{"id":"W1198940312","doi":"10.1182/blood.v124.21.3703.3703","title":"Initial Results from a Phase 2 Study of Blinatumomab in Pediatric Patients with Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Blinatumomab; Medicine; Internal medicine; Refractory (planetary science); Minimal residual disease; Acute lymphocytic leukemia; Hematopoietic stem cell transplantation; Oncology; Salvage therapy; Phases of clinical research; Gastroenterology; Tumor lysis syndrome; Transplantation; Bone marrow; Leukemia; Chemotherapy; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003810332,0.0003865091,0.000794568,0.0005882418,0.00006026066,0.00002286627,0.0003607302,0.0002368417,0.00003604801],"category_scores_gemma":[0.0009461003,0.0003083461,0.00007970057,0.0008607554,0.0001088652,0.0001743317,0.0001820301,0.000535516,0.00006911156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005597249,"about_ca_system_score_gemma":0.001438323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003894078,"about_ca_topic_score_gemma":0.00008291771,"domain_scores_codex":[0.9961088,0.0002747866,0.0009304304,0.0008047953,0.001277757,0.0006034031],"domain_scores_gemma":[0.9969962,0.001002018,0.0004204614,0.0008892866,0.000357976,0.0003340489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09785002,0.214118,0.6568772,0.0007837569,0.001612884,0.003065921,0.01290785,0.0001511964,0.003351977,0.00001217766,0.003129116,0.006139818],"study_design_scores_gemma":[0.6726449,0.04058826,0.2752949,0.0002849182,0.003081201,0.00002290449,0.0003718461,0.00149567,0.005403333,0.00003025038,0.0001440632,0.0006377235],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995991,0.00005383275,0.00005945264,0.0000176606,0.0001359748,0.00146954,0.0002790257,0.00006914583,0.001924385],"genre_scores_gemma":[0.9984829,0.00001689453,0.0004782134,0.00004711989,0.0003364281,0.00007603827,0.0003061972,0.00008450718,0.0001717453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5747949,"threshold_uncertainty_score":0.9999369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009971044166260056,"score_gpt":0.2672487277404129,"score_spread":0.2572776835741528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}