{"id":"W1033002479","doi":"10.1177/1934578x1300801109","title":"Ecology- and Bioassay-Guided Drug Discovery for Treatments of Tropical Parasitic Disease: 5α,8α-Epidioxycholest-6-en-3β-ol Isolated from the Mollusk <i>Dolabrifera dolabrifera</i> Shows Significant Activity against <i>Leishmania donovani</i>","year":2013,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; McGill University; University of California, Santa Cruz; Fogarty International Center; Smithsonian Institution","keywords":"Bioassay; Amastigote; Biology; Drug discovery; Trypanosoma cruzi; Parasitic disease; Plasmodium falciparum; Malaria; Microbiology; Leishmania; Parasite hosting; Biochemistry; Ecology; Disease; Immunology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087217,0.000389354,0.0002240638,0.0004035542,0.0001261473,0.0002713103,0.0001617237,0.0001675981,0.0007433447],"category_scores_gemma":[0.0001048204,0.0001098135,0.0001693147,0.0002667163,0.0002931293,0.0001910074,0.0002144853,0.0002764819,0.0001943358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981636,"about_ca_system_score_gemma":0.0003761863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006670846,"about_ca_topic_score_gemma":0.001956787,"domain_scores_codex":[0.9999621,0.000008170901,0.000002687394,0.000008609518,0.000008463268,0.000009975344],"domain_scores_gemma":[0.999951,0.000006197084,0.00001694841,0.000003903348,0.00001211882,0.00000981605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001620323,0.0001116834,0.001469514,0.0001844546,0.00001408047,0.0001278584,0.00003474755,0.0004363375,0.9787481,0.000134358,0.00007437603,0.01850243],"study_design_scores_gemma":[0.0003579289,0.003877862,0.02696076,0.00004482848,0.00007256838,0.001516616,0.0001451471,0.001010345,0.9538445,0.0002514447,0.01189746,0.00002059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784887,0.01130425,0.005348591,0.0004198987,0.00001994532,0.0002230438,0.0006627364,0.00008561773,0.003447189],"genre_scores_gemma":[0.9835502,0.007229848,0.006313715,0.0001669415,0.00001576394,0.0000595312,0.0008739356,0.000007913797,0.001782223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007433447,"threshold_uncertainty_score":0.002486765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152310546854167,"score_gpt":0.3154161071975183,"score_spread":0.2838930017289767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}