{"id":"W1201348515","doi":"10.1021/acs.inorgchem.5b01162","title":"Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1","year":2015,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"Division of Chemistry; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; Lilly Endowment","keywords":"Chemistry; Peptide; Copper; Binding site; Histidine; Peptide sequence; Active site; Cofactor; Redox; X-ray absorption spectroscopy; Stereochemistry; Amino acid; Crystallography; Biochemistry; Enzyme; Inorganic chemistry; Absorption spectroscopy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008686227,0.0003834153,0.0001944181,0.00009380125,0.0002318714,0.000182764,0.0004588231,0.0006157192,0.002094281],"category_scores_gemma":[0.0002476231,0.0001517555,0.0002212033,0.0001181583,0.0001745735,0.0003340508,0.0001253916,0.0004494313,0.0003404441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528582,"about_ca_system_score_gemma":0.0001985757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410216,"about_ca_topic_score_gemma":0.0007400295,"domain_scores_codex":[0.9999312,0.00001098967,0.000002816778,0.00002455204,0.00001785928,0.00001247678],"domain_scores_gemma":[0.9999049,0.00002929994,0.0000276262,0.000004459727,0.00001513421,0.00001851217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007299132,0.00008470181,0.001438099,0.0001630414,0.00002594975,0.001142437,0.0001191829,0.00460428,0.9868048,0.001256647,0.0005911324,0.003039662],"study_design_scores_gemma":[0.0001309068,0.001367508,0.007171044,0.00003330003,0.00006571811,0.002575666,0.0001887979,0.04181384,0.9370648,0.0009687786,0.008573098,0.0000465172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904706,0.001023354,0.005827864,0.0002210731,0.00003152526,0.00002227699,0.0005222731,0.00007471844,0.001806246],"genre_scores_gemma":[0.9909826,0.0005163811,0.006000741,0.00009347833,0.000009806525,0.00001304381,0.00108197,0.00001584972,0.001286121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094281,"threshold_uncertainty_score":0.007006049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0762430532007939,"score_gpt":0.3401030556755773,"score_spread":0.2638600024747834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}