{"id":"W122659811","doi":"10.1161/circ.118.suppl_18.s_339-c","title":"Abstract 1507: Disruption of KCNH2 Trafficking May Contribute to Severe Clinical Phenotype of Trafficking Deficient Long-QT Type-1 Mutation KCNQ1-T587M","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"","keywords":"Phenotype; Long QT syndrome; Mutation; Mutant; Transfection; hERG; Genetics; Cell biology; Wild type; Medicine; Biology; Gene; Internal medicine; QT interval; Potassium channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000302633,0.0001286263,0.0002279418,0.0000609408,0.00009942071,0.000005630391,0.00007804298,0.0002644599,0.0000103067],"category_scores_gemma":[0.0001890426,0.0001228707,0.0001310789,0.0001809724,0.00009392574,0.000007041785,0.00003002775,0.0001043433,0.00000946822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231432,"about_ca_system_score_gemma":0.00005835934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001073442,"about_ca_topic_score_gemma":0.00001546246,"domain_scores_codex":[0.9987838,0.00005737011,0.0005274593,0.0002804703,0.0001842674,0.0001666557],"domain_scores_gemma":[0.9991724,0.00003568544,0.000270093,0.0001856847,0.0002811813,0.0000549108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000773514,0.0008989956,0.3036554,0.0003242957,0.000577278,0.00002923969,0.002405745,0.1436145,0.4822963,0.0002931439,0.000776552,0.06435509],"study_design_scores_gemma":[0.0009195396,0.0002168923,0.9791753,0.00008891853,0.00006933391,0.00003557134,0.0001483998,0.0009966239,0.01778603,0.00001075617,0.0003408625,0.0002117427],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99417,0.0009995374,0.003785544,0.00006807232,0.0003638967,0.000255968,0.00001274107,0.00001711437,0.0003271523],"genre_scores_gemma":[0.9991482,0.000203937,0.0002367865,0.00003803038,0.0001352385,0.000002699601,0.0001963604,0.00001581207,0.00002290031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6755199,"threshold_uncertainty_score":0.5010523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122468794718511,"score_gpt":0.3096749391356345,"score_spread":0.2784502511884493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}