{"id":"W1029955853","doi":"10.1161/circ.120.suppl_18.s1115-a","title":"Abstract 5553: S100A1 Modulates Endothelial Nitric Oxide Availability by Co-ordinate Regulation of Nitric Oxide Synthase Phosphorylation and Gene Expression of Related Signaling Molecules","year":2009,"lang":"en","type":"article","venue":"Circulation","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Endothelial nitric oxide synthase; Nitric oxide; Nitric oxide synthase; Phosphorylation; Medicine; Cell biology; Signal transduction; Cell signaling; Gene expression; Nitric Oxide Synthase Type III; Gene; Pharmacology; Biochemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200125,0.0005938589,0.0003995891,0.0001914247,0.0001647539,0.0002844629,0.0002773836,0.000554533,0.007139868],"category_scores_gemma":[0.0001208589,0.0001583145,0.0003018392,0.0001717654,0.0002704263,0.000229021,0.0002552382,0.0007882693,0.002009618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072957,"about_ca_system_score_gemma":0.0001527683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003691746,"about_ca_topic_score_gemma":0.000371224,"domain_scores_codex":[0.9998631,0.00001937264,0.00001445602,0.00003462361,0.00003697553,0.00003152119],"domain_scores_gemma":[0.9998983,0.000011404,0.00003232962,0.000007897961,0.00001029588,0.00003984263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007215479,0.00008826909,0.0003575607,0.0001338808,0.00001383894,0.000132758,0.00001043843,0.00004647437,0.9948298,0.00006934904,0.0004351831,0.003160831],"study_design_scores_gemma":[0.000238184,0.001444205,0.04176451,0.00006250762,0.00009808035,0.001003749,0.00006741028,0.001589632,0.9450629,0.0002132838,0.008443359,0.0000120555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859737,0.005081149,0.002519746,0.0008313358,0.0003488539,0.00004531166,0.001320991,0.0002034824,0.003675341],"genre_scores_gemma":[0.9812695,0.002508526,0.001563685,0.000316535,0.0000982822,0.00009765585,0.00186697,0.00005099981,0.01222777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007139868,"threshold_uncertainty_score":0.02388519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00773311949293763,"score_gpt":0.2260648347073224,"score_spread":0.2183317152143848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}