{"id":"W1033002479","doi":"10.1177/1934578x1300801109","title":"Ecology- and Bioassay-Guided Drug Discovery for Treatments of Tropical Parasitic Disease: 5α,8α-Epidioxycholest-6-en-3β-ol Isolated from the Mollusk <i>Dolabrifera dolabrifera</i> Shows Significant Activity against <i>Leishmania donovani</i>","year":2013,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; McGill University; University of California, Santa Cruz; Fogarty International Center; Smithsonian Institution","keywords":"Bioassay; Amastigote; Biology; Drug discovery; Trypanosoma cruzi; Parasitic disease; Plasmodium falciparum; Malaria; Microbiology; Leishmania; Parasite hosting; Biochemistry; Ecology; Disease; Immunology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004989287,0.0004772673,0.0008774622,0.0001239041,0.0008901744,0.0002121852,0.001113714,0.0001317175,0.00001702431],"category_scores_gemma":[0.002378327,0.0003211031,0.0002735262,0.0004612735,0.001353839,0.0007246014,0.0005956261,0.001025772,0.00002541787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286935,"about_ca_system_score_gemma":0.0003178118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000945902,"about_ca_topic_score_gemma":0.0004587511,"domain_scores_codex":[0.9963786,0.0009279576,0.0007418008,0.0008190998,0.0005055445,0.0006269673],"domain_scores_gemma":[0.9925427,0.002856227,0.0003284268,0.003199138,0.0007880991,0.0002853615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001989792,0.004425427,0.3329053,0.0003857713,0.003060662,0.00001605566,0.001890212,0.00001409606,0.5797577,0.001112631,0.05141369,0.02302874],"study_design_scores_gemma":[0.003421905,0.0002767218,0.9791372,0.0001992535,0.000625367,0.00001282992,0.0002608641,0.001947517,0.01014416,0.0005995516,0.002959246,0.0004154248],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078022,0.00820351,0.00005876808,0.07823393,0.0001807833,0.004756093,0.0005342037,0.00009806456,0.0001325046],"genre_scores_gemma":[0.9897425,0.004252329,0.001925762,0.001161397,0.0002207221,0.001004794,0.0004150663,0.00006382207,0.001213595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6462319,"threshold_uncertainty_score":0.9999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152310546854167,"score_gpt":0.3154161071975183,"score_spread":0.2838930017289767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}