{"id":"W1125187349","doi":"10.1007/978-3-319-16009-2_5","title":"Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates","year":2015,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Hydroxylation; Monooxygenase; Regioselectivity; CYP2B6; Cytochrome P450; Substrate (aquarium); Enzyme; Stereochemistry; Organic chemistry; Biochemistry; Catalysis; CYP1A2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005287079,0.0008520156,0.000927415,0.0009680705,0.0001920172,0.0005750527,0.0007313235,0.0004970602,0.003019598],"category_scores_gemma":[0.0003355072,0.0003558506,0.000655666,0.001171997,0.0003554539,0.0009728521,0.0006524449,0.001192971,0.002010343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404124,"about_ca_system_score_gemma":0.0002598381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002520653,"about_ca_topic_score_gemma":0.0006947546,"domain_scores_codex":[0.99981,0.00003368891,0.00001882393,0.00005528661,0.00004970116,0.00003244546],"domain_scores_gemma":[0.9999083,0.00003672204,0.00001878557,0.00001073276,0.00001720418,0.000008235816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003557224,0.0002800836,0.0007586572,0.0125345,0.0003109677,0.001416715,0.0001886913,0.001848656,0.08596369,0.01391144,0.01424735,0.8681836],"study_design_scores_gemma":[0.0000991621,0.001055578,0.00274011,0.000833323,0.0004217314,0.006747323,0.0001102694,0.00105709,0.1092298,0.007441315,0.8701428,0.0001215839],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01622972,0.9607096,0.007312844,0.0004753563,0.0003955815,0.00005508215,0.0003348278,0.0001262232,0.01436066],"genre_scores_gemma":[0.06919193,0.9160003,0.005783281,0.0003774631,0.00037508,0.0000706069,0.0003903598,0.00002906505,0.007781829],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003019598,"threshold_uncertainty_score":0.01010156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2506256391629043,"score_gpt":0.5149566931814417,"score_spread":0.2643310540185373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}