{"id":"W1198940312","doi":"10.1182/blood.v124.21.3703.3703","title":"Initial Results from a Phase 2 Study of Blinatumomab in Pediatric Patients with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Blinatumomab; Medicine; Internal medicine; Refractory (planetary science); Minimal residual disease; Acute lymphocytic leukemia; Hematopoietic stem cell transplantation; Oncology; Salvage therapy; Phases of clinical research; Gastroenterology; Tumor lysis syndrome; Transplantation; Bone marrow; Leukemia; Chemotherapy; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002319023,0.001249198,0.001482744,0.0003022616,0.000386411,0.000720993,0.0005892768,0.000765102,0.002631191],"category_scores_gemma":[0.001163391,0.0004662879,0.000857622,0.0004409134,0.0005365515,0.0006273889,0.0003615789,0.00255096,0.0007764095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009919708,"about_ca_system_score_gemma":0.00168256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008829642,"about_ca_topic_score_gemma":0.002488541,"domain_scores_codex":[0.999311,0.0004027534,0.0000411451,0.0000761671,0.00006851532,0.0001005733],"domain_scores_gemma":[0.9992799,0.0001660449,0.0001410531,0.0000721195,0.00009137431,0.000249506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3589624,0.1348631,0.04682263,0.002446098,0.002833245,0.001587552,0.00153885,0.005286745,0.1547659,0.0007370323,0.01227611,0.2778803],"study_design_scores_gemma":[0.1877034,0.7266254,0.04625321,0.0001369228,0.00144362,0.001887979,0.0002595358,0.001325933,0.01856015,0.0002849808,0.01547338,0.00004546897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887469,0.003435415,0.001052079,0.0005592696,0.00006475411,0.002933176,0.001576132,0.00008578558,0.001546486],"genre_scores_gemma":[0.9803776,0.004869236,0.003977894,0.001008019,0.0001437996,0.003757071,0.004210049,0.00004764264,0.001608745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002631191,"threshold_uncertainty_score":0.01226431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009971044166260056,"score_gpt":0.2672487277404129,"score_spread":0.2572776835741528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}