{"id":"W1037174936","doi":"10.1371/journal.pone.0133800","title":"Type III Interferon Induces Distinct SOCS1 Expression Pattern that Contributes to Delayed but Prolonged Activation of Jak/STAT Signaling Pathway: Implications for Treatment Non-Response in HCV Patients","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Suppressor of cytokine signaling 1; Janus kinase; STAT1; STAT protein; Interferon; JAK-STAT signaling pathway; Biology; Signal transduction; stat; Cytokine; STAT3; Cancer research; Immunology; Molecular biology; Cell biology; Gene; Suppressor; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009772454,0.0001479028,0.0001602442,0.000126079,0.00009536707,0.0002118498,0.00004241284,0.000108174,0.001822687],"category_scores_gemma":[0.0001004252,0.00006344815,0.0002225973,0.00007294019,0.0001204916,0.00008027794,0.00008333377,0.0002784841,0.0002294179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001939088,"about_ca_system_score_gemma":0.0001330927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002240044,"about_ca_topic_score_gemma":0.0004073941,"domain_scores_codex":[0.9999275,0.000012148,0.000007665038,0.00001168462,0.00001268198,0.00002837805],"domain_scores_gemma":[0.999943,0.000006924271,0.00001879263,0.000004867245,0.000007345964,0.00001894646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001130662,0.00006318249,0.004719713,0.00009115423,0.00001256927,0.0001528483,0.00004496172,0.00007601345,0.9860684,0.0001281658,0.0001897107,0.007322486],"study_design_scores_gemma":[0.0001998671,0.003724742,0.2653707,0.00004988996,0.0001442322,0.003050387,0.0002639965,0.002253515,0.7139733,0.0003722169,0.01056729,0.00002984406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950655,0.002338112,0.0009582185,0.00009869309,0.00004307797,0.00002442073,0.0002787662,0.00003820845,0.001154981],"genre_scores_gemma":[0.997747,0.0005637982,0.0003613911,0.0000737841,0.000017722,0.00002017272,0.0003330021,0.000007278424,0.0008758237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822687,"threshold_uncertainty_score":0.006097496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1685212153441489,"score_gpt":0.3472254814723033,"score_spread":0.1787042661281544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}