{"id":"W1184641475","doi":"","title":"Targeted siRNA-Mediated Knockdown of p53 Family Activators ASPP1 and ASPP2 Delays Adult Retinal Ganglion Cell Death in vivo","year":2010,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Gene knockdown; In vivo; Retinal ganglion cell; Cell biology; Programmed cell death; Chemistry; Retinal; Biology; Apoptosis; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067018,0.0004650191,0.000405591,0.0003584042,0.0002449459,0.0004219345,0.0002909545,0.0004176956,0.001889926],"category_scores_gemma":[0.0001253424,0.0002402327,0.0003370792,0.0001698773,0.0003806255,0.0004267561,0.0001875383,0.001138379,0.0004885335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000579657,"about_ca_system_score_gemma":0.0005242022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011397,"about_ca_topic_score_gemma":0.002230393,"domain_scores_codex":[0.9998431,0.00001342679,0.00001568955,0.00004031018,0.00004321926,0.00004416614],"domain_scores_gemma":[0.9998271,0.00004164132,0.00004289855,0.00001851412,0.0000144216,0.00005547706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536312,0.00002507668,0.0000550459,0.00002586742,0.000006877186,0.00004236578,0.0000124913,0.00003950913,0.9986052,0.0001377381,0.00008789928,0.0008082659],"study_design_scores_gemma":[0.00002235721,0.0001840075,0.001180931,0.00000330218,0.00001497878,0.00009852018,0.00002189913,0.0005882903,0.9969303,0.00004804765,0.0009046145,0.000002786983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852507,0.002562623,0.007568774,0.000314244,0.00017314,0.00004896825,0.0008994953,0.0003774194,0.002804602],"genre_scores_gemma":[0.9855164,0.001496672,0.004719652,0.0001410416,0.00002309247,0.00007781293,0.0007376263,0.00007812865,0.007209575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889926,"threshold_uncertainty_score":0.006322384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846559087221514,"score_gpt":0.2930760485261971,"score_spread":0.274610457653982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}