{"id":"W122659811","doi":"10.1161/circ.118.suppl_18.s_339-c","title":"Abstract 1507: Disruption of KCNH2 Trafficking May Contribute to Severe Clinical Phenotype of Trafficking Deficient Long-QT Type-1 Mutation KCNQ1-T587M","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"","keywords":"Phenotype; Long QT syndrome; Mutation; Mutant; Transfection; hERG; Genetics; Cell biology; Wild type; Medicine; Biology; Gene; Internal medicine; QT interval; Potassium channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348638,0.00046532,0.0004752537,0.0001542085,0.0001671018,0.0002272729,0.0003027519,0.0006031498,0.00790768],"category_scores_gemma":[0.0002251242,0.0001246498,0.0002857268,0.00007765731,0.0004534398,0.0001843655,0.0002424491,0.0007481613,0.001794865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528155,"about_ca_system_score_gemma":0.0001563716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00033726,"about_ca_topic_score_gemma":0.0002472784,"domain_scores_codex":[0.9998835,0.0000204614,0.00001648626,0.00003096856,0.00003059358,0.00001797021],"domain_scores_gemma":[0.9998803,0.00002729446,0.0000322951,0.000007557441,0.00001131127,0.00004120959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003917912,0.00007568891,0.0009585519,0.00009052861,0.00001516338,0.002191317,0.00003066551,0.00003708649,0.9948211,0.0001100706,0.0002501151,0.00102792],"study_design_scores_gemma":[0.0004587401,0.002351487,0.07256562,0.0001211669,0.0001820657,0.02893697,0.0002845558,0.003778,0.881545,0.0005816568,0.00916566,0.00002906167],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964259,0.0005974741,0.0008704849,0.0003696101,0.00008147992,0.0000362852,0.0003028842,0.00004737874,0.001268477],"genre_scores_gemma":[0.9956203,0.0002873278,0.0009649692,0.0001873703,0.00006940454,0.00004804629,0.0003277677,0.0000373948,0.002457474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00790768,"threshold_uncertainty_score":0.02645385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122468794718511,"score_gpt":0.3096749391356345,"score_spread":0.2784502511884493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}