{"id":"W1193047888","doi":"10.1074/jbc.m115.644450","title":"β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Free fatty acid receptor 1; Arrestin; Heterotrimeric G protein; Signal transduction; G protein-coupled receptor; Cell biology; Agonist; G protein; Receptor; Functional selectivity; Biology; Internal medicine; Endocrinology; Chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000545991,0.0001773232,0.0002580817,0.00001418625,0.00005959894,0.00002526148,0.0002784267,0.0003136317,0.0002305674],"category_scores_gemma":[0.0006318205,0.0001229984,0.0001309222,0.00004444349,0.00009925935,0.000004234905,0.0002420886,0.0001827492,0.000005074234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000500155,"about_ca_system_score_gemma":0.00007279483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001475325,"about_ca_topic_score_gemma":4.374791e-7,"domain_scores_codex":[0.9989081,0.00006289084,0.0003820719,0.0002413943,0.0001845784,0.0002209548],"domain_scores_gemma":[0.9989647,0.000022821,0.0002929466,0.0002186854,0.000160815,0.0003400003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002805542,0.00005224946,0.001168513,0.000009656871,0.00003911562,0.00001468683,0.00002173018,0.000006803432,0.9921717,0.000003303658,0.005024892,0.001206796],"study_design_scores_gemma":[0.0010138,0.0005499505,0.0001829122,0.00002458001,0.00001277996,0.000184503,0.0001046181,0.00000572381,0.9583342,0.000263387,0.03916075,0.0001627887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953645,0.0029221,0.0006427659,0.0002711376,0.000220072,0.00008457284,0.00002049297,0.000007308076,0.0004670532],"genre_scores_gemma":[0.9919658,0.0005525791,0.006170365,0.0002007937,0.0007621462,0.00000785203,0.00004719281,0.00001357929,0.000279697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03413586,"threshold_uncertainty_score":0.5015729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08604263087196068,"score_gpt":0.2849544201652511,"score_spread":0.1989117892932904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}