{"id":"W114834912","doi":"10.1096/fasebj.22.1_supplement.710.7","title":"Decline in NRF2‐Regulated Antioxidant Pathway in Advanced COPD Patient Lungs Due to DJ‐1 Deficit","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GCLM; COPD; Oxidative stress; KEAP1; Gene knockdown; Inflammation; Medicine; Glutathione; Lung; Antioxidant; Lipid peroxidation; Curcumin; Immunology; Pathology; Chemistry; GCLC; Pharmacology; Internal medicine; Transcription factor; Biochemistry; Apoptosis; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371608,0.0002306868,0.0003842063,0.000332707,0.0002094447,0.0002016792,0.0001130754,0.0002725792,0.001706066],"category_scores_gemma":[0.0001459327,0.0001106428,0.0002576539,0.0001595155,0.0002595524,0.0002045362,0.0001950399,0.000431707,0.0002017595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684433,"about_ca_system_score_gemma":0.0001210737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685932,"about_ca_topic_score_gemma":0.0003645786,"domain_scores_codex":[0.9999352,0.000008594412,0.000007128076,0.00002237594,0.00001507469,0.00001173029],"domain_scores_gemma":[0.9999048,0.000009419153,0.00002585261,0.000005568712,0.00001124778,0.00004317372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001061746,0.0001179602,0.005564886,0.00008639027,0.00002964259,0.0007418082,0.00004495824,0.00004527461,0.9893952,0.00007601807,0.00009279361,0.002743356],"study_design_scores_gemma":[0.0002159933,0.002291165,0.3878469,0.00002285064,0.0002242008,0.01099905,0.000361203,0.00250998,0.5895112,0.0006147411,0.005379379,0.00002344238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973087,0.001270137,0.0007605132,0.00009639899,0.00001772994,0.00001318168,0.0001773583,0.00003241457,0.000323514],"genre_scores_gemma":[0.9980088,0.0003750736,0.0003748966,0.00006229336,0.000008609876,0.00001205525,0.0002476187,0.000005838042,0.0009049573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706066,"threshold_uncertainty_score":0.005707324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009381398506493147,"score_gpt":0.2268838159356108,"score_spread":0.2175024174291177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}