{"id":"W1151131272","doi":"10.1042/bcj20160200","title":"Engineered Cx26 variants established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Docking (animal); Homology modeling; Connexin; Macromolecular docking; Mutant; Chemistry; Cell biology; Biology; Protein structure; Biophysics; Gap junction; Biochemistry; Gene; Intracellular; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002532529,0.0004239242,0.0002599464,0.0001572109,0.0001938969,0.0002054294,0.000225135,0.000307531,0.002415155],"category_scores_gemma":[0.0001912405,0.0001362916,0.0002814337,0.0001556412,0.0002297451,0.0002189937,0.0002531933,0.0006977282,0.0005552666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714417,"about_ca_system_score_gemma":0.0001302431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997169,"about_ca_topic_score_gemma":0.0005073163,"domain_scores_codex":[0.9997726,0.00003386626,0.00003354549,0.00004976741,0.00005531144,0.00005496585],"domain_scores_gemma":[0.9998145,0.00001698163,0.00004779617,0.00002914366,0.00002559745,0.00006608362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008038813,0.00004575021,0.00008864311,0.0000309655,0.000006549438,0.0001143712,0.00001646587,0.0001325446,0.9984127,0.0003626099,0.00008061953,0.0006284853],"study_design_scores_gemma":[0.00004057533,0.0005337454,0.003135882,0.00001080394,0.00003265575,0.0006163316,0.00004431899,0.002582844,0.9853373,0.0001295419,0.007522945,0.00001306566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918854,0.000532802,0.005028663,0.00006280885,0.0001129558,0.00007344962,0.0005135773,0.00009927653,0.001691078],"genre_scores_gemma":[0.9897713,0.0005815283,0.004778474,0.00004422842,0.00002157129,0.0000642807,0.0008952742,0.00008841808,0.003754749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415155,"threshold_uncertainty_score":0.008079469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144268903758093,"score_gpt":0.2171529162912115,"score_spread":0.2027260259154022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}