{"id":"W1221966150","doi":"10.1023/a:1011680529073","title":"Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers","year":2001,"lang":"en","type":"article","venue":"Chromosome Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"D-Wave Systems (Canada)","funders":"","keywords":"Transfection; Lipofectamine; Biology; Molecular biology; Reporter gene; Human artificial chromosome; Plasmid; Gene delivery; Genetic enhancement; Selectable marker; Gene; Cell biology; Chromosome; Vector (molecular biology); Genetics; Gene expression; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006974632,0.0005381,0.0003936375,0.0003200236,0.000306423,0.0005364339,0.000314623,0.0004413312,0.000850432],"category_scores_gemma":[0.0003078364,0.0002912873,0.0004616762,0.0002276251,0.000343095,0.0003655508,0.0005043184,0.0005687686,0.0004778391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005305255,"about_ca_system_score_gemma":0.0003485097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009092634,"about_ca_topic_score_gemma":0.001294829,"domain_scores_codex":[0.9997354,0.00005983781,0.00003312294,0.00004612263,0.00005245799,0.00007304564],"domain_scores_gemma":[0.999775,0.00007376124,0.00005595652,0.00004750898,0.00002111075,0.00002661639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004498702,0.000005262111,0.00003371243,0.00002052246,0.000002920756,0.00001897437,0.00002669473,0.00004091402,0.9992218,0.000173311,0.00001007495,0.0004007013],"study_design_scores_gemma":[0.000006470466,0.0000508665,0.0001809029,0.000001264243,0.000006686781,0.00002889689,0.000004769885,0.0000886735,0.9985885,0.00002304144,0.001018323,0.000001667204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689051,0.001593177,0.02511879,0.0001303371,0.00007808584,0.0001477336,0.0003154771,0.0002317573,0.003479627],"genre_scores_gemma":[0.9850162,0.0009361378,0.007006519,0.00003324963,0.00001440066,0.00007981682,0.000441542,0.00008711542,0.006384959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009092634,"threshold_uncertainty_score":0.003849268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377344554718433,"score_gpt":0.326431237770308,"score_spread":0.2826577922231236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}