{"id":"W1078633685","doi":"10.1016/j.gendis.2015.07.002","title":"For your eyes only: Harnessing human embryonic stem cell-derived retinal pigment epithelial cells to improve impaired vision","year":2015,"lang":"en","type":"article","venue":"Genes & Diseases","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Center for Complementary and Integrative Health; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Embryonic stem cell; Retinal pigment epithelium; Retinal; Stem cell; Biology; Macular degeneration; Retina; Pigment; Degeneration (medical); Retinal Disorder; Retinal degeneration; Cell biology; Neuroscience; Anatomy; Pathology; Ophthalmology; Medicine; Chemistry; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320686,0.0002673445,0.0002076067,0.00005491298,0.000204938,0.00009734812,0.0002429648,0.00009834034,0.00001030815],"category_scores_gemma":[0.00001936792,0.0002446699,0.0001726937,0.00006932545,0.00005194864,0.0000100546,0.0001823444,0.0000347195,0.00002489092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003869757,"about_ca_system_score_gemma":0.0003225008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001637639,"about_ca_topic_score_gemma":0.00001122511,"domain_scores_codex":[0.9985094,0.00005686209,0.000253412,0.0005439384,0.0002195578,0.0004168449],"domain_scores_gemma":[0.999039,0.00001008073,0.000114631,0.0003082222,0.0001594163,0.0003686739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006256641,0.0001578267,0.002170183,0.00007302339,0.00002993792,0.000003182422,0.0001321665,0.00007451911,0.9773806,0.000006637383,0.006510266,0.01283602],"study_design_scores_gemma":[0.002002829,0.001230933,0.007151868,0.00003696019,0.00009902611,0.000001818145,0.001257473,0.00005245834,0.9515668,0.0001114643,0.03594214,0.0005462306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944779,0.002404477,0.001536398,0.0002319629,0.000399213,0.0006288525,0.0001357971,0.00003610098,0.0001493516],"genre_scores_gemma":[0.9956727,0.00008769508,0.0009315411,0.0002450797,0.0003676799,0.0001186315,0.0003755832,0.00004617752,0.002154898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02943188,"threshold_uncertainty_score":0.997735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670214710246185,"score_gpt":0.2772021443503232,"score_spread":0.2604999972478613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}