{"id":"W1071546559","doi":"10.1053/j.gastro.2015.07.061","title":"Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy","year":2015,"lang":"en","type":"review","venue":"Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":436,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University Health Network","funders":"Novartis; Innogenetics; Alberta Cancer Foundation; Canadian Institutes of Health Research; Intercept Pharmaceuticals; Meso Scale Diagnostics; Medical Research Council; Alberta Heritage Foundation for Medical Research; Ferring Pharmaceuticals; Canadian Liver Foundation; Ikaria; Janssen Pharmaceuticals; Gilead Sciences; Cilag; Medtronic; Takeda Pharmaceutical Company; AbbVie; Abbott Laboratories; Merck; GlaxoSmithKline; Stichting voor Lever- en Maag-Darm Onderzoek; Wellcome Trust; Roche; Astellas Pharma US","keywords":"Medicine; Hazard ratio; Ursodeoxycholic acid; Internal medicine; Confidence interval; Liver transplantation; Primary biliary cirrhosis; Gastroenterology; Proportional hazards model; Transplantation; Cohort; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295891,0.0002918579,0.00178056,0.000290092,0.00002804074,0.000005321564,0.0001441849,0.0001095192,0.000005274961],"category_scores_gemma":[0.00002596926,0.0001963051,0.000127798,0.0001260381,0.00005822434,0.00005965244,0.0001424941,0.0001585276,0.000001700594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957522,"about_ca_system_score_gemma":0.0002057594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000162569,"about_ca_topic_score_gemma":0.000001265538,"domain_scores_codex":[0.9982762,0.0001998015,0.0006905184,0.0003041777,0.0002860873,0.0002431603],"domain_scores_gemma":[0.9986659,0.00003253189,0.0005195452,0.0004007622,0.0002118043,0.0001694347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006222753,0.0002866158,0.7850313,0.01272565,0.0008560068,0.000002089577,0.0003266131,3.237171e-7,0.000002882597,5.325542e-7,0.00002376175,0.200122],"study_design_scores_gemma":[0.00261687,0.002286848,0.9686109,0.01255885,0.001156677,0.00002245719,0.00007144229,5.022546e-7,0.00001250482,2.197888e-7,0.01253154,0.0001311891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7917598,0.2067412,0.00004833346,0.000008847141,0.0001137699,0.001209422,0.00007415919,0.00002146805,0.00002298334],"genre_scores_gemma":[0.1789347,0.8132871,0.00588343,0.0002090908,0.0000796325,0.0003960811,0.001051756,0.0001314553,0.00002669867],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6128252,"threshold_uncertainty_score":0.8005088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03665530723577537,"score_gpt":0.2846474220221996,"score_spread":0.2479921147864242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}