{"id":"W106357471","doi":"10.4049/jimmunol.178.supp.88.26","title":"The inverse agonist activity of soluble CTLA-4 ligands requires oligomerization of this receptor and CD28 expression (88.26)","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"CD28; Receptor; Chemistry; Cell biology; T cell; Agonist; CTLA-4; Inverse agonist; T-cell receptor; Ligand (biochemistry); Biochemistry; Biology; In vitro; Cytotoxic T cell; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515031,0.0003506958,0.0001803663,0.0001271122,0.0001001729,0.0002919092,0.0001404209,0.0002482282,0.002887816],"category_scores_gemma":[0.0001494212,0.0001260064,0.0002983635,0.00007480327,0.0001440855,0.0001106808,0.0001873524,0.0006182654,0.001164654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003270101,"about_ca_system_score_gemma":0.0002433024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264949,"about_ca_topic_score_gemma":0.0004740687,"domain_scores_codex":[0.9997812,0.00004523589,0.00001770804,0.00003031236,0.00006679823,0.00005877235],"domain_scores_gemma":[0.9998901,0.00002775715,0.00002051334,0.00001754071,0.00001468242,0.00002939208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003099062,0.00001787411,0.00004617858,0.000009990713,0.000001717048,0.00001613378,0.000002618735,0.00002207377,0.9992874,0.00006161493,0.00001829272,0.0004852626],"study_design_scores_gemma":[0.00001903856,0.0002641508,0.002048984,0.000005968908,0.00001182011,0.0003840508,0.00001028331,0.0006386252,0.993996,0.00004338708,0.002574983,0.000002504763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912451,0.001070491,0.003213533,0.0001140467,0.00003103924,0.00003397294,0.0001942185,0.00006133334,0.004036224],"genre_scores_gemma":[0.9866997,0.0006707045,0.003870369,0.00008347219,0.00002151485,0.00005250106,0.001033521,0.00002159169,0.007546643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002887816,"threshold_uncertainty_score":0.009660721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552047556053295,"score_gpt":0.2751776953076833,"score_spread":0.2596572197471503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}