{"meta":{"page":1,"per_page":50,"max_per_page":100,"total":45,"total_is_capped":false,"direct_labels_cover":0,"predictions_cover":45,"direct_label_status":"direct model label, unvalidated","prediction_status":"machine_predicted_unvalidated (Codex and Gemma teacher distillation)","score_status":"score_only:v0-immature-baseline (scores rank; they never assert a category)","snapshot":{"source":"OpenAlex, pinned release, all 482 partitions","release":"2026-06-24","frame_built":"2026-07-12","author_layer_release":"2026-06-26"},"query_hash":"b9abb93195a7","filters":{"venue":"The Annual Review of Pharmacology and Toxicology"}},"results":[{"id":"W2170355588","doi":"10.1146/annurev.pharmtox.41.1.145","title":"Regulation and Role of Adenylyl Cyclase Isoforms","year":2001,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":683,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Imperial College London; Institut national de la recherche scientifique","keywords":"Adenylyl cyclase; Gene isoform; ADCY9; Mediator; ADCY10; Cell biology; Receptor; Calmodulin; Extracellular; Gs alpha subunit; ADCY3; ADCY6; Biology; Biochemistry; Enzyme; Chemistry; Gene","authors":[{"name":"Jacques Hanoune","is_ca":false},{"name":"Nicole Defer","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05688149880900301,"gpt":0.4203314476669924,"spread":0.3634499488579894,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233945,0.0004903337,0.0006645414,0.0007185412,0.0002003259,0.0005692597,0.0005317719,0.000487716,0.001217601],"category_scores_gemma":[0.0001757481,0.0001778267,0.0002230343,0.0008030419,0.0003047478,0.0005505077,0.0003046275,0.000755248,0.001000875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005760797,"about_ca_system_score_gemma":0.000575153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128315,"about_ca_topic_score_gemma":0.001161263,"domain_scores_codex":[0.9998296,0.00002083542,0.00001997661,0.00005262544,0.0000551278,0.00002165066],"domain_scores_gemma":[0.9999431,0.0000156787,0.00001223917,0.000003054801,0.00001826622,0.000007559711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002210797,0.00005578618,0.0009170081,0.01065359,0.00008554775,0.001178768,0.0002012076,0.0008242073,0.1131377,0.009918045,0.0100135,0.8527936],"study_design_scores_gemma":[0.00003497737,0.0001712503,0.006176986,0.001070736,0.0001216226,0.004088063,0.0001290011,0.0002809103,0.02737671,0.0042069,0.95631,0.00003276542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001806446,0.9948065,0.0004759319,0.0002532808,0.0000947376,0.000005908098,0.00003802339,0.00001303464,0.002506168],"genre_scores_gemma":[0.01341011,0.9834841,0.0005723431,0.0001242861,0.000134349,0.00001173774,0.00009176016,0.000002533012,0.002168777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00128315,"threshold_uncertainty_score":0.004179776,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2158207659","doi":"10.1146/annurev.pharmtox.42.091701.082314","title":"Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function","year":2002,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":577,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"G protein-coupled receptor; Receptor; Biogenesis; Function (biology); Biology; Cell biology; Ligand (biochemistry); Biophysics; Biochemistry; Computational biology; Chemistry; Gene","authors":[{"name":"Stéphane Angers","is_ca":true},{"name":"Ali Salahpour","is_ca":true},{"name":"Michel Bouvier","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02957683725806497,"gpt":0.3497590793519139,"spread":0.3201822420938489,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407312,0.000917019,0.001786326,0.001099007,0.0007816338,0.001783735,0.001751358,0.002361325,0.002654409],"category_scores_gemma":[0.0007809217,0.0003374972,0.0005095782,0.001509151,0.005095589,0.004515797,0.001486797,0.003162378,0.002351523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001651381,"about_ca_system_score_gemma":0.00169191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008152499,"about_ca_topic_score_gemma":0.0004768401,"domain_scores_codex":[0.9994434,0.0001418673,0.00004831498,0.0001275224,0.0001923949,0.00004645591],"domain_scores_gemma":[0.9995608,0.0002061212,0.00004849211,0.00004071421,0.00009170192,0.00005212476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001546941,0.00006055547,0.0003793315,0.007497671,0.00004889366,0.0006771205,0.0005892589,0.0006669032,0.009650977,0.2217252,0.01657055,0.7419788],"study_design_scores_gemma":[0.00002066818,0.0001100696,0.0005557862,0.0007753061,0.00002475947,0.001710445,0.0003126622,0.0002090329,0.001868171,0.06683271,0.9275498,0.00003066111],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008389278,0.9873554,0.002832165,0.002227016,0.0006932219,0.000009737851,0.00001529073,0.00002861559,0.005999542],"genre_scores_gemma":[0.00652002,0.9877604,0.001209707,0.001300334,0.0009112209,0.0000261437,0.00002978501,0.000006249252,0.002236149],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002654409,"threshold_uncertainty_score":0.01198161,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2158321076","doi":"10.1146/annurev.pharmtox.011008.145634","title":"Akt/GSK3 Signaling in the Action of Psychotropic Drugs","year":2008,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":521,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université Laval","funders":"National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"Protein kinase B; Monoamine neurotransmitter; GSK-3; Dopamine receptor D2; Dopamine; Neuroscience; Pharmacology; Signal transduction; Arrestin; Dopamine receptor; Medicine; Serotonin; Receptor; Psychology; G protein-coupled receptor; Biology; Internal medicine; Cell biology","authors":[{"name":"Jean‐Martin Beaulieu","is_ca":true},{"name":"Raul R. Gainetdinov","is_ca":false},{"name":"Marc G. Caron","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03281968591974794,"gpt":0.3833136512447667,"spread":0.3504939653250188,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005549893,0.001502238,0.001714831,0.001966434,0.0004128154,0.001285956,0.001158837,0.001495288,0.003432624],"category_scores_gemma":[0.0003303098,0.0004540929,0.0004517307,0.00194514,0.0005897425,0.001453469,0.0007413357,0.002104023,0.005602147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047536,"about_ca_system_score_gemma":0.0009639453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007143929,"about_ca_topic_score_gemma":0.001723751,"domain_scores_codex":[0.9998275,0.00002474758,0.00002489303,0.00003055676,0.00006858592,0.00002374119],"domain_scores_gemma":[0.9998647,0.00003679777,0.00002264497,0.000004886947,0.00004616522,0.00002488394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000189423,0.00009478184,0.0001603824,0.009577599,0.00009160011,0.0005237592,0.00006412056,0.0006660352,0.005718817,0.00603882,0.03927621,0.9375985],"study_design_scores_gemma":[0.00006558844,0.000113433,0.0007964225,0.001237405,0.00006828827,0.001325314,0.00004942488,0.0001284989,0.001490954,0.003465014,0.9912368,0.00002282226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002608,0.9965643,0.0002007206,0.0003255207,0.0003874748,0.000008443815,0.00002051019,0.00001945157,0.002212749],"genre_scores_gemma":[0.0009434865,0.9969796,0.0002067934,0.000202795,0.0002330524,0.0000105309,0.00003512647,0.000001892216,0.001386769],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003432624,"threshold_uncertainty_score":0.01148331,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2169099940","doi":"10.1146/annurev-pharmtox-061008-103102","title":"Epigenetics, DNA Methylation, and Chromatin Modifying Drugs","year":2008,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":376,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Epigenetics; DNA methylation; Histone; Biology; Epigenetic regulation of neurogenesis; Chromatin; Epigenetic therapy; Cancer epigenetics; Epigenomics; Genetics; Gene; Disease; Chromatin remodeling; Computational biology; Gene expression; Medicine; Histone methyltransferase","authors":[{"name":"Moshe Szyf","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0241262596252624,"gpt":0.3615926628702834,"spread":0.337466403245021,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004288752,0.001150626,0.00118,0.001685745,0.000421554,0.0007219979,0.001089576,0.001289345,0.003887201],"category_scores_gemma":[0.0003821817,0.0002847934,0.0003303322,0.001600435,0.000862951,0.001155651,0.0007095403,0.001649973,0.003937651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008303168,"about_ca_system_score_gemma":0.0006607097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000913659,"about_ca_topic_score_gemma":0.00187385,"domain_scores_codex":[0.9998148,0.00003586411,0.00001478447,0.00003684801,0.00007986984,0.00001781753],"domain_scores_gemma":[0.9998747,0.00004920088,0.0000166074,0.000008547507,0.00003188333,0.0000191781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006554091,0.0001322947,0.0001829019,0.006644576,0.00005627823,0.0004940635,0.00008126657,0.0005750434,0.008927115,0.01405803,0.05404499,0.9147379],"study_design_scores_gemma":[0.00001422831,0.00006585185,0.0003591848,0.0005460274,0.00001966252,0.001356104,0.00002789426,0.00007277071,0.001585089,0.004424162,0.9915174,0.00001158787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001702491,0.9956092,0.0004191646,0.0003455391,0.0003853219,0.000008692503,0.00001456253,0.00001883247,0.003028475],"genre_scores_gemma":[0.001377387,0.9940852,0.0004229515,0.0003477053,0.0003482415,0.00001659106,0.00002753102,0.000002918506,0.003371446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003887201,"threshold_uncertainty_score":0.013004,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2125788813","doi":"10.1146/annurev.pharmtox.44.101802.121424","title":"Developmental Neuropathology of Environmental Agents","year":2004,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":360,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; National Institute on Alcohol Abuse and Alcoholism","keywords":"Neuropathology; Methylmercury; Neurotoxicity; Neuroscience; Central nervous system; Medicine; Nervous system; Physiology; Biology; Pathology; Toxicity; Internal medicine; Disease","authors":[{"name":"Lucio G. Costa","is_ca":false},{"name":"Michael Aschner","is_ca":false},{"name":"Annabella Vitalone","is_ca":false},{"name":"Tore Syversen","is_ca":false},{"name":"Offie P. Soldin","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02703350417766872,"gpt":0.3369310281086833,"spread":0.3098975239310146,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797117,0.0008707125,0.0006842783,0.001563938,0.0003848409,0.0006890564,0.0004949478,0.0006928886,0.003152047],"category_scores_gemma":[0.0002285779,0.0001377187,0.000288779,0.00114921,0.0004153969,0.0005737867,0.0006335111,0.0006611591,0.001573535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653188,"about_ca_system_score_gemma":0.0007372522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002263898,"about_ca_topic_score_gemma":0.00276786,"domain_scores_codex":[0.9998754,0.00002087259,0.00001465787,0.00002352171,0.00004843827,0.00001716317],"domain_scores_gemma":[0.9999025,0.00002116594,0.00002124773,0.000006255519,0.00003978069,0.000009068594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005782801,0.00008815759,0.00123953,0.01057575,0.00009145545,0.00372787,0.0002404434,0.0005231393,0.02433331,0.008770427,0.02353485,0.9268172],"study_design_scores_gemma":[0.000009346209,0.0001558836,0.006406803,0.003119852,0.0001129136,0.02236806,0.0002769905,0.0001402787,0.01377439,0.005566282,0.9480443,0.00002479705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001934968,0.9883777,0.0006142002,0.0002674617,0.000257395,0.00001129421,0.00003695376,0.0000253606,0.008474641],"genre_scores_gemma":[0.007870678,0.9848812,0.0004390573,0.0001670976,0.0001458184,0.00001306423,0.00004535862,0.000002690203,0.006435136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003152047,"threshold_uncertainty_score":0.01054466,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2116004391","doi":"10.1146/annurev-pharmtox-010611-134529","title":"Drug Transporters in Drug Efficacy and Toxicity","year":2011,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":354,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Drug; ATP-binding cassette transporter; Transporter; Pharmacology; Efflux; Biology; Drug metabolism; Efficacy; Drug development; Computational biology; Medicine; Genetics; Gene","authors":[{"name":"M.K. DeGorter","is_ca":true},{"name":"Chenxi Xia","is_ca":false},{"name":"Johnny Yang","is_ca":false},{"name":"R B Kim","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02623551943710283,"gpt":0.3512868675268911,"spread":0.3250513480897883,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007543917,0.001070964,0.002144481,0.001942949,0.0004150148,0.001622444,0.001122958,0.001728553,0.007282352],"category_scores_gemma":[0.0007833697,0.0003347483,0.0005811141,0.002119096,0.0009801297,0.001798573,0.001145345,0.002157795,0.006116931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001161184,"about_ca_system_score_gemma":0.001226454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068275,"about_ca_topic_score_gemma":0.001217748,"domain_scores_codex":[0.9994993,0.000119719,0.00005839614,0.00006865284,0.0002120337,0.00004185489],"domain_scores_gemma":[0.9996376,0.0001357386,0.00005518006,0.0000174678,0.000119379,0.00003461243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001036798,0.00009680978,0.000238865,0.01055002,0.0000806485,0.0005900875,0.0001212577,0.0008179403,0.006349585,0.01778879,0.04236081,0.9209015],"study_design_scores_gemma":[0.00001440913,0.00009702979,0.000467097,0.001040098,0.00004226316,0.001720954,0.00004991856,0.0001778238,0.001397015,0.005187656,0.9897848,0.00002103008],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001983705,0.9957573,0.0004233837,0.0004353035,0.0002449725,0.000007602362,0.00002180078,0.00001743171,0.002893891],"genre_scores_gemma":[0.002483993,0.9929477,0.0003617648,0.0003144213,0.0003652752,0.00001411502,0.0000449676,0.000005338112,0.003462439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007282352,"threshold_uncertainty_score":0.02436185,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2612876306","doi":"10.1146/annurev-pharmtox-010716-104908","title":"Repairing Mitochondrial Dysfunction in Disease","year":2017,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":341,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"National Institute on Aging; Canadian Institutes of Health Research; École Polytechnique Fédérale de Lausanne; Kidney Foundation of Canada; University of Ottawa; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Mitophagy; Mitochondrion; Mitochondrial biogenesis; Biology; Mitochondrial disease; Oxidative phosphorylation; Organelle biogenesis; Biogenesis; Disease; Function (biology); Cell biology; Bioinformatics; Mitochondrial DNA; mitochondrial fusion; Medicine; Genetics; Autophagy; Biochemistry; Gene; Pathology","authors":[{"name":"Vincenzo Sorrentino","is_ca":false},{"name":"Keir J. Menzies","is_ca":true},{"name":"Johan Auwerx","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03965627992621107,"gpt":0.3822775896271417,"spread":0.3426213097009306,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006068769,0.0007721441,0.00105974,0.001937541,0.0004635871,0.001306381,0.0009178875,0.001415561,0.006708047],"category_scores_gemma":[0.0007924379,0.0001778294,0.0003945587,0.001560951,0.0005803099,0.001564889,0.001316607,0.001827599,0.005254308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008121584,"about_ca_system_score_gemma":0.001140887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006784306,"about_ca_topic_score_gemma":0.001254909,"domain_scores_codex":[0.9997713,0.00003966891,0.0000316492,0.00003939234,0.00008954167,0.0000284604],"domain_scores_gemma":[0.9997612,0.00007458223,0.00003567162,0.0000111112,0.00008194326,0.00003546389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005391811,0.00005728725,0.0002067997,0.01133289,0.00006631295,0.0003617326,0.0001055691,0.000195181,0.002484878,0.008520039,0.06908377,0.9075316],"study_design_scores_gemma":[0.000007723174,0.00004055227,0.0003769173,0.002070647,0.00003624209,0.00173218,0.00004792253,0.00004441431,0.0004742594,0.00327202,0.9918851,0.00001203685],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001364929,0.9963832,0.0002963991,0.0005880499,0.0005333979,0.000006507061,0.00003138642,0.0000268422,0.001997646],"genre_scores_gemma":[0.001176739,0.9960764,0.0003000707,0.0003876872,0.0003802006,0.000008721165,0.00006388989,0.000004828012,0.001601398],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006708047,"threshold_uncertainty_score":0.02244067,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2120635383","doi":"10.1146/annurev-pharmtox-011613-135959","title":"Targeting Multidrug Resistance Protein 1 (MRP1, <i>ABCC1</i>): Past, Present, and Future","year":2013,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":314,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"ABCC1; Xenobiotic; Efflux; Context (archaeology); Glutathione; Multidrug Resistance-Associated Proteins; Multiple drug resistance; ATP-binding cassette transporter; Drug metabolism; Biology; Abcg2; Transporter; Pharmacology; Oxidative stress; Chemistry; Biochemistry; Cell biology; Drug; Gene; Enzyme; Antibiotics","authors":[{"name":"Susan P.C. Cole","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01726851769543151,"gpt":0.3374411178287995,"spread":0.320172600133368,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004694088,0.0006331619,0.001062291,0.001497783,0.0002167971,0.0008330092,0.0006228663,0.0009065281,0.002984193],"category_scores_gemma":[0.0004446289,0.0002109416,0.0003405759,0.001769756,0.0004632342,0.001605564,0.0005692065,0.001383542,0.002337001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004910032,"about_ca_system_score_gemma":0.0007608965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005709651,"about_ca_topic_score_gemma":0.001248234,"domain_scores_codex":[0.9998772,0.00002333503,0.00001667552,0.00002369075,0.00004190068,0.00001707823],"domain_scores_gemma":[0.9998137,0.00006202255,0.00003095335,0.000007025459,0.00005935631,0.00002685527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007341334,0.00007263337,0.0001727547,0.01040505,0.00004825256,0.0002154066,0.00005933236,0.0002296142,0.004714394,0.003485486,0.02260373,0.9579199],"study_design_scores_gemma":[0.00002383748,0.0001677419,0.0007225288,0.001359969,0.00007483538,0.00182578,0.00005584657,0.0001105882,0.001173905,0.001845974,0.9926207,0.00001819181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002113026,0.9982656,0.0001530363,0.0003651957,0.0001400816,0.000002963217,0.00001085653,0.00000954679,0.0008414423],"genre_scores_gemma":[0.0008343339,0.9980739,0.0002050588,0.0001885846,0.0001596405,0.000005561608,0.00002133569,0.000001724132,0.0005097078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002984193,"threshold_uncertainty_score":0.009983122,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2161643992","doi":"10.1146/annurev.pharmtox.47.120505.105150","title":"Idiosyncratic Drug Reactions: Current Understanding","year":2006,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":299,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"Idiosyncrasy; Circumstantial evidence; Drug; Mechanism (biology); Biology; Computational biology; Pharmacology; Epistemology","authors":[{"name":"Jack Uetrecht","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.2218572512858677,"gpt":0.4982578173616561,"spread":0.2764005660757884,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002038613,0.001722726,0.003447472,0.002980027,0.0004666879,0.002646474,0.001967104,0.00283523,0.006163852],"category_scores_gemma":[0.0020564,0.0005559374,0.0009042463,0.00327821,0.001764807,0.004431636,0.001330568,0.003240501,0.004165999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077974,"about_ca_system_score_gemma":0.002097567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001601807,"about_ca_topic_score_gemma":0.001964702,"domain_scores_codex":[0.9992981,0.0001216241,0.0001497417,0.0001416221,0.0002395351,0.00004934378],"domain_scores_gemma":[0.9975133,0.001354563,0.0004311141,0.00009586368,0.0004182345,0.0001870523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008201172,0.00006126651,0.000480562,0.01378458,0.00008081929,0.0003642382,0.00009774137,0.0004022812,0.0004157367,0.003752195,0.02602863,0.9544498],"study_design_scores_gemma":[0.00004412764,0.0001646735,0.002429611,0.013591,0.0002929821,0.006988182,0.0003425335,0.0003452708,0.0003803866,0.01289051,0.9624779,0.00005287772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006996663,0.9983052,0.0001744425,0.0006277019,0.0001020479,0.00000340406,0.0000131483,0.00001058228,0.0006934552],"genre_scores_gemma":[0.0005763117,0.9983369,0.0001628634,0.0002959077,0.0003560896,0.000005223966,0.00002287129,0.000001199276,0.0002426786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006163852,"threshold_uncertainty_score":0.02062017,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2028513366","doi":"10.1146/annurev.pharmtox.47.120505.105230","title":"Intracellular Targets of Matrix Metalloproteinase-2 in Cardiac Disease: Rationale and Therapeutic Approaches","year":2006,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":293,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Matrix metalloproteinase; Oxidative stress; Proteolysis; Extracellular matrix; Tissue inhibitor of metalloproteinase; Intracellular; Metalloproteinase; Endogeny; Pharmacology; Medicine; Matrix metalloproteinase inhibitor; Cell biology; Chemistry; Extracellular; Cancer research; Biology; Enzyme; Internal medicine; Biochemistry","authors":[{"name":"Richard Schulz","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02609425346194741,"gpt":0.3215484745386142,"spread":0.2954542210766669,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009389239,0.001122493,0.001592577,0.001844066,0.0003152619,0.001166553,0.001558095,0.00173799,0.002401506],"category_scores_gemma":[0.0005449295,0.0003320324,0.0004047818,0.001267607,0.00101832,0.001601836,0.0007722485,0.002723126,0.002577206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007432682,"about_ca_system_score_gemma":0.0008847117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003550622,"about_ca_topic_score_gemma":0.0006684287,"domain_scores_codex":[0.9997982,0.00004762222,0.00002705998,0.00003637961,0.00007121547,0.00001948132],"domain_scores_gemma":[0.9997759,0.00009219971,0.00002923688,0.00001288739,0.00006297123,0.00002685448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001794738,0.000280344,0.0002055001,0.00921687,0.00006893041,0.0009828965,0.0001085647,0.0006950076,0.009492814,0.020117,0.03609253,0.92256],"study_design_scores_gemma":[0.00008419262,0.0002982216,0.0005737505,0.002611089,0.00008742024,0.004246649,0.00008138956,0.0002553626,0.002250228,0.009722879,0.9797563,0.00003250735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001521798,0.9975318,0.0004608044,0.0006661068,0.0002809828,0.000007534471,0.000008928329,0.00001014183,0.0008815371],"genre_scores_gemma":[0.001117767,0.99661,0.0007488519,0.0003534016,0.0003751089,0.00002195718,0.00001965925,0.000002158091,0.0007509871],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002401506,"threshold_uncertainty_score":0.008033812,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2143544378","doi":"10.1146/annurev-pharmtox-061008-103038","title":"The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes","year":2008,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University; Université de Montréal; Dalhousie University","funders":"National Institutes of Health","keywords":"Effector; G protein-coupled receptor; Cell biology; Signal transduction; Receptor; Cell signaling; G protein; Protein subunit; Biology; Chemistry; Function (biology); Biochemistry; Gene","authors":[{"name":"Denis J. Dupré","is_ca":true},{"name":"Mélanie Robitaille","is_ca":true},{"name":"R. Victor Rebois","is_ca":false},{"name":"Terence E. Hébert","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01593686437129242,"gpt":0.3121301754907215,"spread":0.296193311119429,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005372551,0.0008566231,0.001275881,0.00128502,0.0003323704,0.0009423978,0.0009307195,0.001169985,0.002002324],"category_scores_gemma":[0.0003554273,0.000318285,0.000290328,0.001687688,0.0008087811,0.001462502,0.0006456132,0.001509804,0.00407513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009577236,"about_ca_system_score_gemma":0.001142572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032778,"about_ca_topic_score_gemma":0.001144079,"domain_scores_codex":[0.999858,0.00002112221,0.00001712215,0.00003116705,0.00005225764,0.00002033639],"domain_scores_gemma":[0.9998536,0.00004529399,0.00002501768,0.00000800057,0.00004117149,0.0000268774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008559549,0.00004757936,0.0002249968,0.007829619,0.00004462422,0.0003570372,0.00007994371,0.0006089144,0.008232781,0.009474796,0.01856614,0.954448],"study_design_scores_gemma":[0.00001881893,0.00007749512,0.001075991,0.001220321,0.00005089151,0.001322077,0.00007636639,0.00009141168,0.00158595,0.005287784,0.9891732,0.00001958971],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002867161,0.9971665,0.0003762224,0.0003331717,0.0001803219,0.000005162139,0.00001415194,0.0000141745,0.001623693],"genre_scores_gemma":[0.0008967852,0.9978232,0.000253485,0.0001506333,0.0001300379,0.000005722662,0.00002211272,0.000001394463,0.0007166425],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002002324,"threshold_uncertainty_score":0.006948829,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2145315186","doi":"10.1146/annurev.pharmtox.42.091601.142813","title":"Glycopeptide Antibiotic Resistance","year":2002,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McMaster University","funders":"","keywords":"Glycopeptide; Antibiotics; Antibiotic resistance; Microbiology; Virulence; Biology; Bacteria; Glycopeptide antibiotic; Gene; Computational biology; Vancomycin; Staphylococcus aureus; Genetics","authors":[{"name":"Jeff Pootoolal","is_ca":true},{"name":"John M. Neu","is_ca":true},{"name":"Gerard D. Wright","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03333524559854153,"gpt":0.3797161555212049,"spread":0.3463809099226634,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638215,0.0008300676,0.0009944452,0.001155299,0.0002849151,0.0008082722,0.0005553632,0.0007982235,0.0033847],"category_scores_gemma":[0.0003496797,0.0001120048,0.0002475492,0.001004183,0.00038318,0.0005429625,0.0004044971,0.0008313749,0.004701443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336021,"about_ca_system_score_gemma":0.0005920113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005130121,"about_ca_topic_score_gemma":0.0006488999,"domain_scores_codex":[0.99978,0.00003247995,0.00001924543,0.0000370286,0.0001101275,0.00002116973],"domain_scores_gemma":[0.9998697,0.0000308776,0.00002563972,0.000008576337,0.00004656548,0.00001864495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005130809,0.00008329619,0.0003210419,0.004188125,0.00002718349,0.0006118646,0.00006646539,0.00018025,0.01492772,0.003354783,0.02395331,0.9522346],"study_design_scores_gemma":[0.00001507347,0.0001588299,0.001415804,0.0009299075,0.00003780233,0.005941603,0.00006827189,0.0001154906,0.006544851,0.002098044,0.9826617,0.00001260127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009273736,0.9888133,0.0009349296,0.0004938314,0.0004081549,0.00001708758,0.00003617864,0.00003762917,0.008331385],"genre_scores_gemma":[0.006112449,0.9849525,0.0008625102,0.0003869637,0.0002624391,0.00001932268,0.00007665559,0.000004445703,0.007322634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0033847,"threshold_uncertainty_score":0.01132298,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2139898757","doi":"10.1146/annurev-pharmtox-061008-103222","title":"Progress in Genetic Studies of Pain and Analgesia","year":2008,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke","keywords":"Mediation; Analgesic; Field (mathematics); Neuroscience; Psychology; Medicine; Anesthesia; Sociology; Social science","authors":[{"name":"Michael L. LaCroix‐Fralish","is_ca":true},{"name":"Jeffrey S. Mogil","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05071187144245431,"gpt":0.4315052009251744,"spread":0.38079332948272,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002177069,0.0009386493,0.001630855,0.001814168,0.0003987118,0.001278049,0.001142857,0.001394936,0.002605319],"category_scores_gemma":[0.001527611,0.0002750708,0.0006731279,0.001864104,0.001684238,0.001522154,0.0009791674,0.002319409,0.001139472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101913,"about_ca_system_score_gemma":0.0022933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002004703,"about_ca_topic_score_gemma":0.001520501,"domain_scores_codex":[0.9993836,0.0001780342,0.00005361085,0.0001554617,0.0001821401,0.00004719042],"domain_scores_gemma":[0.9988549,0.0006930084,0.0001024992,0.00007689302,0.0002069529,0.00006574306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001405886,0.0001216955,0.001917191,0.01077971,0.0002104132,0.0009483825,0.0002875694,0.000788853,0.01820268,0.0379208,0.01195161,0.9167305],"study_design_scores_gemma":[0.00004796677,0.0002443089,0.006721803,0.003660015,0.0003000335,0.005309813,0.0002708494,0.0003202065,0.006712195,0.03197513,0.944346,0.00009161262],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001141226,0.9886037,0.003798032,0.002129037,0.0004175479,0.0000141412,0.00005844554,0.00003619855,0.003801615],"genre_scores_gemma":[0.003844927,0.9922201,0.002265747,0.0005562763,0.0003590203,0.00001886565,0.00007991932,0.000006818968,0.000648255],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002605319,"threshold_uncertainty_score":0.01151359,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2135812015","doi":"10.1146/annurev.pharmtox.48.113006.094731","title":"Epigenetics and Complex Disease: From Etiology to New Therapeutics","year":2007,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Epigenetics; Disease; Bioinformatics; Epigenesis; Medicine; Epigenetic therapy; Computational biology; Biology; Neuroscience; DNA methylation; Genetics; Pathology; Gene","authors":[{"name":"Carolyn Ptak","is_ca":true},{"name":"Artūras Petronis","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.07071725108616163,"gpt":0.4270927138479714,"spread":0.3563754627618098,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006411814,0.0008446259,0.001238903,0.001470342,0.0003924239,0.001087303,0.000857365,0.001632678,0.003558923],"category_scores_gemma":[0.0005776816,0.000223015,0.0003080578,0.001425342,0.001622087,0.002051444,0.0008397019,0.001904334,0.002183508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001114925,"about_ca_system_score_gemma":0.001107097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008999132,"about_ca_topic_score_gemma":0.001947435,"domain_scores_codex":[0.9997841,0.00006196147,0.00001867666,0.00003194867,0.00008779726,0.00001550756],"domain_scores_gemma":[0.9997535,0.0001345351,0.00002083862,0.00001046193,0.00005151327,0.00002910958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005815502,0.00006605046,0.0002812307,0.005694976,0.00005918117,0.0006371255,0.0002029654,0.0005803626,0.002864406,0.0269503,0.06230165,0.9003035],"study_design_scores_gemma":[0.0000171308,0.00006712091,0.0006079138,0.00173574,0.00002874689,0.002718857,0.0001661675,0.0001506055,0.0005789317,0.01869796,0.9752095,0.00002135933],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009593814,0.9962319,0.0004405428,0.001329349,0.0004436591,0.000002823818,0.00000457092,0.000009236859,0.00144202],"genre_scores_gemma":[0.0007290788,0.9967899,0.000370791,0.0005047213,0.0005091441,0.000005191207,0.000007140491,0.000001784202,0.001082219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003558923,"threshold_uncertainty_score":0.01190585,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4317567454","doi":"10.1146/annurev-pharmtox-051421-112259","title":"Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem","year":2023,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Krembil Foundation; University of Toronto","keywords":"Chronic pain; Neuropathic pain; Analgesic; Medicine; Neuroscience; Bioinformatics; Psychology; Biology; Pharmacology","authors":[{"name":"Shahrzad Ghazisaeidi","is_ca":true},{"name":"Milind M. Muley","is_ca":true},{"name":"Michael W. Salter","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04410784600803687,"gpt":0.3781916816423661,"spread":0.3340838356343292,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005109741,0.0007016212,0.001259205,0.001459368,0.000348441,0.0009474177,0.0008118852,0.001111924,0.006889181],"category_scores_gemma":[0.0006267874,0.0001859653,0.0005400214,0.0010259,0.0005671979,0.001312633,0.0007061673,0.002181976,0.002671598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672082,"about_ca_system_score_gemma":0.0009699969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007522706,"about_ca_topic_score_gemma":0.001801038,"domain_scores_codex":[0.9998286,0.00003897795,0.00002116014,0.00002864704,0.00006065561,0.00002193378],"domain_scores_gemma":[0.9997793,0.000104975,0.00002702704,0.000008404956,0.00005396068,0.000026358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001050845,0.0001014447,0.0001650228,0.01874046,0.00008636155,0.0002573667,0.00008852583,0.0002128882,0.002025852,0.007583031,0.03584041,0.9347937],"study_design_scores_gemma":[0.00001827679,0.0001548983,0.000739786,0.004940058,0.00009697585,0.00152075,0.0000951576,0.00005818893,0.0003438868,0.004393477,0.9876217,0.00001684277],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009016038,0.9982265,0.00009318833,0.0004928537,0.0002465552,0.000003778777,0.00001607826,0.000007124275,0.0008236871],"genre_scores_gemma":[0.0005514235,0.9981108,0.0001087833,0.0003462016,0.0002147133,0.000005161935,0.00002006629,0.000001453707,0.0006415047],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006889181,"threshold_uncertainty_score":0.02304667,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2169188579","doi":"10.1146/annurev.pharmtox.45.120403.095950","title":"NATURAL HEALTH PRODUCTS AND DRUG DISPOSITION","year":2004,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Complementary and Alternative Medicine Studies","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Manitoba; University of Ottawa; Health Canada","funders":"Health Canada; Ontario HIV Treatment Network","keywords":"Medicine; Cosmetics; Confounding; Drug; Population; Nutraceutical; Intensive care medicine; Pharmacology; Environmental health; Pathology","authors":[{"name":"Brian C. Foster","is_ca":true},{"name":"John T. Arnason","is_ca":true},{"name":"Colin J. Briggs","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03782643972486664,"gpt":0.4395621763701658,"spread":0.4017357366452992,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007478558,0.0004992761,0.001254141,0.001392463,0.0002258139,0.001106835,0.0005399501,0.0008843585,0.007862916],"category_scores_gemma":[0.001229032,0.000205001,0.0006159786,0.001860183,0.0004582078,0.0007535578,0.0004234976,0.0007516451,0.002103287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005295605,"about_ca_system_score_gemma":0.0008811073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119141,"about_ca_topic_score_gemma":0.001630058,"domain_scores_codex":[0.9995707,0.0001231476,0.00006301099,0.00007385878,0.0001454389,0.00002382442],"domain_scores_gemma":[0.9994518,0.000258022,0.000162271,0.00002149887,0.00008403706,0.00002239571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003985264,0.0001874666,0.004830108,0.01764942,0.0003936688,0.000910338,0.00009958155,0.0004103262,0.002828169,0.004194478,0.01639473,0.9517031],"study_design_scores_gemma":[0.0002441611,0.001219754,0.03391154,0.007573913,0.0008950285,0.01316027,0.0002582869,0.0004200851,0.005039341,0.007789773,0.9294208,0.00006708522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009850872,0.9959558,0.0001224725,0.0002548858,0.00006484516,0.00001010563,0.00004565691,0.000007266799,0.002553956],"genre_scores_gemma":[0.009928907,0.9874752,0.0001773601,0.0002173992,0.0001171035,0.00002105668,0.00006616255,0.000001555199,0.001995233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007862916,"threshold_uncertainty_score":0.02630413,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2541674337","doi":"10.1146/annurev-pharmtox-010716-104651","title":"GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer","year":2016,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"GPER; Biology; Estrogen receptor; Receptor; Cell growth; Signal transduction; Cancer research; Cell biology; Endocrinology; Cancer; Breast cancer; Biochemistry","authors":[{"name":"Ross D. Feldman","is_ca":true},{"name":"Lee E. Limbird","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01729970855016464,"gpt":0.3440624785020359,"spread":0.3267627699518712,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238258,0.0006688256,0.0009457235,0.001318767,0.0002410201,0.0007151368,0.0005886716,0.0008924094,0.004302295],"category_scores_gemma":[0.0002848942,0.000165728,0.0003572914,0.001452518,0.000347361,0.0009812139,0.0005914349,0.001318382,0.00370537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004381243,"about_ca_system_score_gemma":0.0008206383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303423,"about_ca_topic_score_gemma":0.0008835117,"domain_scores_codex":[0.9999067,0.00001298692,0.00001094811,0.00002062114,0.00003452271,0.00001416812],"domain_scores_gemma":[0.9999213,0.00002560675,0.0000128831,0.0000029664,0.00002374165,0.00001345212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007423188,0.00004447306,0.0002532399,0.009049296,0.0000571453,0.0003525914,0.00007334468,0.000316201,0.00718523,0.006922064,0.05594999,0.9197222],"study_design_scores_gemma":[0.000006695528,0.00004535434,0.0005003713,0.0005422523,0.00003294526,0.001287716,0.00003660489,0.0000430025,0.0004156012,0.001086771,0.9959926,0.00001021472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004691502,0.9937668,0.0004417178,0.0007249314,0.0004604037,0.00001005713,0.00007391811,0.00003712578,0.004015835],"genre_scores_gemma":[0.001495639,0.995261,0.0003028763,0.0004027233,0.0002110563,0.00001003347,0.0001102879,0.000003493293,0.002202792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004302295,"threshold_uncertainty_score":0.01439261,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2098663242","doi":"10.1146/annurev-pharmtox-010814-124414","title":"Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases","year":2014,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Caspase; Proteases; Huntington's disease; Apoptosis; Huntingtin; NLRP1; Neurodegeneration; Alzheimer's disease; Effector; Neuroscience; Biology; Disease; Inflammation; Cell biology; Caspase 2; Programmed cell death; Medicine; Immunology; Pathology; Genetics; Biochemistry; Enzyme","authors":[{"name":"Xiaojun Wang","is_ca":false},{"name":"Qin Cao","is_ca":false},{"name":"Yan Zhang","is_ca":false},{"name":"Xiao‐Dong Su","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01790079906364407,"gpt":0.3390483165959459,"spread":0.3211475175323019,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003612188,0.0007830492,0.001063646,0.001707381,0.0002879916,0.0007878011,0.000797757,0.0008755612,0.002636499],"category_scores_gemma":[0.0003370807,0.0002326046,0.0003589742,0.001769781,0.0004794115,0.0009902928,0.0006855198,0.001517071,0.002221294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006727355,"about_ca_system_score_gemma":0.0008589166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006272189,"about_ca_topic_score_gemma":0.0008900487,"domain_scores_codex":[0.9998305,0.00002597296,0.000024549,0.00002862235,0.00006984209,0.00002048495],"domain_scores_gemma":[0.9998879,0.0000317849,0.00001924196,0.000004493472,0.00004039819,0.00001622476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001043947,0.00009625985,0.0002104711,0.0185914,0.00007864417,0.0004382909,0.0001160901,0.000425624,0.008844019,0.006822742,0.02628627,0.9379858],"study_design_scores_gemma":[0.00002166788,0.0001089969,0.0009620516,0.001682167,0.00005643777,0.002115599,0.00005543048,0.00006886885,0.001451653,0.002827566,0.9906312,0.00001838263],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000154816,0.9984511,0.0001237946,0.0001406117,0.0001588789,0.000004124174,0.00001127002,0.000006776942,0.0009485777],"genre_scores_gemma":[0.0007563751,0.9983636,0.0001209956,0.00008043601,0.0001196531,0.000005367981,0.00001979024,9.638477e-7,0.0005328435],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002636499,"threshold_uncertainty_score":0.008819938,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2157579438","doi":"10.1146/annurev.pharmtox.40.1.43","title":"Chlorinated Methanes and Liver Injury: Highlights of the Past 50 Years","year":2000,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":82,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal","funders":"","keywords":"Carbon tetrachloride; Hexobarbital; Steatosis; Liver injury; Biotransformation; Adverse Outcome Pathway; Lipid peroxidation; Cirrhosis; Chemistry; Endoplasmic reticulum; Long-term potentiation; Biochemistry; Pharmacology; Medicine; Microsome; Biology; Internal medicine; Organic chemistry; Oxidative stress; In vitro; Enzyme","authors":[{"name":"Gàbriel L. Plaa","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0860602427475752,"gpt":0.434710911253724,"spread":0.3486506685061488,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006717425,0.0009747433,0.001210096,0.001945045,0.0003907977,0.001311166,0.0008439842,0.001026929,0.004696219],"category_scores_gemma":[0.0005707513,0.0002707173,0.0004098225,0.004152977,0.0004303985,0.002254463,0.0007476492,0.000985596,0.002210214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008331791,"about_ca_system_score_gemma":0.0009454681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002105426,"about_ca_topic_score_gemma":0.00396935,"domain_scores_codex":[0.9998052,0.0000299743,0.00002831595,0.00003955133,0.00007332407,0.00002366908],"domain_scores_gemma":[0.9995918,0.0001384848,0.00007156837,0.00001257238,0.0001279307,0.00005761099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002703273,0.0001619439,0.0007423187,0.01754602,0.0001037717,0.0006546355,0.0001524413,0.0006565587,0.003608178,0.003272716,0.04231162,0.9305194],"study_design_scores_gemma":[0.00002033173,0.0002597212,0.003191486,0.003364274,0.0001423078,0.002088419,0.0002207846,0.000152346,0.0008923633,0.002533487,0.9871088,0.00002563359],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001872081,0.9986178,0.00003990345,0.0001971845,0.0002187205,0.000001445907,0.000007474818,0.000003181882,0.0007271759],"genre_scores_gemma":[0.0007572455,0.9978119,0.00008929036,0.0001617497,0.0003960402,0.000002570683,0.00001488493,8.402007e-7,0.000765476],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004696219,"threshold_uncertainty_score":0.01571041,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2290120395","doi":"10.1146/annurev-pharmtox-010716-104944","title":"PCSK9: Regulation and Target for Drug Development for Dyslipidemia","year":2016,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"PCSK9; Kexin; Proprotein convertase; LDL receptor; Subtilisin; Proprotein Convertases; Drug development; Drug; Dyslipidemia; Pharmacology; Drug discovery; Receptor; Biology; Bioinformatics; Cholesterol; Medicine; Lipoprotein; Endocrinology; Internal medicine; Biochemistry; Disease; Enzyme","authors":[{"name":"Amy C. Burke","is_ca":true},{"name":"Jacqueline S. Dron","is_ca":true},{"name":"Robert A. Hegele","is_ca":true},{"name":"Murray W. Huff","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03188942251251271,"gpt":0.3901929907340813,"spread":0.3583035682215686,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004602094,0.0007178666,0.001018296,0.001808033,0.0002619767,0.0008739916,0.0007086584,0.001065172,0.005073708],"category_scores_gemma":[0.0005960618,0.0002294275,0.0005384973,0.00145537,0.0004092761,0.001161722,0.0006727746,0.002080464,0.003793471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902582,"about_ca_system_score_gemma":0.0009508839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006402062,"about_ca_topic_score_gemma":0.001258403,"domain_scores_codex":[0.9998216,0.00002677977,0.00002559514,0.00003294327,0.0000726111,0.00002044784],"domain_scores_gemma":[0.999785,0.00007694503,0.00002953276,0.00001092441,0.00006936219,0.00002815728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008759186,0.0000820289,0.0001655953,0.009582104,0.00008200809,0.0002467269,0.0000458218,0.0003149662,0.003307537,0.006040068,0.04867803,0.9313675],"study_design_scores_gemma":[0.0000186642,0.00007539245,0.0004087932,0.001232161,0.00005358008,0.000893957,0.00002245292,0.00008200195,0.0006434977,0.00178626,0.9947707,0.00001249491],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001681228,0.9970493,0.0002513123,0.0005069325,0.0004455473,0.00000611561,0.00003061298,0.00001743467,0.001524755],"genre_scores_gemma":[0.0009749733,0.9964989,0.0003354976,0.0003526943,0.0002425036,0.000007782645,0.00005290664,0.000003427139,0.001531128],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005073708,"threshold_uncertainty_score":0.0169732,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4295754725","doi":"10.1146/annurev-pharmtox-051921-020936","title":"The Duality of Arsenic Metabolism: Impact on Human Health","year":2022,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":78,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Arsenic; Detoxification (alternative medicine); Metabolism; Methylation; Arsenic poisoning; Mechanism (biology); Toxicity; Chemistry; Human health; Arsenic toxicity; Biotransformation; Environmental chemistry; Toxicology; Biology; Biochemistry; Environmental health; Medicine; Enzyme; Organic chemistry; Pathology; Philosophy; Gene","authors":[{"name":"Mahmoud A. El‐Ghiaty","is_ca":true},{"name":"Ayman O.S. El‐Kadi","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05228215112568637,"gpt":0.4445985035257011,"spread":0.3923163524000148,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003033723,0.0005660621,0.0007567032,0.001192583,0.0002787707,0.001214228,0.0004763866,0.000928495,0.004483938],"category_scores_gemma":[0.0003189161,0.0001519287,0.0003005404,0.00162457,0.0004832697,0.001347834,0.0008067887,0.001249082,0.002360486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495372,"about_ca_system_score_gemma":0.001167535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009160807,"about_ca_topic_score_gemma":0.001350018,"domain_scores_codex":[0.9998627,0.00003149455,0.00001337716,0.00002806992,0.0000474789,0.00001691775],"domain_scores_gemma":[0.9998881,0.00004068089,0.00001286241,0.000005073836,0.00003939492,0.00001379887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008952092,0.00005605811,0.0002769979,0.02061113,0.00009794049,0.0003840758,0.0002213945,0.0003493518,0.009688437,0.02325947,0.03857474,0.9063909],"study_design_scores_gemma":[0.000004116281,0.00005376603,0.000400372,0.001192961,0.000034444,0.0007336857,0.00009079643,0.00004143803,0.0006666214,0.004678188,0.992093,0.00001056745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002178156,0.9955183,0.0002586399,0.0007691535,0.0002982543,0.000002434226,0.0000296982,0.00001026441,0.00289541],"genre_scores_gemma":[0.001440844,0.9968758,0.0001575255,0.0002578948,0.0002129913,0.000003061622,0.00002927423,0.000001841101,0.001020729],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004483938,"threshold_uncertainty_score":0.01500028,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2121207675","doi":"10.1146/annurev-pharmtox-010715-103246","title":"Biobanking Comes of Age: The Transition to Biospecimen Science","year":2015,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Kensington Health; Positive Living Society of British Columbia","funders":"","keywords":"Biobank; Translational research; Data science; Personalized medicine; Best practice; Sustainability; Engineering ethics; Data sharing; Knowledge management; Computer science; Medicine; Political science; Bioinformatics; Engineering; Alternative medicine; Biology; Pathology","authors":[{"name":"Jim Vaught","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3726773534890724,"gpt":0.6263749952158223,"spread":0.2536976417267499,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007974539,0.0007224339,0.001797887,0.003127384,0.0009394505,0.004636067,0.00142141,0.003457831,0.003972807],"category_scores_gemma":[0.01106114,0.0004151278,0.0007276367,0.004179534,0.003661481,0.007153707,0.002319516,0.005708253,0.001797089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002748737,"about_ca_system_score_gemma":0.007254916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002222161,"about_ca_topic_score_gemma":0.003324919,"domain_scores_codex":[0.9967506,0.00143135,0.0003958712,0.0002435135,0.000995346,0.0001832661],"domain_scores_gemma":[0.9888545,0.00816017,0.0007570718,0.0002580413,0.001546946,0.0004233075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005048907,0.00005300098,0.0003916791,0.01986788,0.00006400495,0.000388227,0.0006745501,0.0001848082,0.0003288965,0.04653283,0.05288024,0.8785833],"study_design_scores_gemma":[0.000005423947,0.00002927336,0.0005154578,0.01214257,0.00003169222,0.001110684,0.0004263477,0.00003011935,0.0001195672,0.01107946,0.9744945,0.00001500671],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007005261,0.9947346,0.0001756004,0.003606708,0.000457666,0.000003856305,0.000006453478,0.00000466831,0.0009402929],"genre_scores_gemma":[0.0008729071,0.9965187,0.0002427525,0.001533618,0.0005021267,0.000006567689,0.0000114587,0.000003362823,0.0003085632],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007974539,"threshold_uncertainty_score":0.04217386,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3200889336","doi":"10.1146/annurev-pharmtox-021821-091747","title":"Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease","year":2021,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Metabotropic glutamate receptor 5; Metabotropic glutamate receptor; Neuroscience; Synaptic plasticity; Metabotropic glutamate receptor 1; Neurotransmission; Glutamate receptor; Biology; Signal transduction; Cell biology; Receptor; Biochemistry","authors":[{"name":"Khaled S. Abd‐Elrahman","is_ca":true},{"name":"Stephen S. G. Ferguson","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.09547638140641454,"gpt":0.4433761803351329,"spread":0.3478997989287184,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004371566,0.0008242665,0.0009673923,0.001602867,0.0002552927,0.0008096417,0.000821051,0.0009765569,0.004788652],"category_scores_gemma":[0.0003375253,0.0002428952,0.0003284395,0.001522222,0.0003540183,0.001122386,0.0006955721,0.001540621,0.004524727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006123784,"about_ca_system_score_gemma":0.000953241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009311714,"about_ca_topic_score_gemma":0.00196811,"domain_scores_codex":[0.9999057,0.00001482466,0.00001414589,0.00001666388,0.00003640983,0.00001223752],"domain_scores_gemma":[0.999882,0.0000331964,0.00001852883,0.00000412381,0.00004108942,0.00002109524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008071948,0.00005859349,0.0001127985,0.01103356,0.00005075285,0.0002291734,0.0000474083,0.0002366837,0.002144706,0.004344205,0.04548453,0.9361768],"study_design_scores_gemma":[0.00001610438,0.00007359215,0.0005038623,0.001806919,0.00004641514,0.0009351771,0.00002589509,0.00004751058,0.0002674427,0.001636608,0.9946294,0.00001105534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009098405,0.998274,0.00006454222,0.0002478627,0.000248894,0.000003235459,0.00001323784,0.000008467567,0.001048841],"genre_scores_gemma":[0.0003996061,0.9983765,0.00008199671,0.0001608064,0.0001873331,0.000004016038,0.00002281537,0.000001143147,0.0007657127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004788652,"threshold_uncertainty_score":0.0160197,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2159215032","doi":"10.1146/annurev-pharmtox-011112-140343","title":"Unnatural Amino Acids as Probes of Ligand-Receptor Interactions and Their Conformational Consequences","year":2013,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Amino acid; Chemistry; Ligand (biochemistry); Stereochemistry; Receptor; Biophysics; Biochemistry; Biology","authors":[{"name":"Stephan A. Pless","is_ca":true},{"name":"Christopher A. Ahern","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0186571368230439,"gpt":0.3489608332709491,"spread":0.3303036964479052,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003775105,0.0007178263,0.0006948927,0.0009256997,0.0002086031,0.0005398407,0.0006353565,0.000808466,0.001161364],"category_scores_gemma":[0.0002490007,0.0002681373,0.0002321853,0.001016573,0.000568311,0.0008907286,0.0005167156,0.001133311,0.001553999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005872367,"about_ca_system_score_gemma":0.0003462851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003794223,"about_ca_topic_score_gemma":0.0006686972,"domain_scores_codex":[0.9998646,0.00002403,0.000009683918,0.00003053625,0.00005527476,0.00001590438],"domain_scores_gemma":[0.999911,0.0000349261,0.00002010848,0.000005626636,0.00001898468,0.000009391083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001104555,0.0001260483,0.0002345499,0.009035039,0.00005187398,0.0004753358,0.000131586,0.001194937,0.1493137,0.02192393,0.009918853,0.8074837],"study_design_scores_gemma":[0.00001809624,0.0001756124,0.0005170334,0.0006454778,0.00005161809,0.00150806,0.00005278697,0.0003939604,0.07128888,0.004951586,0.9203571,0.00003966508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001963933,0.9910946,0.002449837,0.0002014592,0.0002158005,0.00001124707,0.00003035511,0.00003634895,0.003996376],"genre_scores_gemma":[0.01016626,0.9840531,0.00233332,0.00021963,0.000129048,0.00002829624,0.00006862509,0.00001071409,0.002991024],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001161364,"threshold_uncertainty_score":0.004260719,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2144124034","doi":"10.1146/annurev.pharmtox.47.120505.105354","title":"Non-Nicotinic Therapies for Smoking Cessation","year":2007,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Varenicline; Bupropion; Smoking cessation; Medicine; Rimonabant; Nicotine; Pharmacology; Agonist; Psychiatry; Internal medicine; Receptor","authors":[{"name":"Eric Siu","is_ca":true},{"name":"Rachel F. Tyndale","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0350059507986346,"gpt":0.4125872593878511,"spread":0.3775813085892165,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000519117,0.0009104607,0.001120329,0.001982847,0.0004226859,0.0006188667,0.001038391,0.001278472,0.01210274],"category_scores_gemma":[0.0004994982,0.0001999776,0.0005191883,0.001274502,0.0004433319,0.0008747694,0.0006358757,0.001957655,0.008979931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005076811,"about_ca_system_score_gemma":0.0007065591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000725909,"about_ca_topic_score_gemma":0.0018882,"domain_scores_codex":[0.9997683,0.00003731851,0.00002184401,0.00003035988,0.0001248257,0.00001737936],"domain_scores_gemma":[0.9998196,0.00006799999,0.00002338095,0.00001175817,0.00005311976,0.00002420915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004295198,0.0001644434,0.0001249549,0.004682211,0.00005106236,0.0002500126,0.00004611521,0.0001058667,0.002571397,0.002854981,0.03833316,0.9507728],"study_design_scores_gemma":[0.00003078946,0.0001108719,0.0007918779,0.001565864,0.00004247357,0.001909819,0.00002895778,0.0000491466,0.0006888775,0.001923331,0.9928474,0.00001051935],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001798249,0.9937187,0.000230872,0.0003768834,0.0004381311,0.00001512526,0.00001874981,0.00002138522,0.005000192],"genre_scores_gemma":[0.00132471,0.9924297,0.0004359015,0.0004120123,0.0004537078,0.00002203905,0.00004999233,0.00000375229,0.004868281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01210274,"threshold_uncertainty_score":0.04048777,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2463506578","doi":"10.1146/annurev-pharmtox-010716-104952","title":"Changing Provider Behavior in the Context of Chronic Disease Management: Focus on Clinical Inertia","year":2016,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Health Policy Implementation Science","field":"Health Professions","cited_by":64,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Context (archaeology); Psychological intervention; Medicine; Guideline; Variety (cybernetics); Intensive care medicine; Psychology; Nursing; Computer science; Pathology","authors":[{"name":"Kim Lavoie","is_ca":true},{"name":"Joshua A. Rash","is_ca":true},{"name":"Tavis S. Campbell","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.3975449763680212,"gpt":0.6780330891740801,"spread":0.2804881128060589,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006323236,0.0005201448,0.001790671,0.002549439,0.0005954768,0.002678433,0.00113456,0.002036265,0.001935858],"category_scores_gemma":[0.01419154,0.0003044693,0.001451224,0.002992236,0.001285689,0.002174691,0.001477572,0.00242578,0.0003077665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002334795,"about_ca_system_score_gemma":0.008991676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007207627,"about_ca_topic_score_gemma":0.01491333,"domain_scores_codex":[0.9959389,0.002194152,0.0004587268,0.0002983404,0.0009139444,0.0001958687],"domain_scores_gemma":[0.9884059,0.009117395,0.00111782,0.0001785581,0.0009576838,0.0002226232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006770631,0.0001416625,0.002674785,0.0756734,0.0006828521,0.000201039,0.001513331,0.0003636233,0.0002549183,0.007189883,0.005789267,0.9054475],"study_design_scores_gemma":[0.0001749027,0.0006436415,0.03441316,0.3029346,0.003862615,0.003578329,0.005324144,0.0008591005,0.0009765173,0.01655956,0.6305168,0.0001566743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009292848,0.9930984,0.0003932101,0.004076155,0.0001813863,0.00003345768,0.00001487731,0.000004902687,0.001268318],"genre_scores_gemma":[0.01181213,0.9850377,0.001177346,0.001490351,0.0002129084,0.00005104769,0.00002066677,0.000003119568,0.0001946481],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007207627,"threshold_uncertainty_score":0.03344083,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2169595007","doi":"10.1146/annurev-pharmtox-010814-124302","title":"Mineralocorticoids in the Heart and Vasculature: New Insights for Old Hormones","year":2014,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Western University","funders":"","keywords":"Aldosterone; Mineralocorticoid receptor; Aldosterone synthase; Mineralocorticoid; Signal transduction; Endocrinology; Internal medicine; Pharmacology; Receptor; Hormone; Biology; Medicine; Cell biology; Renin–angiotensin system; Blood pressure","authors":[{"name":"Achim Lother","is_ca":false},{"name":"Martin Moser","is_ca":false},{"name":"Christoph Bode","is_ca":false},{"name":"Ross D. Feldman","is_ca":true},{"name":"Lutz Hein","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03931229712909192,"gpt":0.3841034115456682,"spread":0.3447911144165763,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007204641,0.0007555219,0.001322864,0.001713247,0.0004059266,0.001307496,0.0009278418,0.001268314,0.005018444],"category_scores_gemma":[0.0007077557,0.0002264616,0.0004436587,0.00173899,0.0008971817,0.002481625,0.0009855194,0.002506508,0.002704497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007380343,"about_ca_system_score_gemma":0.00133773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007867778,"about_ca_topic_score_gemma":0.001588168,"domain_scores_codex":[0.9997707,0.00004489889,0.00002618315,0.00003555553,0.00009755152,0.00002496992],"domain_scores_gemma":[0.9996362,0.0001646493,0.00003244025,0.000016078,0.0001000246,0.00005066082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001024911,0.00008773119,0.0002165896,0.014196,0.00008947297,0.0003793428,0.0001697484,0.0002565631,0.002842792,0.01193077,0.05713762,0.9125909],"study_design_scores_gemma":[0.00001002544,0.00004961196,0.0003120493,0.001519213,0.00003197451,0.0008074729,0.00007284916,0.0000353631,0.000160946,0.003900127,0.99309,0.00001045985],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006137789,0.9985531,0.00008045735,0.0004420247,0.0003028831,0.000001220733,0.000005888426,0.000004370914,0.0005486764],"genre_scores_gemma":[0.0005019513,0.9979976,0.00009605018,0.0002546151,0.0004807495,0.000002134717,0.00001169959,0.00000126383,0.0006538667],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005018444,"threshold_uncertainty_score":0.01678836,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2892360918","doi":"10.1146/annurev-pharmtox-010818-021807","title":"Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation","year":2018,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"National Institute on Aging; Weston Brain Institute; Eli Lilly and Company","keywords":"Disease; Translation (biology); Neuroscience; Neuroprotection; Neurodegeneration; Medicine; Bioinformatics; Therapeutic approach; Biology; Gene; Pathology; Genetics","authors":[{"name":"Miguel Moutinho","is_ca":false},{"name":"Juan F. Codocedo","is_ca":false},{"name":"Shweta S. Puntambekar","is_ca":false},{"name":"Gary E. Landreth","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.05949673359232888,"gpt":0.3891837764578573,"spread":0.3296870428655285,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063794,0.000844739,0.001426835,0.001823424,0.0003532623,0.001327457,0.001059384,0.001584204,0.004643164],"category_scores_gemma":[0.001101219,0.0002917729,0.0004595281,0.001599661,0.0009779964,0.00217889,0.000966711,0.003245001,0.003251167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000961136,"about_ca_system_score_gemma":0.001442185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007233318,"about_ca_topic_score_gemma":0.001454351,"domain_scores_codex":[0.9997094,0.00005763932,0.00004324947,0.00004668656,0.0001137206,0.00002922838],"domain_scores_gemma":[0.9993917,0.0002972564,0.00005413683,0.00002796144,0.0001736597,0.00005527623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009848515,0.00007584383,0.0001235242,0.01458472,0.0000747224,0.0002313729,0.0001174616,0.0003464209,0.003096218,0.01470233,0.04096298,0.9255859],"study_design_scores_gemma":[0.00001103455,0.00006410255,0.0001886346,0.002128731,0.00003936654,0.0006712647,0.000048399,0.00004507537,0.0004146501,0.003185454,0.9931931,0.00001018317],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007605741,0.9980166,0.0001203384,0.0005173031,0.0003510171,0.000003257645,0.00001140065,0.000007937383,0.0008960869],"genre_scores_gemma":[0.0004963846,0.9981007,0.0001523109,0.0003542429,0.0002458036,0.000005288437,0.00002012322,0.00000245907,0.0006228097],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004643164,"threshold_uncertainty_score":0.01553297,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3090949181","doi":"10.1146/annurev-pharmtox-030920-025745","title":"Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings","year":2020,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":49,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institutes of Health","keywords":"Pharmacogenetics; Medicine; Genetic testing; Drug; Drug response; Intensive care medicine; Pharmacology; Biology; Genotype; Genetics; Internal medicine; Gene","authors":[{"name":"Wan‐Chun Chang","is_ca":true},{"name":"Reo Tanoshima","is_ca":true},{"name":"Colin J.D. Ross","is_ca":true},{"name":"Bruce Carleton","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.4003053614121597,"gpt":0.5433675497631206,"spread":0.1430621883509609,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03096296,0.0007081682,0.001578128,0.001837105,0.0006729288,0.004249473,0.002479586,0.004298722,0.003751209],"category_scores_gemma":[0.03813602,0.0004991881,0.001265854,0.002087222,0.002684868,0.006229039,0.003263571,0.007932821,0.002221912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002282348,"about_ca_system_score_gemma":0.01495926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003803316,"about_ca_topic_score_gemma":0.005515273,"domain_scores_codex":[0.9862076,0.008047947,0.001316992,0.0007889279,0.003080764,0.0005577423],"domain_scores_gemma":[0.9495718,0.03870042,0.002337387,0.001212277,0.006847941,0.001330078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000457465,0.00008470758,0.0007390729,0.01396234,0.0001002647,0.0003139416,0.0005043157,0.0006905006,0.0005206612,0.0226048,0.02551785,0.9349158],"study_design_scores_gemma":[0.00003709102,0.0001514383,0.001365425,0.02667282,0.0001439271,0.001551925,0.0008600443,0.0004426614,0.0004882318,0.02737808,0.9408435,0.00006484236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005334079,0.9396938,0.005203109,0.04764871,0.001434012,0.00005613661,0.00004839795,0.00006799628,0.005314401],"genre_scores_gemma":[0.006108166,0.9677081,0.01121609,0.01221974,0.001627648,0.0001009373,0.00009449304,0.00002448906,0.0009004039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03096296,"threshold_uncertainty_score":0.1637498,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2470937536","doi":"10.1146/annurev-pharmtox-010716-104805","title":"Strategies to Develop Inhibitors of Motif-Mediated Protein-Protein Interactions as Drug Leads","year":2016,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Peptide; Computational biology; Drug discovery; Chemistry; Drug; Cell permeability; Bioavailability; Biochemistry; Combinatorial chemistry; Pharmacology; Biology","authors":[{"name":"Carles Corbi‐Verge","is_ca":true},{"name":"Michael Garton","is_ca":true},{"name":"Satra Nim","is_ca":true},{"name":"Philip M. Kim","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01375018672350009,"gpt":0.3532505196763746,"spread":0.3395003329528745,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005700766,0.0009887952,0.001044539,0.001886156,0.0002521122,0.001013823,0.001045467,0.0008803693,0.002789007],"category_scores_gemma":[0.0004276363,0.0004301575,0.0006276317,0.0009753443,0.0004806877,0.001192147,0.0007786011,0.002151476,0.002935994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006483711,"about_ca_system_score_gemma":0.0005204024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003577878,"about_ca_topic_score_gemma":0.0009144926,"domain_scores_codex":[0.999797,0.00003461155,0.00001705652,0.00004088479,0.00007880403,0.00003165164],"domain_scores_gemma":[0.9998862,0.00003653824,0.00002328522,0.000008825489,0.00002868278,0.00001649366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001309574,0.0004582838,0.0003002522,0.01026732,0.000174693,0.0007775623,0.0001725018,0.002705524,0.1198854,0.03562142,0.01737292,0.8121332],"study_design_scores_gemma":[0.00008737928,0.0005851156,0.0005263111,0.0008151292,0.0001309846,0.001749518,0.00003764683,0.0009953341,0.04667322,0.004678847,0.9436699,0.00005044933],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005482663,0.9615788,0.01620905,0.0008172277,0.0006386071,0.0002183984,0.0002231962,0.0002040115,0.01462807],"genre_scores_gemma":[0.02764512,0.9492012,0.01204464,0.0009001723,0.0002381764,0.0002981769,0.0004065891,0.00003662827,0.009229375],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002789007,"threshold_uncertainty_score":0.009330213,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2153985019","doi":"10.1146/annurev.pharmtox.010909.105826","title":"Pharmacogenetics of Drug Dependence: Role of Gene Variations in Susceptibility and Treatment","year":2010,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":45,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; U.S. Food and Drug Administration","keywords":"Pharmacogenetics; Drug; Genetic variation; Addiction; Heritability; Pharmacogenomics; Affect (linguistics); Biology; Gene; Genetics; Genotype; Pharmacology; Medicine; Psychology; Neuroscience","authors":[{"name":"Jibran Y. Khokhar","is_ca":true},{"name":"Charmaine S. Ferguson","is_ca":true},{"name":"Andy Z. X. Zhu","is_ca":true},{"name":"Rachel F. Tyndale","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.06599665463926711,"gpt":0.4535639195132581,"spread":0.387567264873991,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005868591,0.0006235048,0.001491553,0.001101464,0.0001542111,0.0007225533,0.0006927622,0.000829558,0.00298817],"category_scores_gemma":[0.0008217636,0.0001734912,0.0004120656,0.001563722,0.0003984081,0.000536533,0.0004738518,0.001044721,0.001797707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006053174,"about_ca_system_score_gemma":0.0009577678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001565388,"about_ca_topic_score_gemma":0.001893989,"domain_scores_codex":[0.9996728,0.0001013902,0.00003387657,0.00005327591,0.0001181696,0.0000205489],"domain_scores_gemma":[0.9996924,0.0001719641,0.00004470474,0.00001020115,0.00006166342,0.00001915161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000653898,0.00006170834,0.0009283175,0.004865518,0.0001152989,0.0003331879,0.00004291547,0.0003544131,0.001421987,0.003102987,0.01587437,0.9728338],"study_design_scores_gemma":[0.00005020598,0.0001934935,0.009958234,0.005105476,0.0002746029,0.006440867,0.0001011721,0.0003787166,0.001297968,0.008102104,0.9680522,0.00004484476],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002915124,0.9967369,0.0004099451,0.0005438369,0.0001077623,0.000005411048,0.00003209897,0.00001168568,0.001860791],"genre_scores_gemma":[0.001784926,0.9967145,0.0003483218,0.0001811811,0.0001676647,0.000007727715,0.00004775688,0.000002605072,0.000745296],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00298817,"threshold_uncertainty_score":0.009996414,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2612171362","doi":"10.1146/annurev-pharmtox-010617-052623","title":"The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control","year":2017,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary; Western University","funders":"Canadian Institutes of Health Research","keywords":"Vasomotor; Function (biology); Medicine; Neuroscience; Biology; Internal medicine","authors":[{"name":"Donald G. Welsh","is_ca":true},{"name":"Cam Ha T. Tran","is_ca":true},{"name":"Bjørn Olav Hald","is_ca":false},{"name":"María Sancho","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1180296726354858,"gpt":0.4576038518676289,"spread":0.3395741792321431,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004993879,0.0007742872,0.00135872,0.001671839,0.000369106,0.001908225,0.0009361329,0.001219197,0.003169636],"category_scores_gemma":[0.0005062695,0.0002741228,0.0004523456,0.001258966,0.0009544612,0.001871013,0.0008367642,0.001761893,0.002465641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007434431,"about_ca_system_score_gemma":0.001103285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969077,"about_ca_topic_score_gemma":0.0008802233,"domain_scores_codex":[0.9998111,0.00002367498,0.000025416,0.0000411986,0.00007070969,0.0000279375],"domain_scores_gemma":[0.9998146,0.00006567218,0.0000270834,0.00001005001,0.00005705611,0.00002563092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001286746,0.0001379982,0.000391176,0.0222194,0.00007822423,0.0006207483,0.0001968425,0.0005765338,0.02555097,0.0293057,0.02494848,0.8958452],"study_design_scores_gemma":[0.00001048142,0.0001739237,0.0008990358,0.002076892,0.00006792801,0.002509114,0.0001324331,0.0001896293,0.004945355,0.00737773,0.9815782,0.00003927947],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004500589,0.9954001,0.0005598303,0.000436288,0.000312354,0.000007264491,0.00003376899,0.00001448191,0.002785852],"genre_scores_gemma":[0.002489239,0.9952749,0.0004059487,0.0002125134,0.0002472062,0.00001251169,0.00004327589,0.000003612962,0.001310721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003169636,"threshold_uncertainty_score":0.01060343,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3201797647","doi":"10.1146/annurev-pharmtox-052120-084449","title":"Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies","year":2021,"lang":"en","type":"article","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Tuberous sclerosis; Epilepsy; Precision medicine; Medicine; Encephalopathy; Pediatrics; Intellectual disability; Bioinformatics; Psychiatry; Pathology; Biology","authors":[{"name":"Kenneth A. Myers","is_ca":true},{"name":"Ingrid E. Scheffer","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02155088194838613,"gpt":0.3049846492320589,"spread":0.2834337672836728,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003455686,0.0008419729,0.001301427,0.002066808,0.0006749382,0.002297951,0.0013134,0.00209636,0.006294434],"category_scores_gemma":[0.00444692,0.0002635769,0.001094649,0.0008873859,0.001872909,0.002048192,0.002393567,0.003613671,0.002102542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001469116,"about_ca_system_score_gemma":0.001686777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009591536,"about_ca_topic_score_gemma":0.001786903,"domain_scores_codex":[0.9988574,0.0004032384,0.00008822352,0.0001644034,0.0003960432,0.00009067988],"domain_scores_gemma":[0.9972779,0.001552999,0.00030316,0.0002304365,0.0004771391,0.0001583779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00030819,0.0002170412,0.001076805,0.004267293,0.000326579,0.001409466,0.0003774158,0.001651806,0.009940595,0.09276433,0.04380534,0.8438551],"study_design_scores_gemma":[0.0001204886,0.0006130615,0.001384639,0.002456704,0.0002816427,0.003756449,0.0002630168,0.001321716,0.006847579,0.1100081,0.8728554,0.00009112928],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004378051,0.8845672,0.04565285,0.03318565,0.003015409,0.0001396552,0.000272176,0.000745749,0.02804339],"genre_scores_gemma":[0.07577406,0.8352033,0.05287725,0.02010752,0.004101202,0.0003642941,0.0005772907,0.0001518701,0.01084326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006294434,"threshold_uncertainty_score":0.02105695,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3088395574","doi":"10.1146/annurev-pharmtox-031320-104151","title":"Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy","year":2020,"lang":"en","type":"article","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"BC Children's Hospital; University of British Columbia; Western University","funders":"","keywords":"Pharmacogenomics; Medicine; Adverse effect; Pharmacogenetics; Cancer; Intensive care medicine; Dosing; Drug; Oncology; Pediatric cancer; Cancer treatment; Clinical trial; Chemotherapy; Internal medicine; Pharmacology; Genotype","authors":[{"name":"Abdelbaset Elzagallaai","is_ca":true},{"name":"Bruce Carleton","is_ca":true},{"name":"Michael Rieder","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04181483349666665,"gpt":0.3809169743825409,"spread":0.3391021408858743,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001911112,0.0004327505,0.0009469525,0.001000053,0.0002234826,0.001372359,0.0004460268,0.0007613091,0.001427329],"category_scores_gemma":[0.002212981,0.0001649732,0.0004115659,0.001082997,0.000679737,0.001102313,0.0007853089,0.001819066,0.0004775347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006162496,"about_ca_system_score_gemma":0.001172603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373281,"about_ca_topic_score_gemma":0.001464409,"domain_scores_codex":[0.9994004,0.0003164709,0.000047963,0.00005436552,0.0001463416,0.0000344447],"domain_scores_gemma":[0.9985883,0.0008403616,0.0002512524,0.00004886215,0.0001822942,0.00008898022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001425556,0.0001654679,0.005554861,0.004181917,0.0002347779,0.0003596813,0.0001608973,0.0008846498,0.00656991,0.01626656,0.01585802,0.9496205],"study_design_scores_gemma":[0.0001040223,0.001631058,0.01837208,0.003524544,0.0004673868,0.00480462,0.0004408683,0.00149274,0.01200685,0.04455641,0.9125153,0.00008401369],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004142063,0.9749979,0.004855909,0.01116712,0.0004231152,0.00003342381,0.00009821575,0.00006561575,0.004216571],"genre_scores_gemma":[0.02239756,0.9673759,0.005975748,0.002090619,0.001008587,0.00003007357,0.00006925017,0.00001227338,0.001039997],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001911112,"threshold_uncertainty_score":0.0101071,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2101849950","doi":"10.1146/annurev-pharmtox-010814-124446","title":"Intraclass Differences Among Antihypertensive Drugs","year":2014,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"NOSM University; University of Alberta; St. Paul's Hospital; University of British Columbia; Western University","funders":"","keywords":"Thiazide; Atenolol; Hydrochlorothiazide; Medicine; Pharmacology; Blood pressure; Losartan; Internal medicine; Renin–angiotensin system","authors":[{"name":"Ross D. Feldman","is_ca":true},{"name":"Yasin Hussain","is_ca":true},{"name":"Laura M. Kuyper","is_ca":true},{"name":"Finlay A. McAlister","is_ca":true},{"name":"Raj Padwal","is_ca":true},{"name":"Sheldon W. Tobe","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03683259400486553,"gpt":0.3707957297468831,"spread":0.3339631357420175,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02846412,0.00105163,0.003957153,0.005185537,0.0003690158,0.002017538,0.001748626,0.001046318,0.00645862],"category_scores_gemma":[0.07030139,0.0004449971,0.006870695,0.005532598,0.001126237,0.001392623,0.001024467,0.001348396,0.0005898718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002060786,"about_ca_system_score_gemma":0.002905456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002270736,"about_ca_topic_score_gemma":0.004312753,"domain_scores_codex":[0.962885,0.01412143,0.008182152,0.004712436,0.009723043,0.0003758625],"domain_scores_gemma":[0.885532,0.09646729,0.008488828,0.002243322,0.007004418,0.0002641673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001235018,0.0001026006,0.04617276,0.1262968,0.05831102,0.000180238,0.0005832677,0.00155464,0.0003902088,0.005224829,0.0184414,0.7415071],"study_design_scores_gemma":[0.002008064,0.00229135,0.3052675,0.1444061,0.1956938,0.004590211,0.001549771,0.00829038,0.002865895,0.04985055,0.2826445,0.0005418771],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003702165,0.9855763,0.0048032,0.0007291,0.0009591963,0.0003002962,0.001177827,0.00005121061,0.002700526],"genre_scores_gemma":[0.2126074,0.7562338,0.0185086,0.001696116,0.002210243,0.001743765,0.0042999,0.00009515829,0.002605032],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02846412,"threshold_uncertainty_score":0.1505345,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W2100669494","doi":"10.1146/annurev-pharmtox-011613-135930","title":"Fetal and Perinatal Exposure to Drugs and Chemicals: Novel Biomarkers of Risk","year":2013,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Public Health Agency of Canada","keywords":"Medicine; Fetus; Randomized controlled trial; Intensive care medicine; Clinical trial; Pregnancy; Obstetrics; Bioinformatics; Pathology; Biology","authors":[{"name":"Fatma Etwel","is_ca":true},{"name":"Janine R. Hutson","is_ca":true},{"name":"Parvaz Madadi","is_ca":true},{"name":"Joey Gareri","is_ca":true},{"name":"Gideon Koren","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.0258661569542044,"gpt":0.3875957777014554,"spread":0.361729620747251,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001371096,0.0007912377,0.002395276,0.002137685,0.0002173241,0.001218344,0.0007917609,0.001243083,0.003004769],"category_scores_gemma":[0.002619297,0.0002633229,0.0008904528,0.002215905,0.0007070822,0.001072273,0.0006359667,0.001533401,0.000864469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006517066,"about_ca_system_score_gemma":0.001461054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009299926,"about_ca_topic_score_gemma":0.001766231,"domain_scores_codex":[0.9992694,0.0002378266,0.0001116713,0.0001041065,0.0002442232,0.00003285882],"domain_scores_gemma":[0.9978326,0.001697636,0.0002215739,0.00003908194,0.0001751073,0.00003403414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008258304,0.00005647809,0.0004908758,0.03333436,0.0002607755,0.0001544964,0.00005031766,0.0001999321,0.0009523992,0.002994856,0.008895023,0.9525279],"study_design_scores_gemma":[0.00007134753,0.000374661,0.005155277,0.03688086,0.001307276,0.004093549,0.0002287205,0.0002709306,0.001945574,0.007947696,0.9416547,0.0000692946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008755096,0.9989791,0.0001344799,0.000238084,0.00006654266,0.000004915678,0.00001923859,0.000003621526,0.0004665534],"genre_scores_gemma":[0.0008000049,0.9986073,0.0002067687,0.0001306946,0.00008137253,0.000007483228,0.00001668356,8.815644e-7,0.0001488556],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003004769,"threshold_uncertainty_score":0.01005191,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3202320335","doi":"10.1146/annurev-pharmtox-052120-020445","title":"Repurposing Colchicine for Heart Disease","year":2021,"lang":"en","type":"article","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Colchicine; Medicine; Familial Mediterranean fever; Gout; Pericarditis; Internal medicine; Atrial fibrillation; Disease; Coronary artery disease; Cardiology; Repurposing; Aspirin; Intensive care medicine","authors":[{"name":"Nadia Bouabdallaoui","is_ca":true},{"name":"Jean‐Claude Tardif","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.009032826707314418,"gpt":0.3227612623866922,"spread":0.3137284356793777,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155456,0.0004542808,0.0003731679,0.0009823448,0.0002228847,0.0005460458,0.0002739582,0.0005671151,0.004225046],"category_scores_gemma":[0.000231707,0.0001078694,0.0003016266,0.0004919696,0.0003273689,0.0005108409,0.0004065754,0.001030006,0.002365047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002574015,"about_ca_system_score_gemma":0.0002258438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002871134,"about_ca_topic_score_gemma":0.0009937277,"domain_scores_codex":[0.9998732,0.00002523866,0.00001451361,0.00001873156,0.0000545191,0.00001386905],"domain_scores_gemma":[0.9999292,0.00002178989,0.00001561915,0.000004604127,0.00001681271,0.00001197528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002669671,0.0001667059,0.0004798373,0.007860001,0.0001315836,0.001386989,0.000140098,0.0002333773,0.09742562,0.005987083,0.05537574,0.830546],"study_design_scores_gemma":[0.00003849219,0.000319115,0.001396245,0.0006782635,0.00006716122,0.003728094,0.00005343785,0.00007838781,0.01714514,0.001748812,0.9747238,0.00002309896],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003339432,0.985647,0.001060691,0.001559666,0.001310115,0.00002785572,0.0001057971,0.00005640232,0.006893108],"genre_scores_gemma":[0.01870669,0.968227,0.001281545,0.00188264,0.001357333,0.00003502875,0.00022809,0.00002097385,0.00826072],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004225046,"threshold_uncertainty_score":0.01413417,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W3043081900","doi":"10.1146/annurev-pharmtox-010919-023645","title":"Hormonal Signaling Actions on Kv7.1 (KCNQ1) Channels","year":2020,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of British Columbia","funders":"","keywords":"Repolarization; Cell biology; Potassium channel; Cardiac action potential; Biology; Membrane potential; Neuroscience; Chemistry; Biophysics; Electrophysiology","authors":[{"name":"Emely Thompson","is_ca":true},{"name":"Jodene Eldstrom","is_ca":true},{"name":"David Fedida","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04401116660591566,"gpt":0.3952752697551177,"spread":0.351264103149202,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743025,0.0005642828,0.0007693443,0.001096026,0.0001761795,0.0005199126,0.0003886748,0.0004490093,0.004082248],"category_scores_gemma":[0.00026868,0.0001590534,0.0004034817,0.0009732724,0.0001899707,0.0005978725,0.0004015924,0.0008661263,0.001678835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003534155,"about_ca_system_score_gemma":0.0004500577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007169307,"about_ca_topic_score_gemma":0.001187478,"domain_scores_codex":[0.9999273,0.000009008085,0.00001114684,0.00001486698,0.00002662009,0.00001108819],"domain_scores_gemma":[0.9999336,0.00002762578,0.00001082297,0.000002033893,0.00001873727,0.000007128181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001043684,0.00005300282,0.0001920729,0.01787133,0.00009415922,0.0002569006,0.0000611529,0.0003588911,0.006142598,0.003288956,0.02337523,0.9482013],"study_design_scores_gemma":[0.00002194878,0.0001280843,0.001370408,0.002063221,0.0001324806,0.001614526,0.00004495435,0.00008970404,0.001488182,0.001281524,0.9917448,0.0000200628],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003871168,0.9974962,0.000143484,0.000189693,0.0002098409,0.000004841657,0.00004738853,0.00001303137,0.00150836],"genre_scores_gemma":[0.001163606,0.9975792,0.0001145848,0.0001245337,0.0001226064,0.000004947247,0.00004909649,0.000001457229,0.0008400526],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004082248,"threshold_uncertainty_score":0.01365656,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4406811653","doi":"10.1146/annurev-pharmtox-061724-080727","title":"G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders","year":2025,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Toronto","funders":"","keywords":"G protein-coupled receptor; Context (archaeology); Receptor; Neuroscience; Computational biology; Drug discovery; Drug development; Function (biology); Biology; Functional selectivity; Drug; Chemistry; Bioinformatics; Pharmacology; Cell biology; Biochemistry","authors":[{"name":"Ahmed Hasbi","is_ca":true},{"name":"Susan R. George","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01276795094520688,"gpt":0.3171485547011193,"spread":0.3043806037559124,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003974218,0.0008116482,0.001085575,0.001437766,0.0002350596,0.0008060905,0.0008497977,0.00113715,0.004878076],"category_scores_gemma":[0.0004097225,0.0002069145,0.0003674028,0.001388101,0.0004620102,0.001106364,0.0007303951,0.001988213,0.003393058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000453742,"about_ca_system_score_gemma":0.0007278697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005496164,"about_ca_topic_score_gemma":0.001127844,"domain_scores_codex":[0.9998803,0.00002159326,0.00001513383,0.00002362211,0.00004468756,0.00001466029],"domain_scores_gemma":[0.9998506,0.00006404953,0.0000211505,0.000005396956,0.00003828915,0.00002058408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007512908,0.0000668799,0.000124278,0.01040558,0.00005118489,0.000261786,0.00005260946,0.0002683112,0.001896709,0.00562473,0.03916826,0.9420047],"study_design_scores_gemma":[0.00001470371,0.00008101494,0.0006002623,0.00191549,0.00006384384,0.001576424,0.00003640228,0.00005359931,0.0003328303,0.002103579,0.9932097,0.00001232481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001064789,0.998152,0.0001126329,0.0002514815,0.0002429703,0.000003873747,0.00001423201,0.000009859957,0.001106462],"genre_scores_gemma":[0.0005977286,0.9980842,0.0001163954,0.0002201695,0.0002057151,0.000005241474,0.00002429481,0.000001736895,0.0007445312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004878076,"threshold_uncertainty_score":0.0163188,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4402503401","doi":"10.1146/annurev-pharmtox-061724-080852","title":"Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies","year":2024,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute","keywords":"G protein-coupled receptor; Immunotherapy; Immune system; Tumor microenvironment; Immune checkpoint; Receptor; Cancer immunotherapy; Cancer; CD8; Blockade; Cancer research; T cell; Computational biology; Biology; Medicine; Bioinformatics; Immunology; Internal medicine","authors":[{"name":"John Stagg","is_ca":true},{"name":"Zhiyong Wang","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.03210126391893653,"gpt":0.3916026465407169,"spread":0.3595013826217803,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004660495,0.000646832,0.0008770955,0.00155873,0.0002309729,0.0008243651,0.0006178372,0.001013358,0.005042028],"category_scores_gemma":[0.0003476996,0.0002409875,0.0004692705,0.001231744,0.0003920767,0.001133118,0.0006860498,0.002372991,0.00350839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000533098,"about_ca_system_score_gemma":0.0008017497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005428005,"about_ca_topic_score_gemma":0.001179347,"domain_scores_codex":[0.9998474,0.00002835857,0.00001573448,0.00002383522,0.00006273339,0.00002197668],"domain_scores_gemma":[0.9998558,0.00006106122,0.00001765429,0.000005599593,0.00004086933,0.0000189964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007287395,0.0001128205,0.000127915,0.01082911,0.00006126789,0.0002097442,0.00005392043,0.0004804046,0.004619998,0.009189747,0.0424918,0.9317505],"study_design_scores_gemma":[0.00001278517,0.00008764531,0.0003124272,0.001360049,0.00004158837,0.0006017961,0.00002363437,0.00008634487,0.0004538711,0.001844038,0.9951656,0.00001026189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001897395,0.9966686,0.0002223436,0.0004317938,0.0004901867,0.000006946228,0.00001888499,0.00001460101,0.001956909],"genre_scores_gemma":[0.0008407457,0.9971244,0.0002185595,0.0002950031,0.0002618151,0.000007470027,0.00002718799,0.00000193259,0.001222932],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005042028,"threshold_uncertainty_score":0.01686722,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4387298621","doi":"10.1146/annurev-pharmtox-051921-013930","title":"Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury","year":2023,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Traumatic Brain Injury and Neurovascular Disturbances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Alberta","funders":"","keywords":"Traumatic brain injury; Medicine; Chronic traumatic encephalopathy; Dementia; Intensive care medicine; Disease; Epilepsy; Psychiatry; Poison control; Injury prevention; Internal medicine; Concussion; Medical emergency","authors":[{"name":"Laszlo F. Locskai","is_ca":true},{"name":"Hadeel Alyenbaawi","is_ca":false},{"name":"W. Ted Allison","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.04135778569731158,"gpt":0.4002319902360794,"spread":0.3588742045387678,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004574094,0.0006691193,0.001193718,0.001938753,0.0002028477,0.0007914603,0.0007382727,0.0008695476,0.004318656],"category_scores_gemma":[0.0007546872,0.0002081648,0.000555915,0.001388463,0.0002834585,0.0008247144,0.0004761161,0.001529115,0.001567482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003633647,"about_ca_system_score_gemma":0.0006446387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006601678,"about_ca_topic_score_gemma":0.001818748,"domain_scores_codex":[0.9998611,0.00003216806,0.00002668991,0.00001982234,0.00004788728,0.0000123083],"domain_scores_gemma":[0.9996949,0.0001759307,0.00004969895,0.000007854192,0.00005341405,0.00001822879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001245611,0.0001112719,0.0001567819,0.02419789,0.000126067,0.0002167471,0.00005168222,0.0002723951,0.001145394,0.002628265,0.01660221,0.9543667],"study_design_scores_gemma":[0.00006165612,0.0002259588,0.001209619,0.009277897,0.0002621916,0.001882568,0.0000599266,0.0001166693,0.0006470314,0.001950472,0.9842873,0.00001874579],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000165976,0.9985889,0.00005252721,0.0001361318,0.000109358,0.00000563908,0.00001741401,0.00000616975,0.0009180228],"genre_scores_gemma":[0.0009482757,0.998239,0.000123696,0.0001575252,0.0000970576,0.000007550441,0.00002674519,0.00000127237,0.0003988773],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004318656,"threshold_uncertainty_score":0.01444733,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4406811681","doi":"10.1146/annurev-pharmtox-051921-084536","title":"Pharmacology of Intestinal Inflammation and Repair","year":2025,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"University of Calgary","funders":"HORIZON EUROPE European Innovation Council; Fondation pour la Recherche Médicale; Région Occitanie Pyrénées-Méditerranée; Agence Nationale de la Recherche; European Commission; Crohn's and Colitis Foundation","keywords":"Inflammation; Disease; Pathogenesis; Medicine; Inflammatory bowel disease; Tissue repair; Immunology; Bioinformatics; Biology; Pathology","authors":[{"name":"Céline Deraison","is_ca":false},{"name":"Nathalie Vergnolle","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02576769401455482,"gpt":0.3867747809986091,"spread":0.3610070869840543,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366287,0.0007191107,0.0008720979,0.001368122,0.0003183985,0.001050858,0.0005659237,0.0007729774,0.005429943],"category_scores_gemma":[0.0002339038,0.00017275,0.0003357655,0.0009548058,0.0004259,0.0008587271,0.0007541357,0.001345404,0.003176719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004146684,"about_ca_system_score_gemma":0.0006819204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004766645,"about_ca_topic_score_gemma":0.0007897998,"domain_scores_codex":[0.9998815,0.00002501337,0.00001238001,0.00001984075,0.00004465771,0.00001648704],"domain_scores_gemma":[0.9999266,0.00002046827,0.00001258998,0.000004174127,0.00002389519,0.00001233743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001344733,0.0001661993,0.0001976671,0.02350176,0.00008127963,0.000456756,0.0001602612,0.0004192863,0.01892113,0.01787402,0.03040416,0.9076831],"study_design_scores_gemma":[0.00001595159,0.0001601047,0.0008383194,0.001643913,0.0000411924,0.001472431,0.00005927917,0.000080315,0.0019948,0.003126937,0.9905501,0.00001670418],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005130211,0.9926513,0.0004810612,0.000438275,0.0004639102,0.00001478681,0.00005669456,0.00002333972,0.005357694],"genre_scores_gemma":[0.002751945,0.9938426,0.0003447628,0.0002632309,0.0003038766,0.00001673203,0.00006230111,0.000002940117,0.00241156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005429943,"threshold_uncertainty_score":0.01816499,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4413511801","doi":"10.1146/annurev-pharmtox-062124-033726","title":"Gβγ Signaling: Lessons Across the Cellular Multiverse","year":2025,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Endoplasmic reticulum; Golgi apparatus; Cell biology; Subcellular localization; Mitochondrion; Nucleus; Biology; Effector; G protein; Signal transduction; Protein subunit; Cytoplasm; Biochemistry","authors":[{"name":"Sana Qayum","is_ca":true},{"name":"Darlaine Pétrin","is_ca":true},{"name":"Jason C. Tanny","is_ca":true},{"name":"Terence E. Hébert","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.02734227112528532,"gpt":0.3877529014956961,"spread":0.3604106303704108,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005923753,0.0007257488,0.0008919312,0.001460903,0.0003427817,0.001260845,0.0007556213,0.001199938,0.002572426],"category_scores_gemma":[0.0004141714,0.0002456775,0.0003336383,0.001558357,0.0008602795,0.002463532,0.001257382,0.002657987,0.002336566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008307702,"about_ca_system_score_gemma":0.001060065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006884401,"about_ca_topic_score_gemma":0.001061663,"domain_scores_codex":[0.9998785,0.00002060426,0.00001242284,0.00002780049,0.00004237055,0.00001837107],"domain_scores_gemma":[0.9998369,0.00008135004,0.00001258362,0.000008681667,0.000033265,0.00002714536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008982163,0.00005461982,0.0001355595,0.008024611,0.00005982098,0.0004445242,0.0002137464,0.0005795028,0.004820933,0.03939016,0.03690566,0.9092812],"study_design_scores_gemma":[0.000005340054,0.00004426463,0.0002605664,0.00122957,0.00002577171,0.0005035594,0.0001058819,0.00007235722,0.0005270664,0.008662571,0.9885536,0.00000949113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001998999,0.9965306,0.0003177007,0.0008964587,0.0003889142,0.000001856397,0.00001056358,0.00001056905,0.001643483],"genre_scores_gemma":[0.001150908,0.9971055,0.0001933446,0.0004063635,0.0003293322,0.00000377421,0.00001478851,0.000002794057,0.0007931889],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002572426,"threshold_uncertainty_score":0.008605599,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4402970108","doi":"10.1146/annurev-pharmtox-031524-021631","title":"Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review","year":2024,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false},"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Drug development; Clinical trial; MEDLINE; Cochrane Library; Population; Disease; Intensive care medicine; Meta-analysis; Drug; Pharmacology; Internal medicine; Biology; Environmental health","authors":[{"name":"Benoît Delabays","is_ca":true},{"name":"Chiara Paoli","is_ca":false},{"name":"Andrea Miller-Nesbitt","is_ca":true},{"name":"Vincent Mooser","is_ca":true}],"retraction":null,"screen_n_in":null,"score":{"opus":0.1570616094300459,"gpt":0.5753460924345787,"spread":0.4182844830045328,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02039954,0.001628081,0.005614435,0.01065805,0.0006702815,0.003846962,0.002275095,0.00317029,0.006094863],"category_scores_gemma":[0.05271102,0.0009142412,0.004714844,0.01124878,0.001200883,0.003567104,0.002099704,0.002121518,0.001143264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004434245,"about_ca_system_score_gemma":0.01572642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00311068,"about_ca_topic_score_gemma":0.006999333,"domain_scores_codex":[0.9908186,0.003947127,0.002770686,0.0004112785,0.001804086,0.0002482157],"domain_scores_gemma":[0.9432447,0.04627532,0.005457525,0.0009760997,0.003662084,0.00038425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001922248,0.0000407615,0.0001643875,0.6061696,0.001610926,0.0001124702,0.0002456035,0.0003019228,0.0004419102,0.00272979,0.01046181,0.3775287],"study_design_scores_gemma":[0.0001029441,0.000124774,0.000567125,0.8951624,0.004241256,0.0001889673,0.0001633792,0.0000903634,0.0002017631,0.001647298,0.09748641,0.00002329934],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001058577,0.9983048,0.0002262814,0.0004868235,0.0001990691,0.0001880607,0.00005518433,0.00001057309,0.0004232528],"genre_scores_gemma":[0.001044168,0.997053,0.0007391439,0.000544252,0.00007729148,0.0003289184,0.00007156827,0.000005321569,0.0001363297],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02039954,"threshold_uncertainty_score":0.1078843,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null},{"id":"W4414109894","doi":"10.1146/annurev-pharmtox-062124-015046","title":"Incretin Signaling Neighborhoods and Adverse Drug Reactions","year":2025,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false},"ca_institutions":"","funders":"Science for Life Laboratory; Vetenskapsrådet; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden; Eli Lilly and Company; European Foundation for the Study of Diabetes; Robert Bosch Stiftung; European Commission; Novo Nordisk; Diamond Light Source; McGill University; European Federation of Pharmaceutical Industries and Associations; Kungliga Tekniska Högskolan","keywords":"Incretin; Drug; Type 2 diabetes; Receptor; Drug reaction; Functional selectivity; Adverse effect; Action (physics)","authors":[{"name":"Shane C. Wright","is_ca":false},{"name":"Peter Lindquist","is_ca":false},{"name":"Mette M. Rosenkilde","is_ca":false},{"name":"Volker M. Lauschke","is_ca":false}],"retraction":null,"screen_n_in":null,"score":{"opus":0.01226697839496736,"gpt":0.340526356126137,"spread":0.3282593777311696,"validation_status":"score_only:v0-immature-baseline"},"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005921476,0.0006330699,0.001036714,0.001311574,0.000263078,0.0009195581,0.000575081,0.001048083,0.007113332],"category_scores_gemma":[0.0008728444,0.0002005292,0.0005282399,0.001084776,0.0003067872,0.0007140638,0.0006642346,0.001435048,0.002951534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004865349,"about_ca_system_score_gemma":0.0007389938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005404786,"about_ca_topic_score_gemma":0.001054541,"domain_scores_codex":[0.9997208,0.00005272836,0.00004139435,0.00004525292,0.0001154735,0.00002443499],"domain_scores_gemma":[0.9996369,0.0001717585,0.0000687522,0.00001120776,0.00008614949,0.00002525579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005241501,0.00004682727,0.0001582666,0.008318833,0.00007571985,0.0002186178,0.00003357367,0.0001809673,0.001005042,0.003545899,0.03384364,0.9525201],"study_design_scores_gemma":[0.0000222547,0.00009303358,0.000782996,0.003195646,0.0001193277,0.002354886,0.00003728083,0.00008852428,0.0006501037,0.002272032,0.9903668,0.00001702052],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001423515,0.9969939,0.0002329351,0.0003555414,0.000228338,0.000006597325,0.00003419957,0.00001560455,0.001990494],"genre_scores_gemma":[0.001141595,0.9962832,0.0002110306,0.0004114336,0.0003047547,0.00001162739,0.00005832772,0.000002920449,0.001575089],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007113332,"threshold_uncertainty_score":0.0237965,"prediction_status":"machine_predicted_unvalidated"},"labels":[],"label_agreement":null}]}