{"id":"W1127933869","doi":"10.1097/cji.0000000000000089","title":"Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents","year":2015,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Clinical trial; Oncology; Drug development; Cancer; Chemotherapy; Disease; Immunotherapy; Drug; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.5990449,0.002455135,0.009672779,0.004652958,0.002467166,0.006692074,0.00502196,0.007165142,0.0083863],"category_scores_gemma":[0.7096819,0.002317569,0.006449438,0.008917159,0.009677283,0.006408771,0.004504004,0.01371716,0.001946612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004434628,"about_ca_system_score_gemma":0.00761524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009325885,"about_ca_topic_score_gemma":0.00122302,"domain_scores_codex":[0.1682175,0.7739528,0.02483907,0.008676295,0.02249832,0.001816019],"domain_scores_gemma":[0.2823456,0.6260815,0.02208201,0.05016364,0.01558283,0.00374439],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.1469065,0.001915509,0.02752743,0.02655607,0.02915529,0.002986882,0.005009783,0.05413063,0.004714259,0.2037088,0.05908877,0.4383001],"study_design_scores_gemma":[0.03090828,0.03424501,0.02179554,0.008549755,0.008496271,0.0014963,0.001545426,0.3155164,0.009268908,0.3486874,0.2188531,0.0006376015],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03113245,0.01867197,0.7879159,0.01648869,0.01853149,0.1045916,0.002024464,0.002208148,0.01843516],"genre_scores_gemma":[0.2504071,0.002119711,0.5394667,0.00939649,0.00269455,0.1907819,0.0006689203,0.0006174091,0.003847067],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5990449,"threshold_uncertainty_score":0.494449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2369880089025636,"score_gpt":0.4567935504305351,"score_spread":0.2198055415279715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}