{"id":"W1003598251","doi":"10.1016/j.virusres.2015.07.007","title":"K312 and E446 are involved in HCV RNA translation modulation by NS5A domains II and III","year":2015,"lang":"en","type":"article","venue":"Virus Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"NS5A; Biology; Subgenomic mRNA; Replicon; Virology; Viral replication; Translation (biology); Mutation; Context (archaeology); Mutant; Genetics; RNA; Cell biology; Hepatitis C virus; Virus; Hepacivirus; Genome; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002675286,0.0001493894,0.0003176526,0.0006894807,0.0002113108,0.00007000153,0.0001090389,0.0002148433,0.00005632186],"category_scores_gemma":[0.0006373837,0.0001402106,0.0000253704,0.0008473482,0.0003147174,0.000301177,0.0001544013,0.0007530928,0.00004027635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647618,"about_ca_system_score_gemma":0.0002374849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004002942,"about_ca_topic_score_gemma":0.004330293,"domain_scores_codex":[0.9967564,0.000444707,0.000324793,0.0004634396,0.001399588,0.0006110363],"domain_scores_gemma":[0.9985242,0.0002171395,0.00003708623,0.0003232403,0.0003537386,0.0005445629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002436298,0.0006386301,0.2509194,0.0003413064,0.0000790968,0.0001837477,0.007932199,0.00002224736,0.1947623,0.0003206415,0.02490863,0.5174555],"study_design_scores_gemma":[0.04814853,0.005343713,0.3621757,0.001211055,0.00006261021,0.00003220002,0.005573696,0.120616,0.04612282,0.007949783,0.4013103,0.00145364],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852513,0.002189138,0.00009792442,0.002271072,0.00002826266,0.0009934196,0.00003547181,0.00003889446,0.009094529],"genre_scores_gemma":[0.9968228,0.001666573,0.0002719357,0.00008014901,0.00009250823,0.00008016952,0.00005974985,0.00003609966,0.0008899535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5160018,"threshold_uncertainty_score":0.6051278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2039305834308083,"score_gpt":0.4210093366947784,"score_spread":0.21707875326397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}