{"id":"W1061343171","doi":"10.1021/acs.molpharmaceut.5b00131","title":"Agitation Rate and Time for Complete Dissolution in BCS Biowaivers Based on Investigation of a BCS Biowaiver for Dexketoprofen Tablets","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Dissolution; Bioequivalence; Dissolution testing; Chromatography; Cmax; Active ingredient; Chemistry; Dosage form; Mathematics; Materials science; Pharmacology; Medicine; Organic chemistry; Bioavailability; Biopharmaceutics Classification System","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001902111,0.0002510067,0.0003389544,0.0002603372,0.0001198997,0.00002382769,0.000161589,0.0002787067,0.00001304071],"category_scores_gemma":[0.0003326877,0.0002772864,0.0000985094,0.0002908676,0.0002386145,0.0001244393,0.00004127607,0.0002452077,0.00001694718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142449,"about_ca_system_score_gemma":0.0001709335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002121273,"about_ca_topic_score_gemma":0.000007671724,"domain_scores_codex":[0.9979193,0.0006400007,0.0004737967,0.0003755669,0.0001942657,0.0003971185],"domain_scores_gemma":[0.9983271,0.0005455012,0.0002616654,0.0001731106,0.0004287431,0.0002639237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005671929,0.0005000689,0.009426679,0.0009714032,0.0002687663,0.00002360344,0.00233706,0.06637815,0.8984586,0.003640682,0.008030473,0.004292567],"study_design_scores_gemma":[0.00952729,0.0006240857,0.0005815867,0.00007078382,0.0002332454,0.000003737387,0.0002040592,0.7847179,0.1684717,0.001835238,0.03334485,0.0003855073],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663544,0.0005004618,0.02531818,0.002106549,0.0008717169,0.003468184,0.000750767,0.00007433573,0.0005554277],"genre_scores_gemma":[0.9928839,0.00002409462,0.002481556,0.003723751,0.00007233734,0.0001880456,0.000451569,0.00003677272,0.0001379704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.729987,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1976964784650429,"score_gpt":0.4201248449830848,"score_spread":0.2224283665180419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}