{"id":"W1192555119","doi":"10.1371/journal.ppat.1005102","title":"HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Ubiquitin ligase; IκB kinase; Jurkat cells; Phosphorylation; Ubiquitin; Kinase; Cell biology; Biology; Ubiquitin-conjugating enzyme; Molecular biology; Biochemistry; Signal transduction; NF-κB; T cell; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000691639,0.0002399992,0.0001075429,0.0001237251,0.00008259564,0.0001415546,0.00006849664,0.0001041739,0.0007960169],"category_scores_gemma":[0.00005495883,0.00007654462,0.000195838,0.0000962867,0.00007731343,0.00009106166,0.0001050701,0.0002226408,0.0002731294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407083,"about_ca_system_score_gemma":0.00009076457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004486467,"about_ca_topic_score_gemma":0.0008462375,"domain_scores_codex":[0.9999404,0.00001043707,0.000004287373,0.00001255145,0.00001148349,0.00002088124],"domain_scores_gemma":[0.9999762,0.000003991448,0.000006504694,0.000003359031,0.000002346565,0.00000752801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006609966,0.00001643246,0.0002485831,0.00001615482,0.000002643961,0.00002989976,0.000006562891,0.00002591474,0.9989551,0.00003354975,0.00003607432,0.0005630032],"study_design_scores_gemma":[0.00001288591,0.0001358393,0.006381711,0.000004334661,0.00001005754,0.0002564059,0.00002056137,0.0008376538,0.989948,0.0000352753,0.002355327,0.00000193361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965906,0.001110373,0.001000291,0.00004518021,0.00002131774,0.00001524361,0.0002753598,0.00003208125,0.0009094969],"genre_scores_gemma":[0.9949692,0.0005924515,0.001087055,0.00003413744,0.000007710262,0.00001879334,0.0007169552,0.000007322402,0.002566407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007960169,"threshold_uncertainty_score":0.002662957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04717510709184453,"score_gpt":0.2621183921682215,"score_spread":0.214943285076377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}