{"id":"W102543571","doi":"10.4161/chan.3.1.7500","title":"Unexpected synergism between Tetrodotoxin and μ-conotoxin in blocking voltage-gated sodium channels","year":2009,"lang":"en","type":"article","venue":"Channels","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences","keywords":"Tetrodotoxin; Sodium channel; Chemistry; Neurotoxin; Biophysics; Conotoxin; Peptide; Xenopus; Binding site; Sodium channel blocker; Biochemistry; Sodium; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004386971,0.0004243705,0.000636136,0.0003096295,0.0001289552,0.00043068,0.0003555361,0.0004165392,0.001085062],"category_scores_gemma":[0.0003771472,0.0003465466,0.0003690991,0.00033328,0.0002566372,0.0005705019,0.0004491259,0.0005825681,0.0004359082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619295,"about_ca_system_score_gemma":0.0002528011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108257,"about_ca_topic_score_gemma":0.0002997929,"domain_scores_codex":[0.9994271,0.00009567643,0.00006432797,0.0001066356,0.0001779447,0.0001282738],"domain_scores_gemma":[0.9997216,0.00008654195,0.00005729355,0.00003790214,0.00003123802,0.00006543352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001515115,0.00001918182,0.0002615646,0.00004970377,0.00001525954,0.0001161273,0.000008471607,0.00005672398,0.9969698,0.0001495646,0.00003086074,0.00217126],"study_design_scores_gemma":[0.00004951851,0.0008999413,0.008484835,0.00001096439,0.0001257916,0.00159298,0.00002276339,0.001750544,0.9835113,0.0002416305,0.003298267,0.00001149126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763455,0.009342622,0.00952548,0.000236141,0.0001191159,0.00006585839,0.0001517289,0.0002176997,0.003995936],"genre_scores_gemma":[0.9909962,0.002671196,0.004387555,0.0001501443,0.00006225173,0.00004171002,0.000155888,0.00003580111,0.001499312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085062,"threshold_uncertainty_score":0.003629923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304307173783331,"score_gpt":0.2605688881293264,"score_spread":0.2475258163914931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}