{"id":"W1177541263","doi":"10.1089/ten.tea.2015.0153","title":"Activation of Transcription Factor <i>GAX</i> and Concomitant Downregulation of IL-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds","year":2015,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Cell biology; Calponin; Downregulation and upregulation; Vascular smooth muscle; Extracellular matrix; Phenotypic switching; Transcription factor; Phenotype; Biology; Proinflammatory cytokine; Actin; Immunology; Inflammation; Endocrinology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008419596,0.000235132,0.0001179461,0.00009777179,0.00009773516,0.0002035991,0.00008471211,0.0001689636,0.0005694436],"category_scores_gemma":[0.0000606772,0.00009778691,0.0002075927,0.00007192972,0.0002002902,0.000128388,0.0001003924,0.0002779178,0.0001372114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001381041,"about_ca_system_score_gemma":0.0001002835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002779403,"about_ca_topic_score_gemma":0.000566048,"domain_scores_codex":[0.9999179,0.00001026471,0.000006392333,0.00001793603,0.00002272629,0.00002475333],"domain_scores_gemma":[0.9999548,0.000007225239,0.00002041911,0.000003905031,0.000004000475,0.000009667157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002010246,0.000005741442,0.00004828045,0.00001035034,0.000001025744,0.00001064013,0.000004659585,0.00002584636,0.9996382,0.00002294178,0.000008874424,0.0002032503],"study_design_scores_gemma":[0.00001051741,0.0001125815,0.005105269,0.000003265423,0.000007261397,0.0001008831,0.00002146335,0.000908698,0.9927242,0.00004555454,0.0009568213,0.000003473546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949229,0.000685444,0.003000834,0.00005992063,0.00002842911,0.00001284141,0.000131834,0.00007628381,0.001081439],"genre_scores_gemma":[0.9960912,0.0005339804,0.001960372,0.00007026257,0.00001245188,0.0000441941,0.0001830846,0.00001498241,0.001089517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005694436,"threshold_uncertainty_score":0.001904964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265125120398674,"score_gpt":0.2171127673918451,"score_spread":0.2044615161878583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}