{"id":"W1180441934","doi":"10.1016/j.bmc.2015.08.023","title":"Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Acadia University","funders":"Natural Sciences and Engineering Research Council of Canada; Nova Scotia Health Research Foundation","keywords":"Chemistry; Cytotoxicity; Curcumin; Stereochemistry; Topoisomerase; Aryl; In vitro; In vivo; Chemical synthesis; Structure–activity relationship; Molecular model; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004360536,0.0005002226,0.0005414124,0.00006694392,0.0001317285,0.00001869149,0.0005317615,0.0004741319,0.0001268529],"category_scores_gemma":[0.0001670725,0.0004842203,0.0002314907,0.0003684619,0.0003179811,0.00001427671,0.0003004638,0.0002824834,0.000006851571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118228,"about_ca_system_score_gemma":0.0006782697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001512866,"about_ca_topic_score_gemma":0.00002743431,"domain_scores_codex":[0.9973392,0.00002427534,0.0006970898,0.0007847468,0.0005875283,0.0005671991],"domain_scores_gemma":[0.9979787,0.00001666217,0.0003581471,0.0008348554,0.0002591119,0.0005524867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558926,0.0003930199,0.0002122053,0.0001165456,0.000186136,0.00002076029,0.0002273226,0.000003466587,0.9965674,0.00005161218,0.0006020736,0.001263577],"study_design_scores_gemma":[0.003155254,0.0005511865,0.0001583991,0.0001044114,0.0001444489,0.0001575212,0.000695777,0.0000285611,0.9570029,0.0000364572,0.03745139,0.0005136973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893249,0.006703245,0.001940838,0.000291291,0.000610469,0.0003068734,0.0001102116,0.0000585332,0.0006536018],"genre_scores_gemma":[0.996392,0.0003671825,0.0005719267,0.0004000347,0.001148696,0.00004597643,0.0003981962,0.00008392327,0.0005920951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03956449,"threshold_uncertainty_score":0.9997609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280351997672472,"score_gpt":0.252126489878886,"score_spread":0.2293229699021613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}