{"id":"W1155846412","doi":"10.1016/j.jtbi.2015.07.032","title":"Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes","year":2015,"lang":"en","type":"article","venue":"Journal of Theoretical Biology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Avidity; Effector; Immunology; Autoimmunity; CD8; Cytotoxic T cell; T cell; Biology; Medicine; Immune system; Antigen; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009790396,0.0005113003,0.001102645,0.0008140962,0.0005964158,0.001272221,0.003520967,0.002119814,0.006652523],"category_scores_gemma":[0.001717116,0.0004103299,0.0009286374,0.0003935495,0.00145344,0.003191444,0.001234183,0.002164713,0.0008724457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001193271,"about_ca_system_score_gemma":0.0006402926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001727217,"about_ca_topic_score_gemma":0.0007554934,"domain_scores_codex":[0.999588,0.0001332763,0.00001154796,0.00005704884,0.0001106803,0.00009943717],"domain_scores_gemma":[0.9990211,0.000514584,0.00008010992,0.00006726819,0.0001124415,0.0002045542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001569326,0.0002055984,0.001276708,0.00008593532,0.0000330185,0.0004480069,0.0002236172,0.1515876,0.01052276,0.8273973,0.001537882,0.006524678],"study_design_scores_gemma":[0.00005305095,0.00006469832,0.0004042943,0.00001018308,0.00001397915,0.0001517186,0.00005170483,0.6244239,0.0003724584,0.3737823,0.0006534463,0.0000181752],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3805483,0.002266948,0.5458795,0.008668375,0.0007051231,0.00008831729,0.0002314871,0.0005898186,0.06102213],"genre_scores_gemma":[0.9699896,0.0005207935,0.01509725,0.0007638971,0.000295146,0.00008616986,0.00004146906,0.00006724677,0.01313843],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006652523,"threshold_uncertainty_score":0.02225494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146686538449797,"score_gpt":0.2548643717147731,"score_spread":0.2333975063302751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}