469,0.000007312687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2631334,"threshold_uncertainty_score":0.5520924,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2152042341","doi":"10.1093/protein/13.8.593","title":"Characterization of function and activity of domains A, B and C of xylanase C from Fibrobacter succinogenes S85","year":2000,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Guelph","funders":"","keywords":"Fibrobacter succinogenes; Xylanase; Enzyme kinetics; Xylan; Amidohydrolase; Chemistry; Affinity chromatography; Biochemistry; Enzyme; Stereochemistry; Active site; Fermentation","retraction":null,"screen_n_in":null,"score":{"opus":0.004813435366160661,"gpt":0.1758596099821209,"spread":0.1710461746159603,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003892733,0.00007220347,0.0001091796,0.00002648358,0.00002172745,0.000003578099,0.0000122734,0.00005256888,0.000006393084],"category_scores_gemma":[0.000008854869,0.00007016198,0.00001515935,0.00004408653,0.00002335318,0.000006171349,0.000009046444,0.00002230791,2.918821e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001808771,"about_ca_system_score_gemma":0.000005771657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006627492,"about_ca_topic_score_gemma":0.000009120166,"domain_scores_codex":[0.9996711,0.00001915683,0.00009765435,0.0001189855,0.00003699675,0.0000561041],"domain_scores_gemma":[0.9998581,0.000009068462,0.00005028419,0.0000405653,0.00002245114,0.00001949311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241714,0.00002330741,0.001945112,0.00007276099,0.00004130348,5.928079e-8,0.00001963583,0.0001494881,0.9890607,0.000006882556,0.000001092037,0.008437928],"study_design_scores_gemma":[0.0002609377,0.0003470069,0.1419668,0.00002836511,0.00002025713,0.000001794112,0.000004139059,0.001400421,0.8558573,0.0000119052,0.00004351423,0.00005763747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708601,0.0003684991,0.0285794,0.000007249753,0.00001034582,0.0001502849,0.00001639541,0.000004685292,0.000003048193],"genre_scores_gemma":[0.9986882,0.0004525933,0.0007719888,0.000002405425,0.00003593251,0.00001033939,0.00001707003,0.000006815983,0.00001463933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1400217,"threshold_uncertainty_score":0.2861122,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2557427659","doi":"10.1093/protein/gzw060","title":"OUP accepted manuscript","year":2016,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Interface Biologics (Canada)","funders":"Iran National Science Foundation","keywords":"Clostridium perfringens; Immunogenicity; Toxin; Escherichia coli; Biology; Fusion protein; Protein subunit; Microbiology; Recombinant DNA; In vitro; Virology; Bacteria; Gene; Biochemistry; Genetics; Antigen","retraction":null,"screen_n_in":null,"score":{"opus":0.02549404588315969,"gpt":0.252551548040074,"spread":0.2270575021569143,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046576,0.00007852041,0.0001284798,0.00009389935,0.00002849103,0.000008553766,0.00002229047,0.00005326957,0.00008665589],"category_scores_gemma":[0.0002607646,0.00005311759,0.00002361119,0.00007772752,0.00001718902,0.00006929985,0.00001091546,0.00008970349,0.00001798852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000433856,"about_ca_system_score_gemma":0.00001178039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007834218,"about_ca_topic_score_gemma":3.441519e-7,"domain_scores_codex":[0.9993941,0.00003900229,0.0001053646,0.0001468202,0.00007097854,0.0002437499],"domain_scores_gemma":[0.9997776,0.00001184018,0.00001363396,0.00004598185,0.00003321484,0.0001177249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001825835,0.0000153357,0.000745932,0.0000360522,0.00002033348,0.00000703965,0.000005656792,0.00003046507,0.9667381,0.00008256395,0.0006176595,0.03151826],"study_design_scores_gemma":[0.0110439,0.01045283,0.1603941,0.001512487,0.00008946344,0.001794657,0.00001772255,0.1460685,0.6206378,0.0008918276,0.04621293,0.0008837849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1943476,0.0001276553,0.8036928,0.001189453,0.00003473676,0.0004202659,5.080663e-7,0.0001396404,0.00004732323],"genre_scores_gemma":[0.9785085,0.00007925083,0.02019528,0.00005192781,0.0001006687,0.00009271134,0.000001069814,0.00001344585,0.0009571628],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7841609,"threshold_uncertainty_score":0.2166072,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4309745917","doi":"10.1093/protein/gzac015","title":"Integrating dynamics into enzyme engineering","year":2022,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; PROTEO; Institut National de la Recherche Scientifique; Centre in Green Chemistry and Catalysis","funders":"Université de Montréal; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Protein engineering; Dynamics (music); Function (biology); Biochemical engineering; Computer science; Protein dynamics; Molecular dynamics; Enzyme; Engineering; Chemistry; Biology; Biochemistry; Computational chemistry; Cell biology; Physics","retraction":null,"screen_n_in":null,"score":{"opus":0.003104017267763148,"gpt":0.1809196792974258,"spread":0.1778156620296626,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180657,0.0001516474,0.00009895927,0.00008510491,0.0001669707,0.00003043574,0.00008920948,0.00007068815,0.000006682371],"category_scores_gemma":[0.00007332784,0.000169902,0.00003397465,0.0001673839,0.000008532527,0.000006542372,0.00009103245,0.000229412,4.179165e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007750037,"about_ca_system_score_gemma":0.0000304198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002427306,"about_ca_topic_score_gemma":0.000004891765,"domain_scores_codex":[0.999287,0.00003397441,0.0001330927,0.0002482019,0.0001045533,0.000193183],"domain_scores_gemma":[0.9997911,0.000008587085,0.00003612118,0.00008617395,0.00002658498,0.00005140549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003143915,0.000008996506,0.00003848289,0.00002900109,0.00002308049,0.000001339682,0.00004486701,0.1801723,0.8152038,0.001473804,0.00002241708,0.002950448],"study_design_scores_gemma":[0.0002213415,0.0003517299,0.00005758836,0.000009743505,0.000008446718,0.00007128959,0.00002376209,0.8830707,0.112582,0.000171019,0.003180366,0.0002519935],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1480466,0.0004087006,0.8510035,0.00003588552,0.00008773034,0.0003277872,0.000002035777,0.0000714971,0.0000162927],"genre_scores_gemma":[0.9274716,0.00001062992,0.07194225,0.00002411847,0.0001100904,0.0002438099,0.00003596435,0.00003376507,0.0001277711],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.779425,"threshold_uncertainty_score":0.6928403,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}