{"id":"W1201348515","doi":"10.1021/acs.inorgchem.5b01162","title":"Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1","year":2015,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"Division of Chemistry; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; Lilly Endowment","keywords":"Chemistry; Peptide; Copper; Binding site; Histidine; Peptide sequence; Active site; Cofactor; Redox; X-ray absorption spectroscopy; Stereochemistry; Amino acid; Crystallography; Biochemistry; Enzyme; Inorganic chemistry; Absorption spectroscopy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006270602,0.0002952885,0.0004568692,0.00003435864,0.0002609981,0.00001527661,0.0003555479,0.0001614667,0.0001081872],"category_scores_gemma":[0.0001840996,0.0002392345,0.0001096904,0.0001990471,0.0002653933,0.00009536617,0.0001303926,0.0004122526,0.00004070014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008876274,"about_ca_system_score_gemma":0.0001080469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006563772,"about_ca_topic_score_gemma":0.0001641615,"domain_scores_codex":[0.9978275,0.00005436211,0.0007103976,0.0004314449,0.0005131423,0.0004631569],"domain_scores_gemma":[0.9984717,0.0001347789,0.0003493778,0.000678269,0.0002009841,0.0001648887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234024,0.0001011651,0.009471465,0.0004680996,0.00008163314,0.00002243713,0.005894789,0.00007850973,0.930432,0.000002943297,0.05311108,0.0002124618],"study_design_scores_gemma":[0.002178235,0.0001239139,0.001401848,0.0003475647,0.0002637217,0.0001254945,0.001819248,0.0003155252,0.9913055,0.0001568337,0.00150644,0.0004556391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959018,0.001117323,0.00000907627,0.001316819,0.0003914963,0.0002403889,0.0001245895,0.00009841957,0.0008001267],"genre_scores_gemma":[0.9922863,0.00001727705,0.0004039773,0.0001823723,0.0002533523,0.00002109374,0.00008839982,0.00006385479,0.006683339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06087352,"threshold_uncertainty_score":0.9755698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0762430532007939,"score_gpt":0.3401030556755773,"score_spread":0.2638600024747834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}