{"id":"W1040070100","doi":"10.1021/acsmedchemlett.5b00196","title":"Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Prodrug; DNA gyrase; Chemistry; Pharmacology; Topoisomerase; Drug; Topoisomerase IV; Dosing; DNA; Combinatorial chemistry; Biochemistry; Medicine; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430827,0.0001135667,0.0002020348,0.00001720137,0.00001260444,0.000006901984,0.00005652196,0.00007351123,0.000005013947],"category_scores_gemma":[0.00001774172,0.00009252365,0.00002690251,0.0000298944,0.0001667575,0.00001068194,0.0000768293,0.00004563358,5.796624e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008036985,"about_ca_system_score_gemma":0.00005207158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002710755,"about_ca_topic_score_gemma":0.000001720593,"domain_scores_codex":[0.9992865,0.00001499614,0.0002414364,0.0001893244,0.0001442406,0.0001234736],"domain_scores_gemma":[0.9995623,0.000004949805,0.0001354749,0.0001586838,0.00006467787,0.00007396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004516384,0.00004408102,0.0001629326,0.0002347803,0.00004374951,0.000002911326,0.0004245623,3.411864e-7,0.9982052,0.000003758877,0.00005176754,0.0003742639],"study_design_scores_gemma":[0.001250203,0.0001808386,0.0001011138,0.0000565524,0.00004575403,0.00002410727,0.0001648056,0.000004047453,0.9972548,0.0000114839,0.0008103137,0.00009601458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990507,0.0001147044,0.0001135033,0.0004275344,0.0001330104,0.0001002335,0.00004091474,0.000002272239,0.00001708867],"genre_scores_gemma":[0.9991417,0.00007760388,0.0000459546,0.0001393176,0.0002628538,0.000006900712,0.0002511998,0.00001141093,0.00006308754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009504471,"threshold_uncertainty_score":0.3773005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00885759102294724,"score_gpt":0.2161473159802281,"score_spread":0.2072897249572808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}