{"id":"W103407665","doi":"10.1200/jco.2014.32.4_suppl.79","title":"The molecular and pathway characterization of patients with metastatic castration resistant prostate cancer (mCRPC) refractory to therapy with abiraterone acetate or enzalutamide: Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Enzalutamide; Prostate cancer; Abiraterone acetate; Medicine; Comparative genomic hybridization; Prostate; Biopsy; Cancer research; Cancer; Liquid biopsy; Oncology; PTEN; Pathology; Androgen receptor; Internal medicine; Androgen deprivation therapy; Biology; Gene; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003696966,0.0002116334,0.000237842,0.0003324607,0.0002223608,0.0003400659,0.0001724984,0.0001832207,0.0008871738],"category_scores_gemma":[0.000545495,0.0001176299,0.0001869048,0.0002825015,0.0001632996,0.0001191215,0.0002073886,0.0001671839,0.0002315837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325376,"about_ca_system_score_gemma":0.0002640024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002884973,"about_ca_topic_score_gemma":0.005401256,"domain_scores_codex":[0.9998983,0.00001899689,0.000009670198,0.00003109295,0.00002567174,0.00001632114],"domain_scores_gemma":[0.999697,0.00006099262,0.00005416422,0.00002980537,0.00004963856,0.0001083855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004267182,0.0002602459,0.8990911,0.0001605786,0.0001097238,0.001538578,0.0004542702,0.0003454755,0.0528191,0.00004929582,0.000623165,0.04028134],"study_design_scores_gemma":[0.0001451299,0.001952322,0.9885477,0.00001216852,0.00008372102,0.003929412,0.0001848651,0.0005626883,0.003010758,0.00003489003,0.001527934,0.000008363869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984677,0.0004858,0.0002353302,0.00002548445,0.000002010743,0.0000374859,0.0005094424,0.000008642957,0.0002280731],"genre_scores_gemma":[0.9973442,0.0002653425,0.0007838959,0.00004150714,0.000006481098,0.00002419232,0.001282271,0.000004931072,0.0002471479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002884973,"threshold_uncertainty_score":0.005736411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05467196105636116,"score_gpt":0.3879471556691834,"score_spread":0.3332751946128222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}