{"id":"W1081615781","doi":"10.1016/j.bbagrm.2015.08.001","title":"Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"NRF1; Biochemistry; Endoplasmic reticulum; Biology; Cell biology; Citric acid cycle; Mitochondrion; Metabolism; Mitochondrial biogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001276104,0.0006962612,0.001378819,0.0008647488,0.00008140694,0.00005434447,0.000657726,0.0006624668,0.000009947073],"category_scores_gemma":[0.0001454056,0.0007296393,0.0003548004,0.0007479612,0.0001295413,0.00002692966,0.0008768433,0.0004041805,0.00001357991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192883,"about_ca_system_score_gemma":0.0005757138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002271632,"about_ca_topic_score_gemma":0.00002981418,"domain_scores_codex":[0.9953281,0.0008239168,0.0009771925,0.001510825,0.0006152732,0.000744745],"domain_scores_gemma":[0.9976701,0.00005449956,0.0005385175,0.001079786,0.0002338213,0.0004233385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651839,0.0001804722,7.794531e-8,0.000759653,0.0001134259,0.000004052465,0.0002262732,0.000008547482,0.9733355,0.0007957484,0.0000411067,0.02436995],"study_design_scores_gemma":[0.0006201499,0.0003719559,0.00011432,0.002910506,0.0001905435,0.000002730412,0.0001639137,0.00005054518,0.9696023,0.02327748,0.001941449,0.0007541431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6865314,0.3092138,0.0008133525,0.00006271045,0.0002021831,0.002464404,0.0006482605,0.00002449815,0.00003943987],"genre_scores_gemma":[0.5272284,0.46335,0.004473232,0.00006480388,0.0005183221,0.0006016614,0.003189327,0.0002771129,0.0002971464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1593029,"threshold_uncertainty_score":0.9995155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05297365798885936,"score_gpt":0.3423265324245442,"score_spread":0.2893528744356849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}