{"id":"W1166909979","doi":"10.1016/j.pupt.2015.08.006","title":"Roflumilast for asthma: Efficacy findings in mechanism of action studies","year":2015,"lang":"en","type":"article","venue":"Pulmonary Pharmacology & Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Roflumilast; Medicine; Bronchoconstriction; COPD; Asthma; Eosinophil; Sputum; Placebo; Immunology; Exhaled nitric oxide; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002610428,0.0001315946,0.0001739473,0.00007563012,0.00004538259,0.000003338256,0.00009303179,0.0001402542,0.000006131022],"category_scores_gemma":[0.00000945021,0.0001241352,0.0000674442,0.00009632102,0.00008904128,0.000007552258,0.000050849,0.00007472984,0.000002750193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004179591,"about_ca_system_score_gemma":0.00006050049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002399572,"about_ca_topic_score_gemma":0.000007502413,"domain_scores_codex":[0.999208,0.0000769019,0.0002277953,0.0002225471,0.00008117058,0.0001835986],"domain_scores_gemma":[0.999566,0.00003838151,0.00008829685,0.0001028859,0.0001576187,0.00004686581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001147795,0.0002630297,0.0007644842,0.00002708393,0.0001616579,0.00000230249,0.0002455579,0.000361385,0.9880559,0.00005764904,0.0009222295,0.007990903],"study_design_scores_gemma":[0.002230549,0.0006013337,0.00171103,0.00001024362,0.0001075816,0.00002182068,0.0006692469,0.001428351,0.8925265,0.0005219723,0.1000004,0.0001709967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937175,0.002492132,0.001398856,0.0006136866,0.001279628,0.0003908708,0.00001223094,0.00001420948,0.00008086902],"genre_scores_gemma":[0.9971586,0.000884065,0.0002700488,0.0009519054,0.0002033897,0.00006495899,0.00006661761,0.00001899647,0.0003814462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09907814,"threshold_uncertainty_score":0.5062088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065099509864014,"score_gpt":0.38063211823256,"score_spread":0.2741221672461586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}