{"id":"W1141087116","doi":"10.1016/j.bbadis.2015.08.010","title":"Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":446,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Sepsis; Inflammation; Medicine; Exosome; Immunology; Microvesicles; Blockade; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002556961,0.0003080966,0.0002788888,0.000083637,0.00007602141,0.00004451407,0.0002821902,0.0001281505,0.000002636526],"category_scores_gemma":[0.000182768,0.0002478433,0.0002049748,0.000221229,0.0002582319,0.00002825997,0.0001776039,0.0001055282,0.000002357108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002250683,"about_ca_system_score_gemma":0.0003012534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001888068,"about_ca_topic_score_gemma":0.000003126757,"domain_scores_codex":[0.9980848,0.0003069327,0.0003803723,0.0005246093,0.0004664261,0.0002368251],"domain_scores_gemma":[0.9980804,0.00001997167,0.0003647255,0.0009153095,0.0003015894,0.0003179867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005503403,0.0001780906,0.00014863,0.00006941228,0.0002362459,0.000004064236,0.0001071771,0.0001225565,0.9978305,0.0002112312,0.0001896155,0.0003522059],"study_design_scores_gemma":[0.0008356398,0.0003990634,0.006232,0.00003612204,0.0004268474,0.000001552505,0.0001134977,0.0003280351,0.9911374,0.0001072021,0.00009077006,0.0002918192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971431,0.0006222204,0.0003689459,0.0009464615,0.00009035904,0.0005682802,0.0001407703,0.00001945691,0.00010037],"genre_scores_gemma":[0.9984171,0.00009220177,0.0004859911,0.00009482202,0.0002220712,0.00006291429,0.000541923,0.00005382602,0.00002919874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00669298,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571496560811526,"score_gpt":0.2405109096794871,"score_spread":0.2247959440713718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}