{"id":"W1128533856","doi":"10.1016/j.bmc.2015.07.019","title":"A-ring substituted 17β-arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent reversible inhibitors of steroid sulfatase","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Steroid sulfatase; Steroid; Ring (chemistry); Stereochemistry; Biochemistry; Organic chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717235,0.0004257953,0.0002592724,0.0002693931,0.0001634206,0.000172475,0.0004702644,0.0002338188,0.002612371],"category_scores_gemma":[0.0001507506,0.0001649877,0.0001656253,0.0001910236,0.000252429,0.0002551735,0.0002389902,0.0003766605,0.0006271964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002875249,"about_ca_system_score_gemma":0.000269784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006552197,"about_ca_topic_score_gemma":0.001671419,"domain_scores_codex":[0.9999096,0.00001957818,0.000006594602,0.00001055376,0.00002138734,0.00003237089],"domain_scores_gemma":[0.9999291,0.00001539196,0.00001886376,0.000007470528,0.000007739864,0.00002143693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001042875,0.0002886088,0.000355236,0.0003397379,0.00003981968,0.0006423846,0.000208054,0.001751657,0.9625402,0.004980855,0.001269836,0.02654068],"study_design_scores_gemma":[0.0003083709,0.004074868,0.002269946,0.00002609363,0.00004561503,0.0007474814,0.00007851067,0.001956428,0.9659357,0.0003616889,0.02416229,0.00003302567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611788,0.009054232,0.00548269,0.000213779,0.0002312885,0.0001382047,0.0005570645,0.0003262923,0.02281764],"genre_scores_gemma":[0.9852946,0.005578837,0.001940715,0.0000968344,0.00005103793,0.0000565266,0.0003015009,0.00002136289,0.006658471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002612371,"threshold_uncertainty_score":0.008739293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173105456988621,"score_gpt":0.2331474225771486,"score_spread":0.2214163680072624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}