{"id":"W1083409746","doi":"10.1097/qad.0000000000000752","title":"The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B","year":2015,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Integrase; Elvitegravir; Virology; Raltegravir; Integrase inhibitor; Biology; Viral replication; Virus; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374371,0.0006207624,0.0004262971,0.0002102934,0.00031618,0.0005566772,0.0004799314,0.0006663063,0.003609012],"category_scores_gemma":[0.0003900422,0.0001802494,0.0005192818,0.0002528505,0.0004289326,0.0002072073,0.0002042016,0.0008066795,0.001155741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003883824,"about_ca_system_score_gemma":0.0004798389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001658987,"about_ca_topic_score_gemma":0.001487141,"domain_scores_codex":[0.9995868,0.0000812211,0.00005410012,0.00008746089,0.0001301791,0.00006030437],"domain_scores_gemma":[0.9996142,0.00006217319,0.0001987807,0.00004495861,0.00003620942,0.00004361471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004157492,0.00008810077,0.003200935,0.0000717337,0.00004940577,0.0004487779,0.00002713121,0.0003735916,0.9921017,0.0001829661,0.00008045508,0.002959464],"study_design_scores_gemma":[0.0001567224,0.00164289,0.03323729,0.00006426969,0.0001462146,0.009062342,0.0001474274,0.003322295,0.9459087,0.0002365984,0.006013312,0.00006189214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957377,0.0006317801,0.001513795,0.000109937,0.00002928711,0.00002983079,0.000363328,0.00004444745,0.001539856],"genre_scores_gemma":[0.9953466,0.0003474435,0.002555446,0.0001367859,0.00001501203,0.00001544029,0.0005230149,0.00004879354,0.001011447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003609012,"threshold_uncertainty_score":0.01207334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563378964854876,"score_gpt":0.2861205282047034,"score_spread":0.2604867385561547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}