{"id":"W1043653796","doi":"10.1016/j.jalz.2015.05.015","title":"Genetically predicted body mass index and Alzheimer's disease–related phenotypes in three large samples: Mendelian randomization analyses","year":2015,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute on Aging; University of California, Irvine; Stichting MS Research; Canadian Institutes of Health Research; University of Washington; University of California, Los Angeles; National Institutes of Health; National Cancer Institute; National Center for Research Resources; U.S. Department of Defense; University of Alabama at Birmingham; BRACE; Universitat de Barcelona; Rush University; National Institute of Mental Health; University of Arizona; National Association for Colitis and Crohn's Disease; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; University of Pittsburgh; University of California, San Diego; Johns Hopkins University; Boston University; University of Miami; Northwestern University; Newcastle University; New York University; University of Kentucky; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; GlaxoSmithKline; Mayo Clinic; University of California, San Francisco; Indiana University; Vanderbilt University; University of Michigan; Wellcome Trust; Duke University; University of Southern California; University of California, Davis; Howard Hughes Medical Institute; Columbia University; Massachusetts General Hospital; Alzheimer's Research Trust","keywords":"Mendelian randomization; Confounding; Body mass index; Odds ratio; Confidence interval; Medicine; Disease; Demography; Dementia; Internal medicine; Genetics; Gerontology; Biology; Genotype; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0350191,0.001494257,0.001522085,0.00194124,0.00111672,0.001246928,0.001501614,0.001476699,0.001411963],"category_scores_gemma":[0.07013571,0.0007434368,0.003889903,0.001912447,0.001561059,0.0004836994,0.001277154,0.0009662373,0.0001877206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007544128,"about_ca_system_score_gemma":0.0009181543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005855646,"about_ca_topic_score_gemma":0.004544964,"domain_scores_codex":[0.9502914,0.04017656,0.001890851,0.004687245,0.00213708,0.000816833],"domain_scores_gemma":[0.9538284,0.02883142,0.004872482,0.01047571,0.001258678,0.000733284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02389389,0.0005746361,0.9218912,0.0001829752,0.02088695,0.001571899,0.0007663097,0.005075931,0.005581956,0.00277015,0.0009194975,0.01588449],"study_design_scores_gemma":[0.008097709,0.004525424,0.9022194,0.0001040345,0.01900449,0.003300528,0.0003555289,0.04754495,0.003951014,0.008385242,0.002247921,0.0002637175],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829053,0.0006852318,0.01500155,0.0001019159,0.00003721441,0.0002629347,0.0005877356,0.0001027631,0.0003153339],"genre_scores_gemma":[0.9900034,0.0001157156,0.008694734,0.0000695739,0.00002121975,0.0002914138,0.0006091106,0.00004376812,0.0001510424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0350191,"threshold_uncertainty_score":0.1852009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426240681183264,"score_gpt":0.2984775662804554,"score_spread":0.2642151594686228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}