{"id":"W1186303165","doi":"10.1089/ars.2013.5575","title":"Cells with Impaired Mitochondrial H <sub>2</sub> O <sub>2</sub> Sensing Generate Less <sup>•</sup> OH Radicals and Live Longer","year":2014,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"SOD2; Mitochondrial ROS; Aconitase; Oxidative stress; Reactive oxygen species; Mitochondrion; Superoxide dismutase; Glutathione; Catalase; Cell biology; Proteostasis; Biochemistry; Oxidative phosphorylation; Biology; Antioxidant; SOD1; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245342,0.000651437,0.0003539365,0.0001566795,0.0001337911,0.0003897235,0.0003042325,0.0003260921,0.001145293],"category_scores_gemma":[0.0001240982,0.0001314561,0.0002706853,0.0001937764,0.0003220592,0.0003041374,0.0002848002,0.0004184642,0.0004406905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809766,"about_ca_system_score_gemma":0.000175698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008766029,"about_ca_topic_score_gemma":0.0007827679,"domain_scores_codex":[0.9999073,0.000004588168,0.00001729899,0.00003250681,0.0000224864,0.00001587515],"domain_scores_gemma":[0.9996967,0.00002596053,0.0001239586,0.00004341363,0.00003631062,0.00007368637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001201387,0.00002514841,0.000984095,0.00003730732,0.000009956206,0.00006391658,0.00001313878,0.00005443502,0.9978305,0.00004910413,0.0000296934,0.0007826542],"study_design_scores_gemma":[0.00001155005,0.0001835313,0.01237785,0.000005017721,0.00002940712,0.0003921645,0.0000595557,0.0004742562,0.9854763,0.0000515391,0.0009316248,0.000007331091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950713,0.0004081787,0.003041826,0.00003724903,0.00002250125,0.00002398716,0.0009541142,0.0000972278,0.0003436145],"genre_scores_gemma":[0.9928108,0.0003706048,0.003454923,0.00005286754,0.000009132624,0.00004428477,0.001843821,0.00005481827,0.001358764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145293,"threshold_uncertainty_score":0.003831446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007096184745707921,"score_gpt":0.1956373289079074,"score_spread":0.1885411441621994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}