{"id":"W119113515","doi":"10.4049/jimmunol.182.supp.35.3","title":"Calculations show that T cell antigen discrimination requires multiple localized binding events (35.3)","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"T-cell receptor; Immunological synapse; Antigen; T cell; Peptide; Immune system; Major histocompatibility complex; Acquired immune system; Cell biology; Receptor; Cell; Biology; Biophysics; Computational biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005321071,0.0005486816,0.0004831324,0.0004040356,0.0004843008,0.0006215362,0.0009415402,0.0009182657,0.01899954],"category_scores_gemma":[0.00228876,0.0003425226,0.000620744,0.0002805293,0.0005431895,0.001504068,0.0003365539,0.0008413979,0.004530935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101912,"about_ca_system_score_gemma":0.0005211865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002353572,"about_ca_topic_score_gemma":0.0015591,"domain_scores_codex":[0.9996443,0.00005398222,0.00001456519,0.00007558731,0.0001420634,0.00006958032],"domain_scores_gemma":[0.9993623,0.0003258974,0.00008604061,0.00006928534,0.0001043513,0.0000521145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002586256,0.0002648087,0.006013185,0.0004198926,0.00009516613,0.0005868046,0.0001760391,0.56773,0.0490742,0.3106018,0.008552342,0.05622712],"study_design_scores_gemma":[0.00003277075,0.00006125046,0.002023445,0.00002240834,0.00002584932,0.0003491142,0.00003027255,0.9464997,0.006742237,0.04049091,0.003692028,0.00002994666],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2552079,0.001302397,0.684802,0.001862252,0.0004936247,0.0001540697,0.0004544354,0.0009065699,0.05481673],"genre_scores_gemma":[0.938765,0.0007157443,0.04426637,0.0003980878,0.00008973899,0.0002277391,0.0002788818,0.0002792187,0.01497921],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01899954,"threshold_uncertainty_score":0.06355983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458739155742116,"score_gpt":0.2558155789391798,"score_spread":0.2312281873817586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}