{"id":"W1180441934","doi":"10.1016/j.bmc.2015.08.023","title":"Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Acadia University","funders":"Natural Sciences and Engineering Research Council of Canada; Nova Scotia Health Research Foundation","keywords":"Chemistry; Cytotoxicity; Curcumin; Stereochemistry; Topoisomerase; Aryl; In vitro; In vivo; Chemical synthesis; Structure–activity relationship; Molecular model; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008903872,0.0005360321,0.0002922367,0.0002085221,0.0001623578,0.0002213106,0.0002909595,0.000199461,0.001674533],"category_scores_gemma":[0.00006458192,0.0001756099,0.0001831454,0.0001136381,0.0001702824,0.0002688456,0.0001847289,0.0005881565,0.0007409207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162912,"about_ca_system_score_gemma":0.000220945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208123,"about_ca_topic_score_gemma":0.001410066,"domain_scores_codex":[0.9999608,0.000006694349,0.000001941386,0.00001019613,0.000006678109,0.0000136957],"domain_scores_gemma":[0.9999712,0.000003021996,0.000009046239,0.000003012523,0.000003924173,0.000009808986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005095972,0.0001263967,0.0001207335,0.0002665817,0.00001768019,0.000229571,0.00005048722,0.0004828648,0.9760946,0.0007844841,0.0009264508,0.02039056],"study_design_scores_gemma":[0.0002088083,0.001384031,0.00235139,0.0000273575,0.00005646458,0.0007716369,0.00004633284,0.001083303,0.9610301,0.0002239091,0.03279236,0.00002420687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8976066,0.04609163,0.02341435,0.001073991,0.0004889262,0.0003227972,0.001447825,0.001606471,0.02794743],"genre_scores_gemma":[0.9663454,0.01465284,0.00592601,0.0001911531,0.00007137543,0.0001085276,0.0005744052,0.00004810556,0.01208198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674533,"threshold_uncertainty_score":0.005601883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280351997672472,"score_gpt":0.252126489878886,"score_spread":0.2293229699021613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}