{"id":"W1151070630","doi":"","title":"Can RB1 Mutation Analysis be Used to Predict Disease Expression in Patients With Heritable Retinoblastoma","year":2005,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Retinoblastoma; Genetics; Mutation; Biology; Expression (computer science); Mutation testing; Disease; Computational biology; Medicine; Internal medicine; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003287902,0.00020066,0.0003519979,0.0005186399,0.0002194661,0.00002128723,0.0001632208,0.00008641521,0.0001129705],"category_scores_gemma":[0.0004283566,0.000153939,0.0000495409,0.002384793,0.001319978,0.0003030241,0.00009029425,0.0001667072,0.00002308858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656191,"about_ca_system_score_gemma":0.0004789533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001083243,"about_ca_topic_score_gemma":0.00009516095,"domain_scores_codex":[0.9979047,0.0001625254,0.0002541388,0.0006749809,0.0005501613,0.0004534722],"domain_scores_gemma":[0.9986699,0.0000719454,0.0001201582,0.0002633645,0.0002131214,0.0006615557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004665353,0.0006706399,0.9862583,0.000006337584,0.00007048725,0.0003595958,0.000982136,0.0004838118,0.01058818,0.00000710247,0.00001208872,0.00009483691],"study_design_scores_gemma":[0.001822258,0.002064181,0.9644783,0.00007064293,0.0002231757,0.0000139649,0.00009434307,0.0006760382,0.03030901,0.00009442896,0.00001060981,0.0001430818],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972516,0.00001222959,0.000005494198,0.001759115,0.00003984205,0.0006549953,0.00002513561,0.000028852,0.0002227027],"genre_scores_gemma":[0.9961667,1.869978e-7,0.002975654,0.0004949154,0.0000227718,0.00008996609,0.00006977166,0.00001176532,0.0001682694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02177998,"threshold_uncertainty_score":0.6277452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298974849632091,"score_gpt":0.3275965950091287,"score_spread":0.3046068465128078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}