{"id":"W1127933869","doi":"10.1097/cji.0000000000000089","title":"Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents","year":2015,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Clinical trial; Oncology; Drug development; Cancer; Chemotherapy; Disease; Immunotherapy; Drug; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00301575,0.0001815969,0.0008547778,0.0002875505,0.00003011792,0.00002474839,0.0001449865,0.0001634466,0.0007798671],"category_scores_gemma":[0.0003321962,0.0001396538,0.0003019708,0.0002544994,0.0002485829,0.0001356815,0.00001044176,0.0004286355,0.000004202064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364359,"about_ca_system_score_gemma":0.001834362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001286248,"about_ca_topic_score_gemma":0.000009255297,"domain_scores_codex":[0.9964228,0.0005091588,0.002153558,0.000151873,0.0005304738,0.0002321534],"domain_scores_gemma":[0.9976811,0.0005525509,0.0008986549,0.0002807444,0.0004556126,0.0001313286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8062202,0.003639129,0.02853157,0.00005128932,0.003051231,0.0003006702,0.002938926,0.0004152057,0.03561335,0.0002337717,0.01406568,0.1049389],"study_design_scores_gemma":[0.7433259,0.0346708,0.1829468,0.001372572,0.0004732083,0.0009437568,0.001067881,0.0006177208,0.007243648,0.00304973,0.023614,0.0006740187],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585943,0.02152022,0.01383082,0.002158785,0.002513417,0.001152468,0.00002049658,0.00001453803,0.0001949962],"genre_scores_gemma":[0.9819757,0.006272272,0.009297997,0.001828355,0.0004027941,0.00001925809,0.000002233787,0.00004339065,0.0001580497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1544152,"threshold_uncertainty_score":0.8538997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2369880089025636,"score_gpt":0.4567935504305351,"score_spread":0.2198055415279715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}