{"id":"W1040760625","doi":"10.1007/bf03256275","title":"Molecular-Targeted Therapy for Duchenne Muscular Dystrophy","year":2008,"lang":"en","type":"review","venue":"Molecular Diagnosis & Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"","keywords":"Duchenne muscular dystrophy; Genetic enhancement; Muscular dystrophy; Medicine; Dystrophin; Gene delivery; Disease; Bioinformatics; Exon skipping; Zinc finger nuclease; Genome editing; Biology; Gene; Genetics; Internal medicine; Exon; CRISPR; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.000575642,0.001944011,0.00266527,0.0005577517,0.0003838341,0.0001862286,0.002126936,0.001584229,0.0001507095],"category_scores_gemma":[0.0001832266,0.001755544,0.00392652,0.0008681621,0.0003763388,0.00001428419,0.0002538188,0.0007510447,0.00009445955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725062,"about_ca_system_score_gemma":0.001038658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000297144,"about_ca_topic_score_gemma":0.00001128935,"domain_scores_codex":[0.9923522,0.001195793,0.001274984,0.002486704,0.0009636579,0.001726678],"domain_scores_gemma":[0.9951145,0.0001604024,0.0006335145,0.003010795,0.0005528157,0.000527947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001257228,0.000923974,0.000008670125,0.0007850487,0.003674303,0.0002207836,0.00004100407,0.00006730262,0.04454089,0.0000354681,0.005237036,0.9432083],"study_design_scores_gemma":[0.002930226,0.005560824,0.000004219474,0.0005768718,0.0001723642,0.00007127401,0.000005552357,0.000004266331,0.1181342,0.00006479793,0.8708548,0.00162059],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02408694,0.967433,0.0009564292,0.0001655814,0.0003772543,0.006390081,0.0004052223,0.0001232642,0.00006221366],"genre_scores_gemma":[0.0009864981,0.9807727,0.0008105581,0.001442865,0.0006845794,0.01106525,0.003198114,0.0009074758,0.0001319485],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9415877,"threshold_uncertainty_score":0.9997119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03652345605317493,"score_gpt":0.3386475188846578,"score_spread":0.3021240628314829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}