{"id":"W108879930","doi":"10.1096/fasebj.23.1_supplement.850.6","title":"The Hace1 E3 ligase: linking misfolded protein load and oncogenesis","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Cell biology; Ubiquitin ligase; Chemistry; Proteostasis; Proteasome; Ubiquitin; Carcinogenesis; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590708,0.0003134497,0.0002027566,0.0004048939,0.0001784164,0.0003473099,0.0002315409,0.0004829791,0.00132759],"category_scores_gemma":[0.0001424393,0.0001361737,0.0001515492,0.0002012182,0.0003293046,0.0004540146,0.000241297,0.0005049882,0.0003049454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007326182,"about_ca_system_score_gemma":0.0002233414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006073944,"about_ca_topic_score_gemma":0.0005007922,"domain_scores_codex":[0.9999152,0.00001237934,0.000006331046,0.00001963839,0.00002426926,0.00002206619],"domain_scores_gemma":[0.9999406,0.000009477376,0.00001799511,0.000006380054,0.00000827133,0.00001733419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003714743,0.00005500411,0.001063598,0.0001218331,0.00001621007,0.0003522158,0.00001912368,0.0003502523,0.9879755,0.001370631,0.0003270086,0.007977006],"study_design_scores_gemma":[0.00002085552,0.0000958454,0.00406654,0.000004609749,0.00001052149,0.001119593,0.00001333186,0.00125452,0.9887373,0.0003300902,0.004342002,0.000004640041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713973,0.01441488,0.008514286,0.0009876352,0.00007127908,0.00004996486,0.0005261484,0.0002122076,0.003826237],"genre_scores_gemma":[0.9895697,0.003215312,0.002256588,0.0001026118,0.00001516647,0.00002078107,0.0004127605,0.00001896458,0.004388057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132759,"threshold_uncertainty_score":0.005315542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084345106406475,"score_gpt":0.2584193904968127,"score_spread":0.247575939432748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}