{"id":"W1223459945","doi":"10.1038/mt.2015.135","title":"Hemophilia Gene Therapy: Caught Between a Cure and an Immune Response","year":2015,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic enhancement; Immune system; Immunology; Gene; Medicine; Biology; Virology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001570494,0.0007003938,0.001176149,0.0003709289,0.0001433493,0.00009531208,0.0003416584,0.001439328,0.0001103909],"category_scores_gemma":[0.000234985,0.0005167364,0.0002848684,0.0003240797,0.0002484246,0.00008502647,0.00009224099,0.001255551,0.00007564667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254825,"about_ca_system_score_gemma":0.001273688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009290154,"about_ca_topic_score_gemma":0.00000226764,"domain_scores_codex":[0.9954792,0.0007764876,0.000459859,0.0009142742,0.001694754,0.0006753888],"domain_scores_gemma":[0.9970086,0.0002985902,0.0001465196,0.00133083,0.0005690622,0.0006464412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02247135,0.0008316548,0.0004360549,0.0001073066,0.002412061,0.003443626,0.001278366,5.342546e-7,0.2353699,0.000007534891,0.6982477,0.03539393],"study_design_scores_gemma":[0.009409594,0.003227689,0.0005323488,0.0001152634,0.0001157292,0.00002391201,0.00002354916,0.00000381972,0.03559296,0.0002003386,0.9502581,0.0004966418],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.8151085,0.06648327,0.00002526169,0.00495472,0.1102811,0.002285435,0.0003364462,0.0002088228,0.0003164208],"genre_scores_gemma":[0.0263569,0.03793122,0.001091665,0.0004529789,0.897929,0.0002605885,0.006661648,0.0007601637,0.02855581],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.7887516,"threshold_uncertainty_score":0.999857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03282332153082979,"score_gpt":0.3553099728218681,"score_spread":0.3224866512910383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}