{"id":"W1002711513","doi":"10.7150/jca.11709","title":"Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis","year":2015,"lang":"en","type":"review","venue":"Journal of Cancer","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Heart, Lung, and Blood Institute; American Heart Association","keywords":"Carcinogenesis; Esophageal cancer; Cancer research; Cancer; Polarity (international relations); Medicine; Cell polarity; Suppressor; Biology; Pathology; Internal medicine; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006888829,0.0003349546,0.001378676,0.0001226312,0.00005238538,0.00002635665,0.0004783043,0.0004812696,0.00009769831],"category_scores_gemma":[0.0002309453,0.0002604761,0.0006543921,0.0001438422,0.0001479941,0.000009213222,0.0001367618,0.0002976985,0.000001890877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142064,"about_ca_system_score_gemma":0.001589341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001664389,"about_ca_topic_score_gemma":0.00001177219,"domain_scores_codex":[0.9976797,0.000198297,0.001070742,0.0002633974,0.0005107035,0.0002771973],"domain_scores_gemma":[0.997335,0.0000529919,0.001334363,0.0002447243,0.0008630131,0.0001699768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002556806,0.0001249853,0.001686668,0.008075665,0.001483162,0.00005747424,0.00007646436,0.00007001629,0.00592901,0.00002020753,0.009352435,0.9728682],"study_design_scores_gemma":[0.0003796291,0.0001360164,0.00007912145,0.004251876,0.0009656511,0.00009991789,0.00001989992,0.000001168939,0.01288881,0.0000370722,0.9808221,0.0003187477],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003796752,0.9944596,0.00006667511,0.00004672542,0.001273166,0.0001190721,0.0001553881,0.000003128561,0.00007946785],"genre_scores_gemma":[0.002261422,0.9935393,0.000999083,0.00003488081,0.002690145,0.00001529466,0.00002404256,0.00005882053,0.0003770375],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9725495,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05303382527208586,"score_gpt":0.3873715693174544,"score_spread":0.3343377440453685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}