{"id":"W1098269449","doi":"10.1096/fj.14-267328","title":"The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors","year":2015,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Spermatogenesis; Demethylase; Progenitor cell; Conditional gene knockout; Epigenetics; Transcriptome; Progenitor; H3K4me3; Cell biology; Stem cell; Histone; Genetics; Gene; Gene expression; Phenotype; Endocrinology; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378339,0.0002184057,0.0002413978,0.0002635427,0.0003194152,0.0003966777,0.0002462397,0.000243286,0.001092458],"category_scores_gemma":[0.0002096373,0.0002470908,0.0002222911,0.0001660397,0.0002366513,0.0001917058,0.0003069557,0.0003306425,0.0006483961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003065063,"about_ca_system_score_gemma":0.0003221861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008313974,"about_ca_topic_score_gemma":0.00176681,"domain_scores_codex":[0.9998176,0.00001472572,0.00002060162,0.00006167043,0.00006046839,0.00002501981],"domain_scores_gemma":[0.9997543,0.00002256392,0.0001135012,0.00002625177,0.00002805293,0.00005544309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004960114,0.000005739012,0.00110124,0.00005469614,0.000005530007,0.00003922348,0.00001051663,0.00004581991,0.9958208,0.00008820496,0.00006203165,0.002716562],"study_design_scores_gemma":[0.00001876354,0.0001504325,0.08510739,0.000028622,0.00003619879,0.0007058324,0.00006282226,0.001373751,0.8977017,0.0002165154,0.01458349,0.00001454358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745504,0.01195658,0.008744556,0.0002467149,0.00006454191,0.00002799065,0.001993879,0.0003422848,0.002073031],"genre_scores_gemma":[0.9894938,0.002447371,0.003461819,0.00007830682,0.00001388835,0.0000198795,0.001414426,0.00004713545,0.003023316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092458,"threshold_uncertainty_score":0.003654659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138321742574498,"score_gpt":0.2618273236043548,"score_spread":0.2404441061786099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}