{"id":"W103694265","doi":"10.1097/ppo.0b013e3181b9c506","title":"Tumor Shrinkage and Objective Response Rates","year":2009,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Clinical trial; Medicine; Surrogate endpoint; End point; Sample size determination; Clinical endpoint; Intensive care medicine; Oncology; Internal medicine; Computer science; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009416809,0.0008126147,0.003426214,0.004081104,0.0001218687,0.00131772,0.001139354,0.0009115087,0.004708882],"category_scores_gemma":[0.03039892,0.0003847505,0.001654323,0.004291758,0.001276282,0.001740447,0.0006894877,0.002111075,0.001306315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001363079,"about_ca_system_score_gemma":0.001304963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005857663,"about_ca_topic_score_gemma":0.0006572906,"domain_scores_codex":[0.9935916,0.002912546,0.0009454699,0.0005465957,0.001911629,0.0000922478],"domain_scores_gemma":[0.9784186,0.01668454,0.00317687,0.0003491499,0.001209759,0.0001610581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003814638,0.00004811558,0.001729802,0.02723087,0.0006716115,0.00005954949,0.00008135623,0.001791813,0.0003852559,0.01034804,0.01523975,0.9420324],"study_design_scores_gemma":[0.0005309301,0.001648949,0.03800657,0.05433267,0.004396292,0.007089804,0.0003277926,0.003269277,0.003768858,0.05107157,0.8353314,0.0002258996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002920746,0.9961319,0.001210123,0.0004348995,0.0001532229,0.00002360701,0.00005563773,0.00001234632,0.001686154],"genre_scores_gemma":[0.008682986,0.9882118,0.001226327,0.0003863411,0.0005456812,0.0001130124,0.00008777207,0.0000138199,0.0007322411],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009416809,"threshold_uncertainty_score":0.04980141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6401582648585327,"score_gpt":0.6455445852726251,"score_spread":0.005386320414092483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}