{"id":"W1083409746","doi":"10.1097/qad.0000000000000752","title":"The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B","year":2015,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Integrase; Elvitegravir; Virology; Raltegravir; Integrase inhibitor; Biology; Viral replication; Virus; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004271857,0.0001084765,0.0001520771,0.0001158235,0.00005205939,0.00002018091,0.00003965107,0.00006418752,0.000005504377],"category_scores_gemma":[0.0001980532,0.00007320041,0.0000275802,0.0001964931,0.00004925998,0.00009523303,0.00001576892,0.00008290576,0.00002792317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878866,"about_ca_system_score_gemma":0.0001043849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008394534,"about_ca_topic_score_gemma":0.0001548327,"domain_scores_codex":[0.9992383,0.00003036407,0.0002247391,0.0002203017,0.0001245299,0.0001617271],"domain_scores_gemma":[0.9995062,0.00005888732,0.00005612754,0.0002494628,0.00006435929,0.0000649803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001318972,0.0002036043,0.9632026,0.00007185529,0.00006677675,0.00001518383,0.003299995,0.000002937386,0.0008280464,0.003479778,0.003197259,0.02431301],"study_design_scores_gemma":[0.01505077,0.001772514,0.9290235,0.0004745275,0.0003508388,0.00008216508,0.004124341,0.006963059,0.008456931,0.009177841,0.02400636,0.0005171683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947999,0.0005198512,0.0007284188,0.002986467,0.00009513827,0.0006469779,0.000003526033,0.00002609281,0.000193697],"genre_scores_gemma":[0.997196,0.00007099283,0.000791383,0.0001616198,0.00003769876,0.0001700313,0.000123263,0.00001113717,0.001437926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03417911,"threshold_uncertainty_score":0.2985026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563378964854876,"score_gpt":0.2861205282047034,"score_spread":0.2604867385561547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}