{"id":"W1126563899","doi":"10.2967/jnumed.115.155002","title":"Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; Abramson Cancer Center; National Center for Research Resources; Tobacco-Related Disease Research Program; University of Pennsylvania; National Institute on Drug Abuse; Perelman School of Medicine, University of Pennsylvania; Office of Research and Development; Pennsylvania Department of Health; Pfizer; Institute for Translational Medicine and Therapeutics; U.S. Department of Veterans Affairs","keywords":"Nicotine; Chemistry; Nicotinic agonist; CYP2A6; Nicotinic acetylcholine receptor; Pharmacology; Abstinence; Cotinine; Acetylcholine receptor; Metabolite; Metabolism; Internal medicine; Receptor; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001774487,0.0002102649,0.000671264,0.0001473264,0.00001971843,0.000005126029,0.0003550259,0.0001338396,0.0002215615],"category_scores_gemma":[0.001692718,0.0001412878,0.0001093593,0.0002918765,0.000303841,0.00001310575,0.00008340078,0.0003188011,0.000008135836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004719822,"about_ca_system_score_gemma":0.0003052325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006514443,"about_ca_topic_score_gemma":0.00003007792,"domain_scores_codex":[0.9978879,0.0002305019,0.0009143184,0.0002364921,0.0004826216,0.0002481365],"domain_scores_gemma":[0.9979256,0.00005704565,0.0007549786,0.0003667368,0.0005929576,0.0003026761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007787392,0.001680047,0.1512255,0.0001331513,0.0006761713,0.000008507909,0.001862802,0.0001631333,0.7095107,0.00008009892,0.1237339,0.003138597],"study_design_scores_gemma":[0.05588744,0.02103518,0.07224754,0.001440553,0.0007668795,0.0005537267,0.01266782,0.0001704975,0.2642216,0.0001195922,0.5697235,0.001165677],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994161,0.002946289,0.00003268457,0.00148687,0.0003593331,0.000172915,0.00000387056,0.000004900241,0.0008321207],"genre_scores_gemma":[0.9961128,0.000491348,0.002364655,0.0002666904,0.0005801896,0.000001280721,0.000007436019,0.00004149792,0.0001341406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4459896,"threshold_uncertainty_score":0.5761549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269891095842511,"score_gpt":0.2880931921825385,"score_spread":0.2653942812241133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}