{"id":"W1150195032","doi":"10.1007/s00198-015-3284-x","title":"In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss","year":2015,"lang":"en","type":"article","venue":"Osteoporosis International","topic":"Bone health and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Simon Fraser University; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ovariectomized rat; Medicine; Reversing; In vivo; Conjugate; Osteoporosis; Internal medicine; Pharmacology; Rheumatology; Antagonist; Endocrinology; Estrogen; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129143,0.0004326466,0.0005015729,0.0004516532,0.0002109313,0.0001784911,0.0003802463,0.0005922974,0.00221293],"category_scores_gemma":[0.0001452984,0.0002284561,0.0003811316,0.0002136845,0.0003915407,0.0003774599,0.0001362447,0.0009502971,0.0002447279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001864319,"about_ca_system_score_gemma":0.000358365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007537309,"about_ca_topic_score_gemma":0.001391292,"domain_scores_codex":[0.9998962,0.000017105,0.000007917763,0.00001923185,0.0000245739,0.00003501236],"domain_scores_gemma":[0.9999174,0.00001528412,0.00001657848,0.000007719877,0.00001014709,0.0000329304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0108761,0.002125212,0.0002115771,0.0002351732,0.00005193783,0.0001775707,0.00003855508,0.0003587246,0.9741549,0.0002841254,0.000192509,0.01129355],"study_design_scores_gemma":[0.001257206,0.0228288,0.001805969,0.00001437898,0.0001977894,0.0002176768,0.00005583845,0.001308089,0.9692453,0.0001286338,0.002916511,0.00002382406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940395,0.002301109,0.001951735,0.0001519188,0.0001219903,0.0001093869,0.000237644,0.00006150155,0.001025274],"genre_scores_gemma":[0.988614,0.00248101,0.003379516,0.0001028049,0.00004969195,0.0001370174,0.0003262365,0.00001398345,0.004895634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221293,"threshold_uncertainty_score":0.007403016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0268512087336374,"score_gpt":0.3253135440502036,"score_spread":0.2984623353165662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}