{"id":"W1126563899","doi":"10.2967/jnumed.115.155002","title":"Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; Abramson Cancer Center; National Center for Research Resources; Tobacco-Related Disease Research Program; University of Pennsylvania; National Institute on Drug Abuse; Perelman School of Medicine, University of Pennsylvania; Office of Research and Development; Pennsylvania Department of Health; Pfizer; Institute for Translational Medicine and Therapeutics; U.S. Department of Veterans Affairs","keywords":"Nicotine; Chemistry; Nicotinic agonist; CYP2A6; Nicotinic acetylcholine receptor; Pharmacology; Abstinence; Cotinine; Acetylcholine receptor; Metabolite; Metabolism; Internal medicine; Receptor; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003318691,0.0002769492,0.0003115382,0.0004287208,0.0002185154,0.0003396682,0.000204874,0.0003148672,0.002005292],"category_scores_gemma":[0.0007354989,0.0002022661,0.0001477973,0.0002110506,0.0002838769,0.0001996998,0.0002197995,0.000236257,0.0001980138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511275,"about_ca_system_score_gemma":0.00009373312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271182,"about_ca_topic_score_gemma":0.001928121,"domain_scores_codex":[0.9999138,0.00002055519,0.000009880395,0.00002027588,0.00002179714,0.00001368137],"domain_scores_gemma":[0.9996706,0.0000579926,0.0001565292,0.00002767362,0.00004307162,0.00004422198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00198539,0.0001344835,0.9406883,0.0000326045,0.00009870782,0.0004695551,0.0001818337,0.00007402695,0.04664836,0.00002607567,0.00005607813,0.009604434],"study_design_scores_gemma":[0.00001171494,0.0003483492,0.9959809,0.000002313715,0.00004210351,0.0009604116,0.00008749455,0.0002099968,0.002246669,0.00002080619,0.00008688266,0.000002280951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995908,0.0001484867,0.00008748669,0.000009948065,0.000001132115,0.00000406557,0.00002728768,0.000004698932,0.0001260148],"genre_scores_gemma":[0.9996033,0.00007505948,0.0001178009,0.000009822318,0.000002880816,0.000003537792,0.00004254975,0.000001844225,0.0001431889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005292,"threshold_uncertainty_score":0.006708324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269891095842511,"score_gpt":0.2880931921825385,"score_spread":0.2653942812241133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}