{"id":"W1005324451","doi":"10.1038/npre.2011.6477.1","title":"Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs","year":2011,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; North York General Hospital; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Medicine; Toxic epidermal necrolysis; Carbamazepine; Phenytoin; Population; Toxicity; Lamotrigine; Internal medicine; Gastroenterology; Immunology; Epilepsy; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716123,0.0004218052,0.0002219112,0.0006316542,0.0003434378,0.0002850439,0.0001774567,0.0003497459,0.002759809],"category_scores_gemma":[0.001258363,0.0001338431,0.0002368678,0.000395024,0.0002976788,0.0001761583,0.0001888072,0.0003418429,0.0002201657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092846,"about_ca_system_score_gemma":0.0002310456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003474646,"about_ca_topic_score_gemma":0.002101076,"domain_scores_codex":[0.9997011,0.00009003286,0.00002874458,0.00006224949,0.00005897189,0.00005889113],"domain_scores_gemma":[0.9991946,0.0002399998,0.0002528867,0.00004230024,0.00009392346,0.0001762831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002791288,0.00005405476,0.9955117,0.000006045841,0.0000431752,0.0005452601,0.0000379484,0.00004089886,0.002111964,0.00002507665,0.0000611557,0.001283711],"study_design_scores_gemma":[0.000009749197,0.0001318619,0.9981456,0.000003204509,0.00001919043,0.001127239,0.00005936735,0.000188758,0.0002057374,0.00001848926,0.00008897184,0.000001895907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999605,0.00006954601,0.00004009571,0.00001686909,0.00000323408,0.000003597872,0.00004376907,0.000001817372,0.0002160087],"genre_scores_gemma":[0.9997683,0.00002116391,0.00003991728,0.00001044354,0.000007303805,0.000002504389,0.00005680509,9.371204e-7,0.00009264066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003474646,"threshold_uncertainty_score":0.009232521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388481556481748,"score_gpt":0.2710541095246053,"score_spread":0.2571692939597879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}