{"id":"W1061343171","doi":"10.1021/acs.molpharmaceut.5b00131","title":"Agitation Rate and Time for Complete Dissolution in BCS Biowaivers Based on Investigation of a BCS Biowaiver for Dexketoprofen Tablets","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Dissolution; Bioequivalence; Dissolution testing; Chromatography; Cmax; Active ingredient; Chemistry; Dosage form; Mathematics; Materials science; Pharmacology; Medicine; Organic chemistry; Bioavailability; Biopharmaceutics Classification System","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001428818,0.0003630079,0.0004010744,0.0003607647,0.0001636155,0.0005187174,0.0003614644,0.0004658827,0.000888554],"category_scores_gemma":[0.004793704,0.0002045445,0.0003559196,0.000295727,0.000287275,0.0007177736,0.0002202161,0.0005480476,0.0002984953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004371504,"about_ca_system_score_gemma":0.0004724496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133388,"about_ca_topic_score_gemma":0.000949536,"domain_scores_codex":[0.9984855,0.0004335035,0.000250265,0.0001925887,0.0005495767,0.00008855948],"domain_scores_gemma":[0.9965702,0.001535608,0.001089754,0.0002211793,0.0004606028,0.0001226504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003078309,0.000283052,0.002796691,0.0003200374,0.00002366369,0.0001321085,0.0001627838,0.0007281271,0.9691278,0.0001858457,0.00009987054,0.0230618],"study_design_scores_gemma":[0.00004895988,0.007598257,0.0196095,0.00002937538,0.00007319509,0.0002600901,0.00009500657,0.003903685,0.9661378,0.00004991248,0.002156779,0.00003750349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864908,0.003958018,0.007476095,0.00008253041,0.00003535541,0.0002399404,0.0001491821,0.00005932215,0.001508729],"genre_scores_gemma":[0.9884812,0.001559146,0.008491225,0.00003316989,0.00001732081,0.0001151454,0.0002523077,0.00002240764,0.001028089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428818,"threshold_uncertainty_score":0.007556379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1976964784650429,"score_gpt":0.4201248449830848,"score_spread":0.2224283665180419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}