{"id":"W1181255371","doi":"10.1088/0953-8984/27/35/354103","title":"Consistent rationalization of type-2 topoisomerases' unknotting, decatenating, supercoil-relaxing actions and their scaling relation","year":2015,"lang":"en","type":"article","venue":"Journal of Physics Condensed Matter","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Topoisomerase; DNA supercoil; Knot (papermaking); DNA; Scaling; Curvature; Catenation; Biology; Physics; Genetics; Mathematics; Geometry; DNA replication; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780248,0.00007459409,0.0001178569,0.00003245303,0.00003224018,0.00001827735,0.00004356996,0.00005223756,0.00001256396],"category_scores_gemma":[0.00002763367,0.00006358285,0.00005448524,0.00005274142,0.00003176632,0.00001418563,0.00002174564,0.00006715441,0.00000182676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001899392,"about_ca_system_score_gemma":0.0001008996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004203526,"about_ca_topic_score_gemma":0.000003046499,"domain_scores_codex":[0.9994643,0.00003636152,0.0002457988,0.00008109055,0.0001031718,0.00006925982],"domain_scores_gemma":[0.9991384,0.00001629969,0.0002589149,0.00008168229,0.0004563464,0.00004834577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005839405,0.00003483006,0.002095766,0.00001367109,0.00008870666,3.933749e-7,0.0003991887,0.0007728661,0.9938546,0.0009977025,0.0006262574,0.001057624],"study_design_scores_gemma":[0.001290955,0.0003086367,0.0008162583,0.00007836917,0.00007658991,0.0000769559,0.0007285106,0.0007745661,0.9853602,0.005280422,0.005048918,0.0001596131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710075,0.0004022387,0.02778591,0.0002261649,0.0002416368,0.00005461041,0.000004185154,0.000001803546,0.0002759596],"genre_scores_gemma":[0.9984584,0.00004742711,0.0008004049,0.0003451592,0.0001932614,6.126613e-7,0.00001826034,0.00001228854,0.0001241902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02745091,"threshold_uncertainty_score":0.2592833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969240055775087,"score_gpt":0.2754651360580537,"score_spread":0.2357727355003028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}