{"id":"W1191344064","doi":"10.1016/j.mce.2015.08.018","title":"Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line","year":2015,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Jarislowsky Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Massachusetts General Hospital","keywords":"MEG3; Pituitary tumors; Gene silencing; Cancer research; Biology; Epigenetics; Cell culture; Suppressor; Tumor suppressor gene; Gene expression; Gene; RNA; Long non-coding RNA; Carcinogenesis; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758448,0.0002528476,0.0003489414,0.0003127908,0.000337196,0.0003529827,0.000185617,0.0002344948,0.001924465],"category_scores_gemma":[0.0001802559,0.0001164782,0.0004279993,0.0004356694,0.0002350489,0.0001672072,0.0001918596,0.0007420824,0.0006553237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509816,"about_ca_system_score_gemma":0.0004531639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006202377,"about_ca_topic_score_gemma":0.005883324,"domain_scores_codex":[0.9998258,0.00002013855,0.000024721,0.00003679935,0.00004988448,0.0000426589],"domain_scores_gemma":[0.9998566,0.00004733869,0.00001486968,0.00002929629,0.00002825517,0.00002361659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001803291,0.0000455204,0.0004413968,0.00002503668,0.000007341353,0.0001659816,0.00006149138,0.00008770923,0.9975804,0.0001321796,0.0002028141,0.001069795],"study_design_scores_gemma":[0.00004087074,0.0004856255,0.006347146,0.00000395386,0.00004448263,0.0005189943,0.0001663789,0.001792942,0.9838514,0.00008122677,0.006655531,0.00001162991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888214,0.0008872773,0.003266876,0.0003120083,0.0001157258,0.00005037061,0.00374837,0.0001802905,0.002617697],"genre_scores_gemma":[0.9864503,0.0006144733,0.00274397,0.0001241337,0.00002468933,0.00006711536,0.00463802,0.00004653949,0.005290958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006202377,"threshold_uncertainty_score":0.01233256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105300307993731,"score_gpt":0.2556951566119358,"score_spread":0.2446421535319985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}