{"id":"W1024407832","doi":"10.1161/circ.118.suppl_18.s_708-c","title":"Abstract 2331: BRCA1 Limits Inflammation Induced Apoptosis And Improves Endothelial Function: A Novel Role Of DNA Repair Genes In Vascular Homeostasis","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Apoptosis; Medicine; Inflammation; Endothelial stem cell; DNA laddering; Cancer research; Enos; Gene silencing; Immunology; Downregulation and upregulation; Cell biology; Programmed cell death; Biology; Endocrinology; Nitric oxide; Nitric oxide synthase; Gene; DNA fragmentation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543123,0.0005074179,0.0004610733,0.0002405578,0.0001621453,0.0005010642,0.000309346,0.0004067445,0.004491433],"category_scores_gemma":[0.0001307915,0.0001199746,0.0002483115,0.000150108,0.0003652176,0.0002586912,0.0001589414,0.0009677532,0.0007029793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000365926,"about_ca_system_score_gemma":0.0003686408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004075897,"about_ca_topic_score_gemma":0.0002994067,"domain_scores_codex":[0.9999216,0.00001069952,0.000006179074,0.00001969385,0.00002266365,0.0000191422],"domain_scores_gemma":[0.9999229,0.00001369121,0.00002507603,0.000006208729,0.00001195767,0.0000202306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111053,0.000280782,0.000286918,0.0003544823,0.00002827963,0.0002324954,0.00002793665,0.0001664586,0.9808396,0.0005951921,0.0009005995,0.01517629],"study_design_scores_gemma":[0.0002996521,0.002437858,0.007065691,0.00004904173,0.0001123929,0.00177479,0.00004538323,0.000803871,0.9700028,0.0003352461,0.01705819,0.00001519026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973995,0.01158703,0.004654444,0.001766677,0.0002711216,0.00009599952,0.002122179,0.0003525482,0.00515502],"genre_scores_gemma":[0.9843464,0.004107097,0.002336362,0.0003729053,0.00008930545,0.0000775726,0.001576261,0.00003644958,0.007057713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004491433,"threshold_uncertainty_score":0.01502532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860249274182297,"score_gpt":0.2479683331457468,"score_spread":0.2193658404039239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}