{"id":"W1171856860","doi":"10.1016/j.actbio.2015.06.017","title":"Rational design of block copolymer micelles to control burst drug release at a nanoscale dimension","year":2015,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Ministry of Advanced Education, Government of Alberta; Royal Alexandra Hospital Foundation","keywords":"Micelle; Copolymer; Materials science; Caprolactone; Chemical engineering; Ethylene oxide; Polymer chemistry; Drug carrier; Drug delivery; Chemistry; Polymer; Organic chemistry; Nanotechnology; Aqueous solution; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006490201,0.0002311332,0.0003498511,0.0001069329,0.0001151013,0.00008133575,0.0003035924,0.00008449182,0.0005446645],"category_scores_gemma":[0.0001429554,0.0002031246,0.00005328107,0.000188929,0.0001523365,0.0002106623,0.0001677928,0.00002139707,0.001184225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362905,"about_ca_system_score_gemma":0.000167083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004419965,"about_ca_topic_score_gemma":0.0000189669,"domain_scores_codex":[0.9978141,0.0003427762,0.0005205708,0.0004199201,0.0005056619,0.0003969418],"domain_scores_gemma":[0.9986451,0.0001187859,0.0002163365,0.0004519032,0.0002221682,0.0003457533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001668437,0.000151638,0.0001123811,0.00001551085,0.00001178146,0.00001454367,0.0003522632,0.0001700712,0.9465138,0.00002995131,0.05095143,0.000008142404],"study_design_scores_gemma":[0.001982694,0.0001983534,0.0001037684,0.00004097752,0.00004653102,0.00001198143,0.00005169182,0.0003586711,0.9951176,0.00004083034,0.001800851,0.0002460621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956402,0.0001001251,0.0002115677,0.001054308,0.002075673,0.000544597,0.0002421377,0.0001057785,0.00002558688],"genre_scores_gemma":[0.9970493,0.000001801823,0.001768072,0.0003571612,0.0001565777,0.00004749915,0.00002563138,0.00003182855,0.000562116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04915058,"threshold_uncertainty_score":0.9995935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872593839676871,"score_gpt":0.2363028022626366,"score_spread":0.2175768638658679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}