{"id":"W1062757972","doi":"10.1016/j.virusres.2015.07.015","title":"Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir","year":2015,"lang":"en","type":"article","venue":"Virus Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Centre for Disease Control; Centre for Drug Research and Development; University of British Columbia; Simon Fraser University","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control","keywords":"Oseltamivir; Neuraminidase; Neuraminidase inhibitor; Biology; Virology; Virus; Serial passage; Microbiology; Influenza A virus; Resistance mutation; Mutation; Drug resistance; Genetics; Gene; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003246023,0.0002552173,0.000355444,0.0001433119,0.0001316524,0.0001589463,0.0001717434,0.000274179,0.00203508],"category_scores_gemma":[0.0003260237,0.00007977291,0.0001467181,0.000100969,0.0001566293,0.0003079318,0.00009534197,0.0002437499,0.0003202934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001628337,"about_ca_system_score_gemma":0.0001918547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000677171,"about_ca_topic_score_gemma":0.001277814,"domain_scores_codex":[0.9998636,0.00003665825,0.00001422038,0.00002177014,0.00003463693,0.00002907075],"domain_scores_gemma":[0.9998031,0.00004866103,0.00006426674,0.00001896069,0.00002506243,0.0000399794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004259684,0.0001977495,0.001021571,0.0001055059,0.00003512911,0.000084947,0.00003080014,0.0001834703,0.9627365,0.0003500823,0.0003102693,0.03068426],"study_design_scores_gemma":[0.0004559542,0.01070061,0.008368941,0.00002061352,0.0000702032,0.001440682,0.00005436697,0.0005281399,0.9676346,0.0001351636,0.01057316,0.00001755896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904408,0.004895155,0.001342047,0.0001143747,0.00007959082,0.00003479895,0.0002116619,0.00003172511,0.002849894],"genre_scores_gemma":[0.9931979,0.001981559,0.001785904,0.00008140943,0.00004356864,0.00001484493,0.000358642,0.00001256269,0.002523606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203508,"threshold_uncertainty_score":0.006808043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1883267712799395,"score_gpt":0.4228213032289848,"score_spread":0.2344945319490453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}