{"id":"W1223459945","doi":"10.1038/mt.2015.135","title":"Hemophilia Gene Therapy: Caught Between a Cure and an Immune Response","year":2015,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic enhancement; Immune system; Immunology; Gene; Medicine; Biology; Virology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004113108,0.0004884928,0.0009468917,0.0006593032,0.0008367467,0.003201027,0.0005107243,0.002834723,0.00490085],"category_scores_gemma":[0.00309509,0.0002621573,0.0004063801,0.000269418,0.003294141,0.004979623,0.001834548,0.006683209,0.001733337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001394285,"about_ca_system_score_gemma":0.0008691872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002574695,"about_ca_topic_score_gemma":0.0004828405,"domain_scores_codex":[0.9981965,0.0006785042,0.0001330397,0.0001766279,0.0006579272,0.0001573908],"domain_scores_gemma":[0.9984801,0.0007640065,0.0001478402,0.00009315008,0.0002651463,0.0002496558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008609559,0.0003682946,0.001643877,0.002280499,0.0001659964,0.001605925,0.001693762,0.0004192928,0.02695681,0.1679635,0.2810646,0.5149765],"study_design_scores_gemma":[0.0001778788,0.0009412965,0.001080018,0.001366076,0.00007020427,0.003356346,0.001021379,0.0004151221,0.005610426,0.0508417,0.9350539,0.0000657343],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.01727487,0.411888,0.009023615,0.52198,0.01611097,0.0000504154,0.00007289046,0.0003205652,0.02327865],"genre_scores_gemma":[0.2371852,0.3831616,0.01255244,0.3017918,0.02397207,0.0001929767,0.0002190169,0.0003251008,0.04059964],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.00490085,"threshold_uncertainty_score":0.02175248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03282332153082979,"score_gpt":0.3553099728218681,"score_spread":0.3224866512910383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}